The diagnostic capabilities of polarization-correlation analysis of scattered light in biological tissues to differentiate between benign and malignant tumors

Iryna Soltys; Alexander Olar; Natalia Pavlyukovich; Yelena Kurek; Alexander Salega; Yaroslav Struk; Oleg Vanchulyak; Igor Oliynyk; Iryna Drin

doi:10.1117/12.3014204

5 January 2024 The diagnostic capabilities of polarization-correlation analysis of scattered light in biological tissues to differentiate between benign and malignant tumors

Iryna Soltys, Alexander Olar, Natalia Pavlyukovich, Yelena Kurek, Alexander Salega, Yaroslav Struk, Oleg Vanchulyak, Igor Oliynyk, Iryna Drin

Author Affiliations +

Proceedings Volume 12938, Sixteenth International Conference on Correlation Optics; 129381L (2024) https://doi.org/10.1117/12.3014204
Event: International Conference Correlation Optics (COR 2023), 2023, Chernivtsi, Ukraine

Abstract

The provided materials present the results of the diagnostic application of polarization-correlation cartography of microscopic images of the polycrystalline component of biological tissues for the differential diagnosis of benign (adenoma) and malignant (adenocarcinoma) prostate tumors. For microscopic images of histological sections of adenoma and adenocarcinoma biopsies, integral and layered maps, as well as histograms of the distributions of the following parameters are provided: 1. The modulus of the fourth parameter |𝑆𝐾4 12| of the polarization-correlation vector. 2. The argument of the fourth parameter 𝐴𝑟𝑔(𝑆4 12) of the polarization-correlation vector. Systematized tables contain the values of central statistical moments of the 1st to 4th order, which characterize the polarization-correlation, wavelet, and multifractal parameters of the polarization-correlation maps |𝑆𝐾4 12|(𝑚 × 𝑛) and 𝐴𝑟𝑔(𝑆4 12) (𝑚 × 𝑛). Additionally, a set of the most sensitive diagnostic markers has been determined, representing statistical parameters that are highly responsive to changes in the polycrystalline structure of biological samples.

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Iryna Soltys, Alexander Olar, Natalia Pavlyukovich, Yelena Kurek, Alexander Salega, Yaroslav Struk, Oleg Vanchulyak, Igor Oliynyk, and Iryna Drin "The diagnostic capabilities of polarization-correlation analysis of scattered light in biological tissues to differentiate between benign and malignant tumors", Proc. SPIE 12938, Sixteenth International Conference on Correlation Optics, 129381L (5 January 2024); https://doi.org/10.1117/12.3014204

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