A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system

Hongjing Sun; Dennis Sourvanos; Mary Potasek; Gene Parilov; Carl Beesonk; Timothy C. Zhu

doi:10.1117/12.2650456

14 March 2023 A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system

Hongjing Sun, Dennis Sourvanos, Mary Potasek, Gene Parilov, Carl Beesonk, Timothy C. Zhu

Proceedings Volume 12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; 123590C (2023) https://doi.org/10.1117/12.2650456
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Photodynamic therapy (PDT) has been used intraoperatively to treat patients with malignant pleural mesothelioma. For the efficiency of PDT, it is crucial to deliver light doses uniformly. The current procedure utilizes eight light detectors placed inside the pleural cavity to monitor the light. An updated navigation system, combined with a novel scanning system, is developed to provide real-time guidance for physicians during pleural PDT to improve light delivery. The scanning system consists of two handheld three-dimensional (3D) scanners to capture the pleural cavity's surface topographies quickly and precisely before PDT so that the target surface can be identified for real-time light fluence distribution calculation during PDT. An algorithm is developed to further process the scanned volume to denoise for accurate light fluence calculation and rotate the local coordinate system into any desired direction for a clear visualization during the real-time guidance. The navigation coordinate system is registered to the patient coordinate system utilizing at least three markers to track the light source point position within the pleural cavity throughout the treatment. During PDT, the light source position, the scanned pleural cavity, and the light fluence distribution for the cavity's surface will be displayed in 3D and 2D, respectively. For validation, this novel system is tested using phantom studies with a large chest phantom and 3D-printed lung phantoms of different volumes based on a personal CT scan, immersed in a liquid tissue-simulating phantom with different optical properties, and treated with eight isotropic detectors and the navigation system.

Citation Download Citation

Hongjing Sun, Dennis Sourvanos, Mary Potasek, Gene Parilov, Carl Beesonk, and Timothy C. Zhu "A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system", Proc. SPIE 12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, 123590C (14 March 2023); https://doi.org/10.1117/12.2650456

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