Presentation + Paper
8 March 2023 Epidermal-dermal segmentation and polarization feature analysis using advanced Jones matrix optical coherence tomography
Author Affiliations +
Abstract
Jones matrix optical coherence tomography (JM-OCT) is a form of polarization-sensitive OCT (PS-OCT) that allows for the simultaneous and high-quality in vivo capture of multiple polarization-based imaging contrasts. Our system allows for the capture of high-sensitivity structural OCT, degree of polarization uniformity (DOPU), and birefringence images. Segmenting the epidermal-dermal junction is a topic of high interest in OCT and dermatology. While others have explored this with traditional OCT, no other groups have used this type of segmentation with JM-OCT. We believe that combining a reliable segmentation procedure with the robust and localized characterization provided by JM-OCT can help fully utilize the strengths of both techniques and allow for a better characterization of the skin layers. Here, we utilize JM-OCT to assess the skin properties of healthy volunteers. Using high-sensitivity OCT, we quantified the epidermal thickness of various locations in vivo and were able to segment the epidermis, dermis, and stratum corneum in thick skin. Polarization imaging is sensitive to specific structures in the skin, such as collagen and melanin, and we were able to quantify the depolarization, and birefringence caused by these structures in different skin layers. In thick skin, localized polarization results showed an average DOPU of 0.89 in the dermis compared to an average of 0.79 in the stratum corneum. However, in both thick and thin skin, DOPU was lower overall in the epidermis compared to the dermis, indicating that most observed depolarization occurs due to the structure of the stratum corneum. Birefringence was found to be higher in the dermis than the epidermis in both cases.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sina Maloufi, Xin Zhou, Daniel C. Louie, Mitra Mirsalehi, Tim K. Lee, and Shuo Tang "Epidermal-dermal segmentation and polarization feature analysis using advanced Jones matrix optical coherence tomography", Proc. SPIE 12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, 123670O (8 March 2023); https://doi.org/10.1117/12.2653006
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Skin

Optical coherence tomography

Birefringence

Polarization

Image segmentation

Depolarization

Matrices

Back to Top