Analysis of attenuation coefficient and polarization-based contrasts in skin using polarization-sensitive optical coherence tomography

Mitra Mirsalehi; Sina Maloufi; Xin Zhou; Daniel C. Louie; Tim K. Lee; Shuo Tang

doi:10.1117/12.3001991

12 March 2024 Analysis of attenuation coefficient and polarization-based contrasts in skin using polarization-sensitive optical coherence tomography

Mitra Mirsalehi, Sina Maloufi, Xin Zhou, Daniel C. Louie, Tim K. Lee, Shuo Tang

Author Affiliations +

Proceedings Volume 12816, Photonics in Dermatology and Plastic Surgery 2024; 128160D (2024) https://doi.org/10.1117/12.3001991
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Polarization-Sensitive Optical Coherence Tomography (PS-OCT) is a real-time 3D imaging technique providing structural and functional contrasts in tissue. Previously, we have quantified multiple contrasts such as back-scattered intensity, accumulated phase retardation, local birefringence, and degree of polarization uniformity in the epidermis and dermis of the skin. Here, we add the Attenuation Coefficient (AC) contrast to quantify light attenuation from absorption and scattering in skin layers. Two techniques are utilized to obtain AC. One involves slope fitting to the logarithm of intensity A-lines, and the other uses a depth-resolved model-based reconstruction of AC. To investigate the effect of skin tone on AC, we first used skin phantoms with various absorption and scattering coefficients. It is found that the color of the phantom directly correlates with the absorption coefficient, while AC correlates with the sum of the absorption and reduced scattering coefficient. Darker objects, indicative of a higher concentration of melanin in the skin tissue, show a higher absorption coefficient. AC is further analyzed on in vivo skin imaging with different skin tones. However, no clear correlation between AC and skin tone is observed. This lack of correlation is likely due to the absorption coefficient being much smaller than the scattering coefficient in skin tissue at the OCT imaging wavelength of 1060nm.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mitra Mirsalehi, Sina Maloufi, Xin Zhou, Daniel C. Louie, Tim K. Lee, and Shuo Tang "Analysis of attenuation coefficient and polarization-based contrasts in skin using polarization-sensitive optical coherence tomography", Proc. SPIE 12816, Photonics in Dermatology and Plastic Surgery 2024, 128160D (12 March 2024); https://doi.org/10.1117/12.3001991

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available