Glucose electrochemical biosensors: research progress and challenges

Mingmin Zhou

doi:10.1117/12.3012929

8 January 2024 Glucose electrochemical biosensors: research progress and challenges

Mingmin Zhou

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129241G (2024) https://doi.org/10.1117/12.3012929
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

One major health issue in the world is diabetes mellitus. Glucose monitoring is critical in diabetes management. Since Clark and Lyons’s proposal of glucose enzyme electrodes in 1962, glucose biosensor technology has advanced, enabling diabetic people to monitor and control their blood sugar levels, ultimately saving lives. Their great economic prospects and attract the increasing interest in sensor design and basic principles for glucose biosensing. One major focus has been on the amperometric glucose biosensors based on enzymes, especially glucose oxidase (GOx). Such biosensors are the most common to use but also have many disadvantages to encounter. Therefore, the other focus has been on realizing direct oxidation of glucose on the electrode surface by using nano fabricating technology. This paper reviews the history and basic mechanisms of electrochemical glucose biosensors, focusing on the different generations of enzyme-based and enzyme-free biosensors. Significant restrictions are also mentioned in this paper and needed to be solved to develop more reliable, sensitive, economical and selective glucose biosensors.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mingmin Zhou "Glucose electrochemical biosensors: research progress and challenges", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129241G (8 January 2024); https://doi.org/10.1117/12.3012929

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