Treatment parameters affecting the response of normal brain to photodynamic therapy

Qun Chen; Michael Chopp; Mary O. Dereski; Brian C. Wilson; Michael S. Patterson; David Kessel; Larry Heads; Fred W. Hetzel

doi:10.1117/12.146304

18 June 1993 Treatment parameters affecting the response of normal brain to photodynamic therapy

Qun Chen, Michael Chopp, Mary O. Dereski, Brian C. Wilson, Michael S. Patterson, David Kessel, Larry Heads, Fred W. Hetzel

Author Affiliations +

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146304
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Different aspects of photodynamic therapy in normal rat brain tissue have been studied, in an effort to understand and improve the dosimetry of this new modality in treatment of brain tumors. dosimetry parameters, including light energy dose, fluence rate and beam size, and drug dosage were studied. PDT induced lesion depth in brain was measured as a biological endpoint. Effective attenuation depth and absolute light fluence rate distribution under superficial irradiation were measured using invasive optical probes. Photosensitizer uptake was quantified using HPLC analysis. The results indicate that normal brain have a high intrinsic sensitivity to PDT treatment, based on the estimated photodynamic threshold.

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Qun Chen, Michael Chopp, Mary O. Dereski, Brian C. Wilson, Michael S. Patterson, David Kessel, Larry Heads, and Fred W. Hetzel "Treatment parameters affecting the response of normal brain to photodynamic therapy", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146304

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KEYWORDS

Brain

Photodynamic therapy

Tumors

Optical testing

Tissue optics

Tumor growth modeling

Biological research

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