Dr. Qun Chen Profile

Dr. Qun Chen

Chief/Biomedical Physics Research at South China Normal Univ

SPIE Involvement:

Author

Publications (46)

Proceedings Article | 17 September 2014 Paper

Multifunctional upconversion nanoprobe for tumor fluorescence imaging and near-infrared thermal therapy

Yanchun Wei, Qun Chen, Baoyan Wu, Da Xing

Proceedings Volume 9230, 923025 (2014) https://doi.org/10.1117/12.2069018

KEYWORDS: Tumors, Luminescence, Nanoprobes, Absorption, Near infrared, Upconversion, Laser therapeutics, Nanoparticles, Particles, Tissue optics

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SPIE Journal Paper | 1 March 2010 Open Access

Quantitative measurement of reactive oxygen species in vivo by utilizing a novel method: chemiluminescence with an internal fluorescence as reference

Yanchun Wei, Da Xing, Shiming Luo, Liyong Yang, Qun Chen

JBO, Vol. 15, Issue 02, 027006, (March 2010) https://doi.org/10.1117/12.10.1117/1.3368688

KEYWORDS: Photodynamic therapy, Oxygen, In vivo imaging, Luminescence, Chemiluminescence, Tissues, Skin, Photons, Tissue optics, Life sciences

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SPIE Journal Paper | 1 March 2008 Open Access

Monitoring singlet oxygen in situ with delayed chemiluminescence to deduce the effect of photodynamic therapy

Yanchun Wei, Xing Da, Shiming Luo, Wei Xu, Qun Chen

JBO, Vol. 13, Issue 02, 024023, (March 2008) https://doi.org/10.1117/12.10.1117/1.2904961

KEYWORDS: Photodynamic therapy, Skin, Oxygen, Luminescence, In vivo imaging, Chemiluminescence, Tissue optics, In situ metrology, Signal detection, Light scattering

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Proceedings Article | 25 February 2008 Paper

Preliminary study of transurethral photodynamic therapy mediated with Tookad in a canine prostate model

Zheng Huang, Fred Hetzel, Qun Chen, Kenneth Dole

Proceedings Volume 6845, 68450J (2008) https://doi.org/10.1117/12.760741

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Diffusers, Prostate cancer, Surgery, Tumor growth modeling, Visualization, Animal model studies, Bladder

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Proceedings Article | 1 May 2007 Paper

Using delayed chemiluminescence as a photodynamic therapy dose metric in vivo

Yanchun Wei, Da Xing, Qun Chen

Proceedings Volume 6534, 65342H (2007) https://doi.org/10.1117/12.741308

KEYWORDS: Photodynamic therapy, In vivo imaging, Chemiluminescence, Oxygen, Luminescence, Skin, Tumors, Statistical analysis, Photosensitizer targeting, Tissue optics

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Proceedings Article | 27 February 2007 Paper

Effect of implanted brachytherapy seeds on optical fluence distribution: preliminary ex vivo study

Fred Hetzel, Qun Chen, Meisong Ding, Francis Newman, Kenneth Dole, Zheng Huang, Dominique Blanc

Proceedings Volume 6427, 64270J (2007) https://doi.org/10.1117/12.700756

KEYWORDS: Photodynamic therapy, Prostate, Sensors, Prostate cancer, Tissue optics, Diffusers, Light sources, Radio optics, X-rays, Light scattering

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SPIE Journal Paper | 1 January 2007 Open Access

In vivo monitoring of singlet oxygen using delayed chemiluminescence during photodynamic therapy

Yanchun Wei, Jing Zhou, Da Xing, Qun Chen

JBO, Vol. 12, Issue 01, 014002, (January 2007) https://doi.org/10.1117/12.10.1117/1.2437151

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Proceedings Article | 27 October 2006 Paper

Enhancement mechanism of FCLA-1O2 chemiluminescence by human serum albumin

Jing Zhou, Da Xing, Qun Chen

Proceedings Volume 6047, 60473G (2006) https://doi.org/10.1117/12.710725

KEYWORDS: Proteins, Luminescence, Chemiluminescence, Oxygen, Absorption, Spectroscopy, Analog electronics, Energy transfer, Cancer, In vivo imaging

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Proceedings Article | 27 October 2006 Paper

Cell cycle dependence of protophorphyrin IX generation in 9L rat gliosarcoma

Shiming Luo, Xing Da, Qun Chen

Proceedings Volume 6047, 60473A (2006) https://doi.org/10.1117/12.710931

KEYWORDS: Photodynamic therapy, Cell death, Tumors, Brain, Tissue optics, Oxygen, Iron, Photosensitizer targeting, Tissues, Luminescence

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Proceedings Article | 27 October 2006 Paper

FRET analysis demonstrates a rapid activating of caspase-3 during PDT-induced apoptosis

Yunxia Wu, Qun Chen

Proceedings Volume 6047, 60473H (2006) https://doi.org/10.1117/12.710939

KEYWORDS: Cell death, Photodynamic therapy, Fluorescence resonance energy transfer, Tumors, Luminescence, Receptors, Confocal microscopy, Lung, Laser scanners, Pathogens

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Proceedings Article | 27 October 2006 Paper

Feasibility of chemiluminescence as photodynamic therapy dosimetor

Yanfang Qin, Da Xing, Xueyun Zhong, Jin Zhou, Shiming Luo, Qun Chen

Proceedings Volume 6047, 60473B (2006) https://doi.org/10.1117/12.710705

KEYWORDS: Photodynamic therapy, Oxygen, Chemiluminescence, Quenching (fluorescence), Laser therapeutics, Phototherapy, Photosensitizer targeting, Analog electronics, Lymphoma, Time metrology

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Proceedings Article | 6 March 2006 Paper

Mechanism of singlet oxygen chemiluminescence enhancement by human serum albumin

Jing Zhou, Da Xing, Qun Chen

Proceedings Volume 6139, 61390U (2006) https://doi.org/10.1117/12.643602

KEYWORDS: Luminescence, Oxygen, Proteins, Energy transfer, Chemiluminescence, Spectroscopy, Absorption, Photons, Analog electronics, Molecules

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Proceedings Article | 6 March 2006 Paper

Evaluation of Tookad-mediated photodynamic effect on peripheral nerve in a canine model

Fred Hetzel, Qun Chen, Kenneth Dole, Dominique Blanc, Lawrence Whalen, Daniel Gould, Zheng Huang

Proceedings Volume 6139, 61390K (2006) https://doi.org/10.1117/12.646317

KEYWORDS: Nerve, Photodynamic therapy, Tissues, Electrodes, Prostate cancer, Prostate, Instrument modeling, Connective tissue, Arteries, Tumor growth modeling

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Proceedings Article | 25 April 2005 Paper

Photoacoustic imaging: consideration of bandwidth of ultrasonic transducer

Yi Tan, Da Xing, Yi Wang, Huaiming Gu, Diwu Yang, Qun Chen

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.589899

KEYWORDS: Transducers, Photoacoustic spectroscopy, Signal detection, Absorption, Photoacoustic imaging, Ultrasonics, Ultrasonography, Breast, Pulsed laser operation, Tissue optics

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Proceedings Article | 25 April 2005 Paper

Fast photo-acoustic imaging based on multi-element linear transducer array

Bangzheng Yin, Da Xing, Diwu Yang, Yi Tan, Qun Chen

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.589926

KEYWORDS: Transducers, Reconstruction algorithms, Signal detection, Tissues, Ultrasonography, Sensors, Acoustics, Detection and tracking algorithms, Multi-element lenses, Imaging systems

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Proceedings Article | 8 April 2005 Paper

Tookad-mediated photodynamic effects on the prostate and its adjacent tissues: in vivo study in canine models

Zheng Huang, Qun Chen, David Luck, Jill Beckers, Dominique Blanc, Fred Hetzel

Proceedings Volume 5689, (2005) https://doi.org/10.1117/12.587872

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Colon, Bladder, Prostate cancer, Nerve, Diffusers, Phase modulation, Light scattering

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Proceedings Article | 4 April 2005 Paper

Dynamic detection of caspase-3 activation during photosensitization by fluorescence resonance energy transfer

Yunxia Wu, Da Xing, Qun Chen, Tongsheng Chen, Yonghong Tang, Qingling Wan

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.588963

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Photodynamic therapy, Luminescence, Venus, Oxygen, Proteins, Tumors, Molecules, Confocal microscopy

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Proceedings Article | 4 April 2005 Paper

An ECL-PCR method for quantitative detection of point mutation

Debin Zhu, Da Xing, Xingyan Shen, Qun Chen, Jinfeng Liu

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.588909

KEYWORDS: Electrodes, Blood, Calibration, Polymers, Magnetism, Quantitative analysis, Signal processing, Adsorption, Solids, Biomedical optics

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Proceedings Article | 4 April 2005 Paper

A novel CL system for PDT therapecitic dosimeter in vitro

Yanfang Qin, Da Xing, Xueyun Zhong, Jing Zhou, Shiming Luo, Qun Chen

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.589546

KEYWORDS: Photodynamic therapy, Oxygen, In vitro testing, Chemiluminescence, Laser therapeutics, Analog electronics, Biological detection systems, Leukemia, Optical filters, Bandpass filters

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Proceedings Article | 4 April 2005 Paper

Chemical luminescence measurement of singlet oxygen generated by photodynamic therapy in solutions in real time

Shiming Luo, Da Xing, Jing Zhou, Yanfang Qin, Qun Chen

Proceedings Volume 5704, (2005) https://doi.org/10.1117/12.589497

KEYWORDS: Photodynamic therapy, Oxygen, Luminescence, Chemiluminescence, Single photon, Photosensitizer targeting, Tissue optics, Optical testing, Analog electronics, Photodetectors

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Proceedings Article | 18 January 2005 Paper

Imaging of activated caspase-3 in living cell by fluorescence resonance energy transfer during photosensitization-induced apoptosis

Yunxia Wu, Da Xing, Qun Chen, Yonghong Tang

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.572773

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Photodynamic therapy, Luminescence, Venus, Optical filters, Cancer, Visible radiation, Proteins, Confocal microscopy

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Proceedings Article | 18 January 2005 Paper

Studies of vascular acting photosensitizer Tookad for the photodynamic therapy of prostate cancer

Zheng Huang, Qun Chen, Dominique Blanc, Fred Hetzel

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.570280

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Plasma, Animal model studies, Blood pressure, Blood, Surgery, Tumor growth modeling

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Proceedings Article | 18 January 2005 Paper

Application of chemiluminescence with FCLA in photodynamic therapy

Yanfang Qin, Da Xing, Xueyun Zhong, Jing Zhou, Shiming Luo, Qun Chen

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.575856

KEYWORDS: Photodynamic therapy, Oxygen, Chemiluminescence, Single photon, Laser therapeutics, Photosensitizer targeting, Medical research, Laser tissue interaction, Cell death, Photomultipliers

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Proceedings Article | 29 July 2004 Paper

High-sensitivity imaging method of singlet oxygen and superoxide anion in photodynamic and sonodynamic actions

Da Xing, Yonghong He, Min Hao, Qun Chen

Proceedings Volume 5486, (2004) https://doi.org/10.1117/12.572049

KEYWORDS: Tumors, Chemiluminescence, Oxygen, Photodynamic therapy, Tissues, Ultrasonography, Sodium, Signal detection, In vitro testing, Luminescence

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Proceedings Article | 14 June 2004 Paper

Chemiluminescence detection of reactive oxygen species during photodynamic therapy

Da Xing, Yanfang Qin, Yunxia Wu, Jin Zhou, Shiming Luo, Yonghong He, Qun Chen

Proceedings Volume 5315, (2004) https://doi.org/10.1117/12.528576

KEYWORDS: Photodynamic therapy, Oxygen, Chemiluminescence, Luminescence, Tissue optics, Microscopy, Carbon monoxide, Tumors, Photosensitizer targeting, Analog electronics

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Proceedings Article | 14 June 2004 Paper

Preclinical studies of vascular acting photosensitizer bacteriopheophorbide for the treatment of prostate cancer

Fred Hetzel, Qun Chen, David Luck, Jill Beckers, Zheng Huang

Proceedings Volume 5315, (2004) https://doi.org/10.1117/12.528379

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Magnetic resonance imaging, Blood, Animal model studies, Bladder, Diffusers, Semiconductor lasers

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Proceedings Article | 8 December 2003 Paper

Studies of a novel photosensitizer Pd-bacteriopheophorbide (Tookad) for the prostate cancer PDT in canine model

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546099

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Tumor growth modeling, Cancer, Blood, Bladder, Colon

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Proceedings Article | 13 June 2003 Paper

Hyperoxygenation enhances the direct tumor cell killing of photofrin-mediated photodynamic therapy

Zheng Huang, Qun Chen, Abdus Shakil, Hua Chen, Jill Beckers, Howard Shapiro, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474147

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues, In vitro testing, Hypoxia, Animal model studies, In vivo imaging, Tissue optics, Sensors

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Proceedings Article | 13 June 2003 Paper

Studies of a novel photosensitizer palladium-bacteriopheophorbide (Tookad) for the treatment of prostate cancer

Zheng Huang, Qun Chen, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, David Luck, Jill Beckers, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474097

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Prostate cancer, Animal model studies, Blood, Tumors, Bladder, Blood pressure, Cancer

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Proceedings Article | 13 June 2003 Paper

Effects of TOOKAD-PDT on canine prostates pre-treated with ionizing radiation

Qun Chen, Zheng Huang, David Luck, Jill Beckers, Nadira Trncic, Susan LaRue, Pierre-Herve Brun, Brian Wilson, Fred Hetzel

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474099

KEYWORDS: Photodynamic therapy, Prostate, Tissues, Tissue optics, Ionizing radiation, Surgery, Radiotherapy, Prostate cancer, Bladder, Collagen

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PDT in prostate cancer will likely be implemented clinically with patients who have failed prior ionizing radiation therapy (RT). The current study is to develop an in vivo model to evaluate the effects of PDT on prostatic tissue after RT. To produce a physiological and anatomical environment in prostate similar to that in patients who have failed RT, canine prostates (n=4) were subjected to a definitive course of ionizing radiation therapy (2.7 Gy x 20 fractions) 5 to 6 months prior to PDT. A laparotomy was performed to expose the prostate for PDT. Second generation photosensitizer Tookad (Palladium-Bacteriopheophorbide, Steba Biotech, The Netherlands) acts primarily on tissue vasculature and is very effective in destroying normal prostatic tissue, as shown by our prior studies. Due to the extremely fast clearance of the photosensitizer, interstitial light irradiation (760 nm, 50-200 J/cm, 150 mW/cm from a 1 cm diffuser fiber) was delivered 4 minutes after the onset of Tookad infusion (i.v. 2.5 mg/ml, 2 mg/kg, total infusion time 10 min). The prostates were harvested for histopathology one week after PDT. At one week, the lesions were characterized by acute hemorrhagic necrosis with patchy sub-capsular hyperemia and edema. The maximum lesion diameter for 50, 100 and 200 J/cm PDT was approximately 15, 20 and 28 mm, respectively. The lesion size is well correlated with light fluence and comparable to that in prostates treated with identical PDT doses but without prior-RT. Under light-microscopy, the PDT induced necrosis is clearly distinguishable from the radiation induced fibrosis. No urethral lesions were observed. Dyer’s Verhoeff stain showed the loss of stromal connective tissue and the acinar collagen in the PDT treated area. There was no noticeable damage on the bladder or underlying colon section. In conclusion, Tookad-PDT can effectively destroy prostate tissue with prior-RT induced fibrosis, thus, may provide an alternative modality for those prostate-cancer patients who have failed RT.

Proceedings Article | 12 September 2002 Paper

Improvement of tumor response to photodynamic therapy by manipulation of tumor oxygenation in an in-vivo model system

Qun Chen, Zheng Huang, Hua Chen, Howard Shapiro, Jill Beckers, Fred Hetzel

Proceedings Volume 4916, (2002) https://doi.org/10.1117/12.482964

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues, Hypoxia, Tissue optics, Electrodes, Animal model studies, Tumor growth modeling, Systems modeling

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Proceedings Article | 6 June 2002 Paper

Clinical studies of photodynamic therapy for malignant brain tumors: Karnofsky score and neurological score in patients with recurrent gloms treated with Photofrin PDT

Paul Muller, Brian Wilson, Lothar Lilge, Victor Yang, Abhay Varma, Arjen Bogaards, Fred Hetzel, Qun Chen, Tim Fullagar, Robert Fenstermaker, Robert Selker, Judith Abrams

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469353

KEYWORDS: Tumors, Photodynamic therapy, Brain, Surgery, Radiotherapy, Gait analysis, Cancer, Chemical elements, Visualization, Sensors

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In our previous phase II studies we treated 112 patients with malignant brain tumors with 2-mg/kg Photofrin i.v. and intra-operative cavitary PDT. We concluded that PDT was safe in patients with newly diagnosed or recurrent supratentorial malignant gliomas. Pathology, performance grade and light dose were significantly related to survival time. In selected patients when an adequate light dose was used survival time improved. The surgical mortality rate was less than 3%. [spie 2000] We have initiated two randomized prospective trials - the first, to determine if the addition of PDT to standard therapy [surgery, radiation and/or chemotherapy] prolongs the survival of patients with newly diagnosed malignant astrocytic tumors; and the second, to determine whether high light dose PDT [120 J/cm²] is superior to low light dose PDT [40 J/cm²] in patients with recurrent malignant astrocytic tumors. To date, 158 patients have been recruited - 72 to the newly diagnosed malignant glioma study and 86 to the recurrent glioma study. In the recurrent glioma study we compared the pre-operative KS and elements of the neurological examination [speech function, visual fields, cognitive function, sensory examination and gait] to the post-operative examinations at hospital discharge. The means were compared by paired student-t test. The KS in 86 of 88 patients with recurrent gliomas were assessable. The mean [s.d.] preoperative and post-operative KS were 82+/- 14 and 79+/- 17, respectively [p=0.003]. The mean decline in KS, although statistically significant, was small and of no clinical importance. The median Karnofsky score changed from 90 to 80. The KS improved in 8 patients; their post-operative average length of stay (alos) was =9.7 days. There was no change in 47 [alos=8.3], a decline of 10 points in 24 [aloc=13.4] and declined by more than 10 points in 7 [alos=23.3]. Three of these 7 patients who had a decline of >10 points improved in follow-up but did not reach their preoperative KS. The data were not available in 2. Elements of the preoperative and discharge neurological examination were assigned a score and compared by a paired t-test. There was a statistically insignificant improvement in the neurological score. A small but statistically significant decline in Karnofsky score was identified post-operatively in these recurrent tumor patients. Their hospital average length of stay increased with declining Karnofsky score. These prospective clinical observations confirmed our previous conclusion that brain tumor PDT was safe. The clinical studies are supported in part by grant CA 43892 awarded by DHHS/NIH/NCI.

Proceedings Article | 6 June 2002 Paper

WSTO9 (TOOKAD) mediated photodynamic therapy as an alternative modality in the treatment of prostate cancer

Qun Chen, Zheng Huang, David Luck, Jill Beckers, Pierre-Herve Brun, Brian Wilson, Avigdor Scherz, Yoram Salomon, Fred Hetzel

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469351

KEYWORDS: Photodynamic therapy, Prostate, Prostate cancer, Tissues, Tissue optics, Bladder, Colon, Animal model studies, Surgery, Tumors

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Proceedings Article | 9 April 2001 Paper

Hyperoxygenation enhances photodynamic therapy tumor cure

Fred Hetzel, Abdus Shakil, Jill Beckers, Qun Chen

Proceedings Volume 4248, (2001) https://doi.org/10.1117/12.424435

KEYWORDS: Photodynamic therapy, Tumors, Oxygen, Hypoxia, In vitro testing, In vivo imaging, Laser irradiation, Animal model studies, Tumor growth modeling, Tissue optics

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Proceedings Article | 9 April 2001 Paper

Photofrin photodynamic therapy for malignant brain tumors

Paul Muller, Brian Wilson, Lothar Lilge, Victor Yang, Fred Hetzel, Qun Chen, Tim Fullagar, Robert Fenstermaker, Robert Selker, Judith Abrams

Proceedings Volume 4248, (2001) https://doi.org/10.1117/12.424454

KEYWORDS: Tumors, Photodynamic therapy, Brain, Surgery, Radiotherapy, Pathology, Optical fibers, Clinical trials, Aluminum, Reflectors

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Proceedings Article | 29 March 2000 Paper

Clinical trials of photodynamic therapy of malignant brain tumors

Paul Muller, Brian Wilson, Lothar Lilge, Victor Yang, Mike Hitchcock, Fred Hetzel, Qun Chen, T. Fullager, Robert Fenstermaker, Robert Selker, Judith Abrams

Proceedings Volume 3909, (2000) https://doi.org/10.1117/12.379894

KEYWORDS: Photodynamic therapy, Tumors, Clinical trials, Brain

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Proceedings Article | 6 July 1999 Paper

Modification of tumor response by manipulation of tumor oxygenation

Qun Chen, Jill Beckers, Fred Hetzel

Proceedings Volume 3592, (1999) https://doi.org/10.1117/12.351506

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues, Hypoxia, Tissue optics, Animal model studies, Electrodes, Diffusion, Cancer

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Proceedings Article | 8 May 1997 Paper

Oxygen effect of photodynamic therapy

Qun Chen, Hua Chen, Juli Murphy, Howard Shapiro, Fred Hetzel

Proceedings Volume 2972, (1997) https://doi.org/10.1117/12.273490

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Skin, Tissues, Resistance, Diffusion, Laser therapeutics, Phototherapy, Hypoxia

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Proceedings Article | 17 May 1996 Paper

Interstitial photodynamic therapy for the prostate: a canine feasibility study

Sugandh Shetty, Larry Sirls, Qun Chen, Fred Hetzel, Joseph Cerny

Proceedings Volume 2671, (1996) https://doi.org/10.1117/12.240024

KEYWORDS: Prostate, Photodynamic therapy, Tissue optics, Prostate cancer, Tumors, Optical properties, Argon ion lasers, Dye lasers, Laser applications, Astatine

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Proceedings Article | 12 May 1995 Paper

Application of wound dressings in dermatology laser procedures

Fred Hetzel, Qun Chen, Greg Hoskins

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209145

KEYWORDS: Absorption, Transmittance, Particles, Dermatology, Laser tissue interaction, Optical testing, Argon ion lasers, Sensors, Temperature metrology, Reflectivity

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Proceedings Article | 1 March 1995 Paper

Photodynamic therapy of normal canine prostate

Qun Chen, Sugandh Shetty, Brian Wilson, Michael Patterson, Larry Heads, Daniel Schultz, Joseph Cerny, H. Chen, Fred Hetzel

Proceedings Volume 2371, (1995) https://doi.org/10.1117/12.203386

KEYWORDS: Photodynamic therapy, Prostate, In vivo imaging, Animal model studies, Tumor growth modeling, Data acquisition, Light

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Proceedings Article | 1 March 1995 Paper

Tumor responses after combined PDT and hyperthermia

Fred Hetzel, H. Chen, Qun Chen

Proceedings Volume 2371, (1995) https://doi.org/10.1117/12.203362

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Tissues

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Proceedings Article | 1 March 1994 Paper

Evaluation of prostatic optical properties and tissue response to photodynamic therapy in a canine model

Sugandh Shetty, Qun Chen, Daniel Schultz, Brian Wilson, Michael Patterson, Fred Hetzel, Joseph Cerny

Proceedings Volume 2078, (1994) https://doi.org/10.1117/12.168682

KEYWORDS: Prostate, Photodynamic therapy, Tissue optics, Tissues, Tumors, Tumor growth modeling, Prostate cancer, Temperature metrology, Optical properties, Optical testing

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Proceedings Article | 18 June 1993 Paper

Photodynamic therapy in prostate cancer: optical dosimetry and response of normal tissue

Qun Chen, Sugandh Shetty, Larry Heads, Frank Bolin, Brian Wilson, Michael Patterson, Larry Sirls, Daniel Schultz, Joseph Cerny, Fred Hetzel

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146314

KEYWORDS: Prostate, Photodynamic therapy, Tissue optics, Prostate cancer, In vivo imaging, Optical properties, Signal attenuation, Tumor growth modeling, Tissues, Tumors

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Proceedings Article | 18 June 1993 Paper

Treatment parameters affecting the response of normal brain to photodynamic therapy

Qun Chen, Michael Chopp, Mary Dereski, Brian Wilson, Michael Patterson, David Kessel, Larry Heads, Fred Hetzel

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146304

KEYWORDS: Brain, Photodynamic therapy, Tumors, Tissue optics, Optical testing, Tumor growth modeling, Biological research, Tissues, Signal attenuation, Therapeutics

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Proceedings Article | 1 June 1991 Paper

In-vivo optical attenuation in normal rat brain and its implication in PDT

Qun Chen, Brian Wilson, Michael Patterson, Michael Chopp, Fred Hetzel

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44054

KEYWORDS: Signal attenuation, Photodynamic therapy, Brain, Tissue optics, Tumors, In vivo imaging, Optical testing, Natural surfaces, Monochromators, Visible radiation

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