Integrated optic biosensor

Anthony A. Boiarski; James R. Busch; Ballwant S. Bhullar; Richard W. Ridgway; Larry S. Miller; A. W. Zulich

doi:10.1117/12.144843

21 May 1993 Integrated optic biosensor

Anthony A. Boiarski, James R. Busch, Ballwant S. Bhullar, Richard W. Ridgway, Larry S. Miller, A. W. Zulich

Proceedings Volume 1886, Fiber Optic Sensors in Medical Diagnostics; (1993) https://doi.org/10.1117/12.144843
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

A micro-sized biosensor is formed using integrated-optic channel waveguides in a Mach- Zehnder interferometer configuration. The device measures refractive index changes on the waveguide surface, so it is called a biorefractometer. With an appropriate overlay or selective coating, the sensor can monitor proteins in blood or pollutants and bio-warfare agents in water. The waveguides are fabricated in a glass substrate using potassium ion exchange. A patterned glass buffer layer defines the interferometer's sensing and reference arms. A silicone-rubber cell arrangement brings sample analytes into contact with proteins immobilized on the integrated-optical waveguide surface. Data obtained for antigen-antibody binding of the proteins human Immunoglobulin-G and staph enterotoxin-B indicate that a 50 - 100 ng/ml concentration levels can be measured in less than ten minutes.

Citation Download Citation

Anthony A. Boiarski, James R. Busch, Ballwant S. Bhullar, Richard W. Ridgway, Larry S. Miller, and A. W. Zulich "Integrated optic biosensor", Proc. SPIE 1886, Fiber Optic Sensors in Medical Diagnostics, (21 May 1993); https://doi.org/10.1117/12.144843

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