Birefringence of healthy in vivo primate RNFL with high sensitivity PS-OCT

Nathaniel Joseph Kemp; Haitham N. Zaatari; Jesung Park; Thomas E. Milner; Henry Grady Rylander III

doi:10.1117/12.588047

18 April 2005 Birefringence of healthy in vivo primate RNFL with high sensitivity PS-OCT

Nathaniel Joseph Kemp, Haitham N. Zaatari, Jesung Park, Thomas E. Milner, Henry Grady Rylander III

Proceedings Volume 5688, Ophthalmic Technologies XV; (2005) https://doi.org/10.1117/12.588047
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Form-birefringent properties of the retinal nerve fiber layer (RNFL) have become increasingly important as investigators strive to provide an improved methodology for glaucoma diagnosis. Techniques such as scanning laser polarimetry (SLP) and polarization-sensitive optical coherence tomography (PS-OCT) are two approaches which directly assess RNFL neurotubules, the sub-cellular structures responsible for form-birefringence and axoplasmic transport in retinal ganglion cell axons. We present a novel algorithm for enhancing the sensitivity of PS-OCT. Enhanced polarization-sensitive OCT (EPS-OCT) is capable of detecting small transformations in polarization typically experienced by light propagating through the thin and weakly birefringent primate RNFL. We report birefringence and nerve fiber orientation measurements for the peripapillary region in healthy in vivo primate RNFL and discuss the implications of the enhanced-sensitivity approach on noninvasive quantification of form-birefringence in glaucoma diagnostics.

Citation Download Citation

Nathaniel Joseph Kemp, Haitham N. Zaatari, Jesung Park, Thomas E. Milner, and Henry Grady Rylander III "Birefringence of healthy in vivo primate RNFL with high sensitivity PS-OCT", Proc. SPIE 5688, Ophthalmic Technologies XV, (18 April 2005); https://doi.org/10.1117/12.588047

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KEYWORDS

Polarization

Birefringence

Optical coherence tomography

Speckle

Poincaré sphere

Nerve

Data modeling

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