Self-operated blood plasma separation using micropump in polymer-based microfluidic device

Won Ick Jang; Kwang Hyo Chung; Hyeon Bong Pyo; Seon Hee Park

doi:10.1117/12.693475

20 December 2006 Self-operated blood plasma separation using micropump in polymer-based microfluidic device

Won Ick Jang, Kwang Hyo Chung, Hyeon Bong Pyo, Seon Hee Park

Proceedings Volume 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III; 641511 (2006) https://doi.org/10.1117/12.693475
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2006, Adelaide, Australia

Abstract

The blood is one of the best indicators of health because blood circulates all body tissues and collects information. The COC(Cyclo Olefin Copolymer) has better various properties than PMMA(Polymethy Mechacrylate) and PC(Polycarbonate) that are widely used in biotechnology field. This paper presents a new method of plasma separation on the COC in terms of surface modification for the development of a disposable protein chip. The blood plasma separation device was composed of a whole blood inlet, microchannel with filtration region of micropillars, micropump with microheater, and a blood cell outlet. Micropump with microheater was designed by ANSYS and flow model in the microchannel was designed by CFD-ACE⁺ simulators. We successfully fabricated a polymer based microfluidic device for blood plasma separation by MEMS(Micro Electro Mechanical System) technology. By using this device, cell-free plasma was successfully obtained through the filtration from a drop of whole blood without external force of a syringe pump.

Citation Download Citation

Won Ick Jang, Kwang Hyo Chung, Hyeon Bong Pyo, and Seon Hee Park "Self-operated blood plasma separation using micropump in polymer-based microfluidic device", Proc. SPIE 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III, 641511 (20 December 2006); https://doi.org/10.1117/12.693475

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