Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents

Veronica Leautaud; Charles R. Horres; Vijayashree S. Bhattar; Michelle D. Williams; Ann M. Gillenwater; Rebecca R. Richards-Kortum

doi:10.1117/12.887755

17 February 2011 Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents

Veronica Leautaud, Charles R. Horres, Vijayashree S. Bhattar, Michelle D. Williams, Ann M. Gillenwater, Rebecca R. Richards-Kortum

Author Affiliations +

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78832H (2011) https://doi.org/10.1117/12.887755
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Early detection is a potential key to improving the survival rates of oral cancer patients and reducing the morbidity associated with treatment. We seek to improve upon methods of detecting of early malignancies with oral brush biopsies by using immunofluorescence-based assessment of the expression of multiple well-described markers commonly overexpressed in oral cancers, such as Epidermal Growth Factor Receptor (EGFR) and Cytokeratin 8 (CK8). Furthermore, since abnormal cells are often scarce in brush biopsy samples, we seek to use magnetic microparticles targeted to these markers as a means of enriching the concentration of abnormal cells. Finally, we plan to conduct a small pilot study using these methods with brush biopsies from patients of the M. D. Anderson Cancer Center Head and Neck Clinic.

Citation Download Citation

Veronica Leautaud, Charles R. Horres, Vijayashree S. Bhattar, Michelle D. Williams, Ann M. Gillenwater, and Rebecca R. Richards-Kortum "Oral cancer screening approach based on labeling exfoliated oral cells with molecularly-targeted optical contrast agents", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832H (17 February 2011); https://doi.org/10.1117/12.887755

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available