High-speed polarization sensitive optical coherence tomography for retinal diagnostics

Biwei Yin; Bingqing Wang; Kalyanramu Vemishetty; Jim Nagle; Shuang Liu; Tianyi Wang; Henry G. Rylander III; Thomas E. Milner

doi:10.1117/12.911447

30 January 2012 High-speed polarization sensitive optical coherence tomography for retinal diagnostics

Biwei Yin, Bingqing Wang, Kalyanramu Vemishetty, Jim Nagle, Shuang Liu, Tianyi Wang, Henry G. Rylander III, Thomas E. Milner

Author Affiliations +

Proceedings Volume 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI; 82132W (2012) https://doi.org/10.1117/12.911447
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We report design and construction of an FPGA-based high-speed swept-source polarization-sensitive optical coherence tomography (SS-PS-OCT) system for clinical retinal imaging. Clinical application of the SS-PS-OCT system is accurate measurement and display of thickness, phase retardation and birefringence maps of the retinal nerve fiber layer (RNFL) in human subjects for early detection of glaucoma. The FPGA-based SS-PS-OCT system provides three incident polarization states on the eye and uses a bulk-optic polarization sensitive balanced detection module to record two orthogonal interference fringe signals. Interference fringe signals and relative phase retardation between two orthogonal polarization states are used to obtain Stokes vectors of light returning from each RNFL depth. We implement a Levenberg-Marquardt algorithm on a Field Programmable Gate Array (FPGA) to compute accurate phase retardation and birefringence maps. For each retinal scan, a three-state Levenberg-Marquardt nonlinear algorithm is applied to 360 clusters each consisting of 100 A-scans to determine accurate maps of phase retardation and birefringence in less than 1 second after patient measurement allowing real-time clinical imaging-a speedup of more than 300 times over previous implementations. We report application of the FPGA-based SS-PS-OCT system for real-time clinical imaging of patients enrolled in a clinical study at the Eye Institute of Austin and Duke Eye Center.

Citation Download Citation

Biwei Yin, Bingqing Wang, Kalyanramu Vemishetty, Jim Nagle, Shuang Liu, Tianyi Wang, Henry G. Rylander III, and Thomas E. Milner "High-speed polarization sensitive optical coherence tomography for retinal diagnostics", Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82132W (30 January 2012); https://doi.org/10.1117/12.911447

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