Lithographic microfabrication of biocompatible polymers for tissue engineering and lab-on-a-chip applications

Evaldas Balciunas; Linas Jonusauskas; Vytautas Valuckas; Daiva Baltriukiene; Virginija Bukelskiene; Roaldas Gadonas; Mangirdas Malinauskas

doi:10.1117/12.923042

8 May 2012 Lithographic microfabrication of biocompatible polymers for tissue engineering and lab-on-a-chip applications

Evaldas Balciunas, Linas Jonusauskas, Vytautas Valuckas, Daiva Baltriukiene, Virginija Bukelskiene, Roaldas Gadonas, Mangirdas Malinauskas

Author Affiliations +

Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 84271X (2012) https://doi.org/10.1117/12.923042
Event: SPIE Photonics Europe, 2012, Brussels, Belgium

Abstract

In this work, a combination of Direct Laser Writing (DLW), PoliDiMethylSiloxane (PDMS) soft lithography and UV lithography was used to create cm- scale microstructured polymer scaolds for cell culture experiments out of dierent biocompatible materials: novel hybrid organic-inorganic SZ2080, PDMS elastomer, biodegradable PEG- DA-258 and SU-8. Rabbit muscle-derived stem cells were seeded on the fabricated dierent periodicity scaolds to evaluate if the relief surface had any eect on cell proliferation. An array of microlenses was fabricated using DLW out of SZ2080 and replicated in PDMS and PEG-DA-258, showing good potential applicability of the used techniques in many other elds like micro- and nano- uidics, photonics, and MicroElectroMechanical Systems (MEMS). The synergetic employment of three dierent fabrication techniques allowed to produce desired objects with low cost, high throughput and precision as well as use materials that are dicult to process by other means (PDMS and PEG-DA-258). DLW is a relatively slow fabrication method, since the object has to be written point-by-point. By applying PDMS soft lithography, we were enabled to replicate laser-fabricated scaolds for stem cell growth and micro-optical elements for lab-on-a-chip applications with high speed, low cost and good reproducible quality.

Citation Download Citation

Evaldas Balciunas, Linas Jonusauskas, Vytautas Valuckas, Daiva Baltriukiene, Virginija Bukelskiene, Roaldas Gadonas, and Mangirdas Malinauskas "Lithographic microfabrication of biocompatible polymers for tissue engineering and lab-on-a-chip applications", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84271X (8 May 2012); https://doi.org/10.1117/12.923042

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