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17 March 2023 Superior image interpretation by morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy: a road to clinical validation
Fabian Placzek, Iwan W. Schie, Florian Knorr, Eliana Cordero, Lara M. Wurster, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Wolfgang Drexler, Jürgen Popp, Rainer A. Leitgeb
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Proceedings Volume PC12353, Advanced Photonics in Urology 2023; PC1235303 (2023) https://doi.org/10.1117/12.2649106
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
As a multimodal approach, optical coherence tomography (OCT) and Raman spectroscopy (RS) are combined. The acquired morpho-molecular tissue information is not only used for improved clinical diagnostics, but furthermore for investigation, interpretation and understanding of signal origin during ex-vivo as well as in-vivo investigation. We present co-localized, endoscopically acquired OCT and RS data on bladder cancer biopsies. Ground truth is histopathological examination. These findings contribute to interpretation of in-vivo data acquired with endoscopic imaging systems. This approach not only opens a new way of interpretation of both modalities but enables access to clinical relevant information, which is nowadays not available in-situ.
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Fabian Placzek, Iwan W. Schie, Florian Knorr, Eliana Cordero, Lara M. Wurster, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Wolfgang Drexler, Jürgen Popp, and Rainer A. Leitgeb "Superior image interpretation by morpho-molecular signal correlation between optical coherence tomography and Raman spectroscopy: a road to clinical validation", Proc. SPIE PC12353, Advanced Photonics in Urology 2023, PC1235303 (17 March 2023); https://doi.org/10.1117/12.2649106
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KEYWORDS
Optical coherence tomography
Raman spectroscopy
Roads
Diagnostics
In vivo imaging
Tissue optics
Endoscopy
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