Wideband micromechanical spectroscopy of biopolymer constructs and tissue specimens with laser speckle microrheology (Conference Presentation)

Nichaluk Leartprapun; Brandon C. Matthews; Seemantini K. Nadkarni

doi:10.1117/12.2650908

15 March 2023 Wideband micromechanical spectroscopy of biopolymer constructs and tissue specimens with laser speckle microrheology (Conference Presentation)

Nichaluk Leartprapun, Brandon C. Matthews, Seemantini K. Nadkarni

Author Affiliations +

Proceedings Volume PC12381, Optical Elastography and Tissue Biomechanics X; PC123810F (2023) https://doi.org/10.1117/12.2650908
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Biological tissues exhibit distinct viscoelastic behavior across multiple frequency scales. Biophysical interactions between cells and extracellular matrix across this spectrum play an important role in governing many pathophysiological processes. We implemented Laser Speckle Microrheology (LSM) to map and measure frequency-dependent viscous and elastic moduli in tumor specimens and ECM constructs up to the sub-MHz regime. We identified distinct frequency-dependent responses in both elasticity and viscosity across multiple regimes, lending a unique source of micromechanical contrast in tissues. Thus, micromechanical spectroscopy with LSM may provide invaluable biomechanical insights that are inaccessible when solely characterizing elasticity over a limited frequency scale.

Conference Presentation

Citation Download Citation

Nichaluk Leartprapun, Brandon C. Matthews, and Seemantini K. Nadkarni "Wideband micromechanical spectroscopy of biopolymer constructs and tissue specimens with laser speckle microrheology (Conference Presentation)", Proc. SPIE PC12381, Optical Elastography and Tissue Biomechanics X, PC123810F (15 March 2023); https://doi.org/10.1117/12.2650908

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