Quantifying structural and functional corneal nerve patterns in evaporative dry eye disease

Maryse Lapierre-Landry; Matthew McPheeters; Made Airanthi Kusuma Widjaja-Adhi; Eric Lu; David L. Wilson; Marcin Golczak; Michael W. Jenkins

doi:10.1117/12.3005679

13 March 2024 Quantifying structural and functional corneal nerve patterns in evaporative dry eye disease

Maryse Lapierre-Landry, Matthew McPheeters, Made Airanthi Kusuma Widjaja-Adhi, Eric Lu, David L. Wilson, Marcin Golczak, Michael W. Jenkins

Author Affiliations +

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240U (2024) https://doi.org/10.1117/12.3005679
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We propose a new toolset to characterize the role of corneal nerves in ocular conditions such as dry eye disease (DED). By automating analysis (nerve segmentation, density, detection of whorl patterns and nerve beading) we quantify the nerve structure over whole ex vivo corneas in a mouse model of evaporative DED. We also created a mouse line of DED with genetically encoded calcium markers and successfully imaged neural activity over time in live corneas. This combined structural and functional quantitative approach will further our understanding of corneal nerves in disease and accelerate the development of novel therapies.

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Citation Download Citation

Maryse Lapierre-Landry, Matthew McPheeters, Made Airanthi Kusuma Widjaja-Adhi, Eric Lu, David L. Wilson, Marcin Golczak, and Michael W. Jenkins "Quantifying structural and functional corneal nerve patterns in evaporative dry eye disease", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240U (13 March 2024); https://doi.org/10.1117/12.3005679

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