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Alterations in tissue mechanical properties have emerged as not merely a symptom of cancer but a decisive regulator of various oncogenic processes. The tumor microenvironment exhibits a combination of elastic and viscous traits spanning a wide frequency spectrum, leading to a perceived paradox of both matrix stiffening and ‘liquidization’ that coexist during malignant transformation and metastasis. Yet, seminal mechanobiological studies have largely relied on a single mechanical descriptor of elasticity. We present wideband laser Speckle rHEologicAl micRoscopy (SHEAR) to investigate the elastic and viscous spectral signatures that exist over >5 decades of frequencies in various types of clinical tumor specimens.
Nichaluk Leartprapun,Jiyoon Koh, andSeemantini K. Nadkarni
"Investigating frequency-dependent viscoelastic spectra of the tumor microenvironment with wideband laser speckle rheological microscopy", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440P (13 March 2024); https://doi.org/10.1117/12.3002809
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Nichaluk Leartprapun, Jiyoon Koh, Seemantini K. Nadkarni, "Investigating frequency-dependent viscoelastic spectra of the tumor microenvironment with wideband laser speckle rheological microscopy," Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440P (13 March 2024); https://doi.org/10.1117/12.3002809