KEYWORDS: Optical coherence tomography, Pathology, Cancer, Tumor growth modeling, Tissues, Tissue optics, Position sensors, In vivo imaging, Data processing, Birefringence
Real-time assessment of tissue morphology and function is a pressing clinical need. We present a low cost OCT probe based on combined position sensor feedback, as well as a data processing algorithm that enables real-time display of tissue morphology and birefringence. The preliminary evaluation of this instrument on various biological specimens has demonstrated its capability for real-time diagnosis. Its preclinical assessment in vivo on animal models of cancer was performed at MD Anderson Cancer Center. Reliable assessment of tissue morphology and birefringence has been successfully demonstrated.
In this paper we report the use of a novel multimodal imaging hand-held probe for guiding laser and radiotherapy on nonmelanoma skin cancers (NMSCs) patients. This probe combines the capability of reflectance confocal microscopy (RCM) with that of Optical Coherence Tomography (OCT) to reliably detect cancer markers and measure cancer depth of invasion. These capabilities have shown to be very effective in accurately measuring cancer margins and guiding the therapy.
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