Prof. Chong Xie Profile

Prof. Chong Xie

at Univ of Texas at Austin

SPIE Involvement:

Author

Publications (2)

SPIE Journal Paper | 7 January 2022 Open Access

Chronic co-implantation of ultraflexible neural electrodes and a cranial window

Rongkang Yin, Brian Noble, Fei He, Pavlo Zolotavin, Haad Rathore, Yifu Jin, Nicole Sevilla, Chong Xie, Lan Luan

NPh, Vol. 9, Issue 03, 032204, (January 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.3.032204

KEYWORDS: Cranial windows, Electrodes, Brain, Tungsten, Skull, Glasses, Optical imaging, Nickel, Neurophotonics, Bone

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Significance: Electrophysiological recording and optical imaging are two prevalent neurotechnologies with complementary strengths, the combined application of which can significantly improve our capacity in deciphering neural circuits. Flexible electrode arrays can support longitudinal optical imaging in the same brain region, but their mechanical flexibility makes surgical preparation challenging. Here, we provide a step-by-step protocol by which an ultraflexible nanoelectronic thread is co-implanted with a cranial window in a single surgery to enable chronic, dual-modal measurements. Aim: The method uses 1-μm-thick polymer neural electrodes which conform to the site of implantation. The mechanical flexibility of the probe allows bending without breaking and enables long-lasting electrophysiological recordings of single-unit activities and concurrent, high-resolution optical imaging through the cranial window. Approach: The protocol describes methods and procedures to co-implant an ultraflexible electrode array and a glass cranial window in the mouse neocortex. The implantation strategy includes temporary attachment of flexible electrodes to a retractable tungsten-microwire insertion shuttle, craniotomy, stereotaxic insertion of the electrode array, skull fixation of the cranial window and electrode, and installation of a head plate. Results: The resultant implant allows simultaneous interrogation of brain activity both electrophysiologically and optically for several months. Importantly, a variety of optical imaging modalities, including wide-field fluorescent imaging, two-photon microscopy, and functional optical imaging, can be readily applied to the specific brain region where ultraflexible electrodes record from. Conclusions: The protocol describes a method for co-implantation of ultraflexible neural electrodes and a cranial window for chronic, multimodal measurements of brain activity in mice. Device preparation and surgical implantation are described in detail to guide the adaptation of these methods for other flexible neural implants and cranial windows.

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Proceedings Article | 9 March 2020 Presentation

longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)

Fei He, Colin Sullender, Hanlin Zhu, Theresa Jones, Chong Xie, Andrew Dunn, Lan Luan

Proceedings Volume 11226, 1122618 (2020) https://doi.org/10.1117/12.2546187

KEYWORDS: Brain mapping, Mouse models, Blood circulation, Brain, Cerebral blood flow, Hemodynamics, Nanoelectronics, Tissue optics, Optical imaging, Imaging systems

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