Dr. Georg Schuele Profile

Dr. Georg Schuele

Head of Product, Device R&D at Lumenex Bio

SPIE Involvement:

Conference Chair | Editor | Author

Publications (21)

SPIE Journal Paper | 18 December 2015 Open Access

Finesse of transparent tissue cutting by ultrafast lasers at various wavelengths

Jenny Wang, Georg Schuele, Daniel Palanker

JBO, Vol. 20, Issue 12, 125004, (December 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.12.125004

KEYWORDS: Laser cutting, Femtosecond phenomena, Cavitation, Proteins, Laser tissue interaction, Laser damage threshold, Excimer lasers, Laser vision correction, Ultraviolet radiation, Scanning electron microscopy

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SPIE Journal Paper | 11 September 2015 Open Access

Safety of cornea and iris in ocular surgery with 355-nm lasers

Jenny Wang, Jae Lim Chung, Georg Schuele, Alexander Vankov, Roopa Dalal, Michael Wiltberger, Daniel Palanker

JBO, Vol. 20, Issue 09, 095005, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.095005

KEYWORDS: Cornea, Iris, Laser vision correction, Laser damage threshold, Safety, Laser safety, Iris recognition, Laser therapeutics, Eye, Surgery

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Proceedings Article | 5 March 2015 Paper

Role of molecular photodissociation in ultrafast laser surgery

Jenny Wang, Georg Schuele, Phil Huie, Daniel Palanker

Proceedings Volume 9321, 932107 (2015) https://doi.org/10.1117/12.2077004

KEYWORDS: Laser cutting, Femtosecond phenomena, Proteins, Cavitation, Tissues, Pulsed laser operation, Laser therapeutics, Surgery, Laser damage threshold, Ultrafast lasers

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Proceedings Article | 26 March 2013 Paper

Ocular safety limits for 1030nm femtosecond laser cataract surgery

Jenny Wang, Christopher Sramek, Yannis Paulus, Daniel Lavinsky, Georg Schuele, Dan Anderson, David Dewey, Daniel Palanker

Proceedings Volume 8567, 856708 (2013) https://doi.org/10.1117/12.2001895

KEYWORDS: Laser therapeutics, Surgery, Safety, Eye, Laser damage threshold, Eye models, Absorption, Femtosecond phenomena, Retina, Tissues

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SPIE Journal Paper | 14 September 2012 Open Access

Retinal safety of near-infrared lasers in cataract surgery

Jenny Wang, Christopher Sramek, Yannis Paulus, Daniel Lavinsky, Georg Schuele, Dan Andersen, David Dewey, Daniel Palanker

JBO, Vol. 17, Issue 9, 095001, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.9.095001

KEYWORDS: Laser damage threshold, Surgery, Laser therapeutics, Laser safety, Safety, Laser vision correction, Retina, Eye, Absorption, Beam shaping

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SPIE Journal Paper | 1 February 2011 Open Access

Improving the therapeutic window of retinal photocoagulation by spatial and temporal modulation of the laser beam

Christopher Sramek, Daniel Palanker, Loh-Shan Leung, Theodore Leng, Yannis Paulus, Jefferson Brown, Georg Schuele

JBO, Vol. 16, Issue 02, 028004, (February 2011) https://doi.org/10.1117/12.10.1117/1.3542045

KEYWORDS: Modulation, Beam shaping, Laser coagulation, Eye, Retina, Pulsed laser operation, Laser therapeutics, Laser systems engineering, Scattering, Laser damage threshold

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Proceedings Article | 3 March 2010 Paper

Selective retinal therapy with a continuous line scanning laser

Yannis Paulus, ATul Jain, Ray Gariano, Hiroyuki Nomoto, Georg Schuele, Christopher Sramek, Resmi Charalel, Daniel Palanker

Proceedings Volume 7550, 75500W (2010) https://doi.org/10.1117/12.840574

KEYWORDS: Laser therapeutics, Visibility, Retina, Laser coagulation, Safety, Angiography, Pulsed laser operation, Laser safety, Image segmentation, Eye

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Proceedings Article | 7 March 2006 Paper

Noninvasive dosimetry and monitoring of TTT using spectral imaging

G. Schuele, F. Molnar, D. Yellachich, E. Vitkin, L. Perelman, D. Palanker

Proceedings Volume 6138, 61381G (2006) https://doi.org/10.1117/12.642338

KEYWORDS: Reflectivity, Laser scattering, Imaging spectroscopy, Scattering, Spectroscopy, Visible radiation, Light scattering, Image analysis, Blood, Absorption

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SPIE Journal Paper | 1 November 2005 Open Access

Optoacoustic real-time dosimetry for selective retina treatment

Georg Schuele, Hanno Elsner, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

JBO, Vol. 10, Issue 06, 064022, (November 2005) https://doi.org/10.1117/12.10.1117/1.2136327

KEYWORDS: Angiography, Acoustics, In vitro testing, Retina, Pulsed laser operation, Eye, Transducers, Laser damage threshold, Sensors, Visualization

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SPIE Journal Paper | 1 September 2005 Open Access

Optical spectroscopy noninvasively monitors response of organelles to cellular stress

Georg Schuele, Edward Vitkin, Philip Huie, Caitlin O'Connell-Rodwell, Daniel Palanker, Lev Perelman

JBO, Vol. 10, Issue 05, 051404, (September 2005) https://doi.org/10.1117/12.10.1117/1.2075207

KEYWORDS: Scattering, Light scattering, Particles, Refractive index, Optical spectroscopy, Transmission electron microscopy, Spectroscopy, Scatter measurement, Mie scattering, Medicine

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Proceedings Article | 18 April 2005 Paper

Optical monitoring of thermal effects in the retina during laser exposure

Georg Schuele, Philip Huie, Dimitri Yellachich, Fanni Molnar, Caitlin O’Conell-Rodwell, Edward Vitkin, Lev Perelman, Daniel Palanker

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.591068

KEYWORDS: Light scattering, Scattering, Refractive index, Particles, Transmission electron microscopy, Mie scattering, Spectroscopy, Proteins, Temperature metrology, Thermography

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Proceedings Article | 13 July 2004 Paper

Optoacoustic online dosimetry during selective RPE treatment

Georg Schuele, Hanno Elsner, Hans Hoerauf, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.529384

KEYWORDS: Angiography, Acoustics, In vitro testing, Transducers, Laser damage threshold, Eye, Retina, Sensors, Pulsed laser operation, Visualization

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Introduction: The selective RPE treatment (SRT) is a new method, which targets retinal diseases associated with disorders in the retinal pigment epithelium (RPE). By applying a train of μs laser pulses, it is possible to selectively damage RPE cells while sparing the adjacent photoreceptors and the neural retina. Due to the ophthalmoscopic invisibility of the RPE effects we investigated an optoacoustic (OA) on-line dosimetry system to monitor RPE damage non-invasively. Material and Methods: For in vitro experiments porcine RPE was irradiated with a Nd:YLF laser pulse train (527nm, 1.7μs, 5-40μJ, 30 pulses, 100 Hz). Pressure waves (optoacoustic transients) generated at the RPE were measured with a piezoelectric transducer. The RPE cell damage was visualised by fluorescence microscopy by means of the vitality stain CalceinAM. During 27 patient treatments (527nm, 1.7μs, 50-150μJ, 30 pulses, 100 Hz) the optoacoustic signals were measured with an ultrasonic transducer embedded in the contact lens. The RPE leakage was visualized by fluorescein and ICG angiography. Results: In vitro: Below the RPE cell damage threshold, the optoacoustic transients from each single pulse are almost similar. With RPE damage, fluctuations of the individual transients are observed during the pulse train. These fluctuations can be explained by statistical irregular microbubble formation around the strong light absorbing melanosomes inside the RPE cells, which occur after the temperature exceeds the vaporization threshold. The transient microbubbles probably lead to RPE cell disruption. An optoacoustic value (OA-value) calculated from the fluctuations was defined in order to assess RPE damage. Patient treatment: If optoacoustic pulse-to-pulse fluctuations were measured, RPE leakage was observed in fluorescein and ICG angiography. In 96% of the irradiated areas, RPE-leakage in fluorescein angiography and OA-value correlated. The stronger the optoacoustic pulse-to-pulse fluctuations, thus the higher the OA-value, the more intense angiographic leakage was observed in ICG-angiography. Conclusion: A non-invasive optoacoustic on-line dosimetry control to monitor RPE damage during SRT was developed. In order to avoid invasive angiography, it is currently evaluated in a multicenter clinical SRT study.

Proceedings Article | 13 July 2004 Paper

Noninvasive monitoring of the thermal stress in RPE using light-scattering spectroscopy

Georg Schule, Philip Huie, Alexander Vankov, Edward Vitkin, Hui Fang, Eugene Hanlon, Lev Perelman, Daniel Palanker

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.529415

KEYWORDS: Light scattering, Scattering, Spectroscopy, Temperature metrology, Laser therapeutics, Refractive index, Photodynamic therapy, Optical testing, Lamps, Laser coagulation

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SPIE Journal Paper | 1 January 2004 Open Access

Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation

Georg Schuele, Gereon Huttmann, Carsten Framme, Johann Roider, Ralf Brinkmann

JBO, Vol. 9, Issue 01, (January 2004) https://doi.org/10.1117/12.10.1117/1.1627338

KEYWORDS: Temperature metrology, Pulsed laser operation, In vitro testing, Eye, Absorption, Continuous wave operation, Laser irradiation, Transducers, Laser therapeutics, Retina

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Proceedings Article | 27 June 2002 Paper

Selective damage of pigmented cells by means of a rapidly scanned cw laser beam

Ralf Brinkmann, Norbert Koop, Mustafa Oezdemir, Clemens Alt, Georg Schuele, Charles Lin, Reginald Birngruber

Proceedings Volume 4617, (2002) https://doi.org/10.1117/12.472538

KEYWORDS: Laser damage threshold, Retina, Laser scanners, Pulsed laser operation, Continuous wave operation, Eye, Laser tissue interaction, Luminescence, Angiography, Scanners

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Proceedings Article | 13 June 2002 Paper

Noninvasive temperature measurements during laser irradiation of the retina with optoacoustic techniques

Georg Schuele, Gereon Huettmann, Ralf Brinkmann

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470601

KEYWORDS: Temperature metrology, In vitro testing, Pulsed laser operation, Continuous wave operation, Transducers, Calibration, Absorption, Laser therapeutics, Laser beam diagnostics, Laser irradiation

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Proceedings Article | 13 June 2002 Paper

In-vivo and in-vitro selective targeting of the retinal pigment epithelium using a laser-scanning device

Clemens Alt, Carsten Framme, Susanne Schnell, Georg Schuele, Ralf Brinkmann, Charles Lin

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470607

KEYWORDS: Angiography, In vitro testing, Retina, Eye, Laser coagulation, In vivo imaging, Continuous wave operation, Lamps, Phase modulation, Laser therapeutics

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Proceedings Article | 26 October 2001 Paper

Optoacoustic detection of selective RPE cell damage during us-laser irradiation

Georg Schuele, Elke Joachimmeyer, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446507

KEYWORDS: Laser damage threshold, Pulsed laser operation, Transducers, Neodymium lasers, Lamps, Acoustics, Ophthalmology, Tissue optics, Astatine, Photodynamic therapy

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Proceedings Article | 15 June 2001 Paper

Optoacoustic control system for selective treatment of the retinal pigment epithelium

Georg Schuele, Elke Joachimmeyer, Carsten Framme, Johann Roider, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 4256, (2001) https://doi.org/10.1117/12.429323

KEYWORDS: Transducers, Laser damage threshold, In vitro testing, Angiography, Retina, Control systems, Neodymium lasers, Pulsed laser operation, Ultrasonics, Fiber lasers

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Proceedings Article | 13 June 2000 Paper

Optoacoustic measurements during us irradiation of the retinal pigment epithelium

Georg Schuele, Gereon Huettmann, Johann Roider, Christopher Wirbelauer, Reginald Birngruber, Ralf Brinkmann

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388090

KEYWORDS: Temperature metrology, Pulsed laser operation, Transducers, Picosecond phenomena, Laser tissue interaction, Glasses, Ophthalmology, Neodymium lasers, Signal generators, Ultrasonics

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Proceedings Article | 4 January 1999 Paper

Spectral IR tissue diagnostics with photothermal detection

Georg Schuele, B. Schmitz, Rudolf Steiner

Proceedings Volume 3565, (1999) https://doi.org/10.1117/12.335794

KEYWORDS: Tissues, Tissue optics, Diagnostics, Skin, Fused deposition modeling, FT-IR spectroscopy, Polymethylmethacrylate, Absorption, Diffusion, Modulation

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Showing 5 of 21 publications

Proceedings Volume Editor (2)

SPIE Conference Volume | 2 April 2024

Ophthalmic Technologies XXXIV

SPIE Conference Volume | 26 April 2023

Ophthalmic Technologies XXXIII

Conference Committee Involvement (17)

Ophthalmic Technologies XXXV

25 January 2025 | San Francisco, California, United States

Ophthalmic Technologies XXXIV

27 January 2024 | San Francisco, California, United States

Ophthalmic Technologies XXXIII

28 January 2023 | San Francisco, California, United States

Ophthalmic Technologies XXXII

22 January 2022 | San Francisco, California, United States

Ophthalmic Technologies XXXI

6 March 2021 | Online Only, California, United States

Ophthalmic Technologies XXX

1 February 2020 | San Francisco, California, United States

Ophthalmic Technologies XXIX

2 February 2019 | San Francisco, California, United States

Ophthalmic Technologies XXVIII

27 January 2018 | San Francisco, California, United States

Ophthalmic Technologies XXVII

28 January 2017 | San Francisco, California, United States

Ophthalmic Technologies XXVI

13 February 2016 | San Francisco, California, United States

Ophthalmic Technologies XXV

7 February 2015 | San Francisco, California, United States

Ophthalmic Technologies XXIV

1 February 2014 | San Francisco, California, United States

Ophthalmic Technologies XXIII

2 February 2013 | San Francisco, California, United States

Ophthalmic Technologies XXII

21 January 2012 | San Francisco, California, United States

Ophthalmic Technologies XXI

22 January 2011 | San Francisco, California, United States

Ophthalmic Technologies XX

23 January 2010 | San Francisco, California, United States

Ophthalmic Technologies XIX

24 January 2009 | San Jose, California, United States

Showing 5 of 17 Conference Committees

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