Prof. Jing Yong Ye Profile

Prof. Jing Yong Ye

Professor at Univ of Texas at San Antonio

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Author

Publications (38)

Proceedings Article | 16 March 2023 Presentation + Paper

Label-free quantification of POEGMA-144 polymerization and thermal response via PC-TIR biosensor

Luis Trabucco, Henry Guess, Joshua Chaj Ulloa, Maisha Ahmed, Sean McFadden, Rohini Thevi Guntnur, Nikolay Akimov, Gabriela Romero, Jing Yong Ye

Proceedings Volume 12391, 123910G (2023) https://doi.org/10.1117/12.2650428

KEYWORDS: Polymers, Sensors, Biosensors, Polymerization, Polymeric sensors, MATLAB, CMOS sensors, Refractive index, Polydimethylsiloxane, Molecules, Thermal analysis

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Proceedings Article | 2 March 2022 Presentation + Paper

Functionalization of a photonic crystal biosensor with modified aptamers for the detection of cardiac biomarkers

Luis Trabucco, Christian Gonzalez, Ashley Ridoutt, Ayesha Kishwar, Joshua Chaj-Ulloa, Mohammed Attia, Nevin Yazdani, Nikolay Akimov, Jing Yong Ye

Proceedings Volume 11972, 119720E (2022) https://doi.org/10.1117/12.2609898

KEYWORDS: Sensors, Ultraviolet radiation, Biosensors, Photonic crystals, Glasses, Target detection, Molecules, Chemical analysis, Microfluidics, Proteins

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Proceedings Article | 20 February 2020 Paper

Enhancement of label-free biosensing of cardiac troponin I

Chase Christenson, Kwaku Baryeh, Samad Ahadian, Rohollah Nasiri, Mehmet Dokmeci, Marcus Goudie, Ali Khademhosseini, Jing Yong Ye

Proceedings Volume 11251, 112512J (2020) https://doi.org/10.1117/12.2546979

KEYWORDS: Sensors, Molecules, Photonic crystals, Chemical elements, Biosensing, Heart, Plasma, Microfluidics, Blood, Semiconducting wafers

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Proceedings Article | 20 February 2020 Paper

Prostate cancer epithelial mesenchymal transition by TGF-β1 exposure monitored with a photonic crystal biosensor

Melissa Cadena, Frank DeLuna, Kwaku Baryeh, Lu-Zhe Sun, Jing Yong Ye

Proceedings Volume 11251, 1125126 (2020) https://doi.org/10.1117/12.2544113

KEYWORDS: Prostate cancer, Biosensors, Proteins, Photonic crystals, Refractive index, Sensors, Biosensing, Cancer, Water, Reflectivity

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Proceedings Article | 17 February 2020 Presentation + Paper

Calcium-sensitive photoacoustic probe for noninvasive extracellular calcium monitoring

Frank DeLuna, Nicholas McMahon, Mayeul Collot, Jing Yong Ye

Proceedings Volume 11240, 1124018 (2020) https://doi.org/10.1117/12.2545161

KEYWORDS: Calcium, Photoacoustic spectroscopy, Absorption, Near infrared, Tissue optics, Ions, Photoacoustic imaging, Signal generators, Brain

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Proceedings Article | 4 March 2019 Presentation + Paper

Cellular refractive index comparison of various prostate cancer and noncancerous cell lines via photonic-crystal biosensor

Frank DeLuna, Melissa Cadena, Bingzhi Wang, Lu-Zhe Sun, Jing Yong Ye

Proceedings Volume 10881, 108810K (2019) https://doi.org/10.1117/12.2507505

KEYWORDS: Biosensors, Prostate cancer, Prostate, Refractive index, Biomedical optics, Sensors, Optical microcavities, Prisms, Reflectivity

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Proceedings Article | 26 February 2019 Presentation + Paper

Innovative computer vision approach to 3D bladder model reconstruction from flexible cystoscopy

Nestor Orlando Falcon, Sorush Ranjbar, Exal Cisneros, Bao Vu, Austin Schoppe, Pedro Sanchez, Yufang Jin, JingYong Ye, Yusheng Feng, Dharam Kaushik, R. Lyle Hood

Proceedings Volume 10852, 1085207 (2019) https://doi.org/10.1117/12.2510725

KEYWORDS: Bladder, 3D modeling, Video, Cystoscopy, Machine vision, Computer vision technology, 3D image processing, Cameras

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Proceedings Article | 23 February 2018 Presentation + Paper

Fabrication and characterization of thermo-responsive gold nanorod assemblies

Gilbert Bustamante, Katherine Carrizales, Frank DeLuna, Nicolas Large, Jing Yong Ye

Proceedings Volume 10507, 105070B (2018) https://doi.org/10.1117/12.2288554

KEYWORDS: Nanorods, Absorption, Gold, Polymers, Plasmons, Finite-difference time-domain method

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Proceedings Article | 20 February 2018 Presentation + Paper

Label-free in vitro prostate cancer cell detection via photonic-crystal biosensor

Frank DeLuna, XiaoFei Ding, Ismael Sagredo, Gilbert Bustamante, Lu-Zhe Sun, Jing Yong Ye

Proceedings Volume 10504, 105040D (2018) https://doi.org/10.1117/12.2288019

KEYWORDS: Biosensors, Prostate cancer, Optical microcavities, Biomedical optics, Refractive index, Prostate, In vitro testing, Photodetectors, Prisms, Reflectivity

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Proceedings Article | 20 February 2018 Presentation + Paper

Label-free detection of protein biomolecules secreted from a heart-on-a-chip model for drug cardiotoxicity evaluation

Frank DeLuna, Yu Shrike Zhang, Gilbert Bustamante , Le Li, Matthew Lauderdale, Mehmet Dokmeci, Ali Khademhosseini, Jing Yong Ye

Proceedings Volume 10510, 1051003 (2018) https://doi.org/10.1117/12.2290399

KEYWORDS: Biosensors, Proteins, Toxicity, Animal model studies, Microfluidics, Biological research, Statistical modeling, Biomedical optics, Silica, CCD cameras

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Proceedings Article | 19 February 2018 Presentation + Paper

In-vivo fluorescence detection of breast cancer growth factor receptors by fiber-optic probe

Gilbert Bustamante, Bingzhi Wang, Frank DeLuna, LuZhe Sun, Jing Yong Ye

Proceedings Volume 10489, 104890E (2018) https://doi.org/10.1117/12.2290464

KEYWORDS: Luminescence, Tumors, Receptors, Breast cancer, In vivo imaging, Optical filters, Absorbance, Fiber optics, Tissues, Fiber lasers

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SPIE Journal Paper | 6 February 2018 Open Access

Limulus amoebocyte lysate test via an open-microcavity optical biosensor

Jonathan Scudder, Jing Yong Ye

JBO, Vol. 23, Issue 02, 027001, (February 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.027001

KEYWORDS: Sensors, Biosensors, Optical biosensors, Reflectivity, In vitro testing, Statistical analysis, Biological research, Biomedical optics, Blood, Plasma

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Proceedings Article | 16 February 2017 Paper

Evaluation of a novel label-free photonic-crystal biosensor imaging system for the detection of prostate cancer cells

Frank DeLuna, XiaoFie Ding, Lu-Zhe Sun, Jing Yong Ye

Proceedings Volume 10068, 100681H (2017) https://doi.org/10.1117/12.2249630

KEYWORDS: Prostate cancer, Biosensors, Imaging systems, Biomedical optics, Optical microcavities, Prostate, Reflection, Refractive index, Photodetectors, Biological research, Sensors, Photonic crystals, Biopsy

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SPIE Journal Paper | 23 November 2016 Open Access

Distinguishing tracheal and esophageal tissues with hyperspectral imaging and fiber-optic sensing

Corinne Nawn, Brian Souhan, Robert Carter, Caitlin Kneapler, Nicholas Fell, Jing Yong Ye

JBO, Vol. 21, Issue 11, 117004, (November 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.11.117004

KEYWORDS: Tissues, Reflectivity, Fiber optics, Esophagus, Fiber optics sensors, Hyperspectral imaging, Cameras, Light sources, Visualization, Sensors

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Proceedings Article | 22 April 2016 Presentation + Paper

Label-free detection of protein molecules secreted from an organ-on-a-chip model for drug toxicity assays

Andres Morales, Yu Zhang, Julio Aleman, Parissa Alerasool, Mehmet Dokmeci, Ali Khademhosseini, Jing Yong Ye

Proceedings Volume 9725, 972508 (2016) https://doi.org/10.1117/12.2212971

KEYWORDS: Proteins, Molecules, Animal model studies, Sensors, Toxicity, Tissues, Photonic crystals, Biosensors, Silica, CCD image sensors

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Proceedings Article | 7 March 2016 Paper

Spectral characterization of tracheal and esophageal tissues using a hyperspectral camera and fiber optic sensors

Corinne Nawn, Brian Souhan, Robert Carter, Caitlin Kneapler, Nicholas Fell, Jing Yong Ye

Proceedings Volume 9702, 970212 (2016) https://doi.org/10.1117/12.2211406

KEYWORDS: Tissues, Cameras, Fiber optics sensors, Fiber optics, Lung, Visualization, Esophagus, Reflectivity, Ultraviolet radiation, Optical fibers, Light sources, Calibration, In vivo imaging

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Proceedings Article | 5 March 2015 Paper

Utilizing an open-microcavity optoacoustic sensor for spectroscopic determination of methemoglobin concentration

Ralph Peterson, Kavya Kadugodinandareddy, Vinitha Karunakaran, Casey Whitney, Jian Ling, Jing Yong Ye

Proceedings Volume 9319, 93191N (2015) https://doi.org/10.1117/12.2080119

KEYWORDS: Sensors, Photoacoustic spectroscopy, Latex, Absorption, Spectroscopy, Scattering, Laser beam diagnostics, Chromophores, Ultrasonography, Spectrophotometry

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SPIE Journal Paper | 1 December 2011 Open Access

Detection of anthrax lef with DNA-based photonic crystal sensors

Bailin Zhang, Ralph Petersen, Syed Hussain, Jing Yong Ye, Shatha Dallo, Tao Weitao

JBO, Vol. 16, Issue 12, 127006, (December 2011) https://doi.org/10.1117/12.10.1117/1.3662460

KEYWORDS: Sensors, Polymethylmethacrylate, Photonic crystals, Biosensors, Molecules, Silica, Reflectivity, Biosensing, Fabry–Perot interferometers, Biomedical optics

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SPIE Journal Paper | 1 January 2011 Open Access

Broadband optical ultrasound sensor with a unique open-cavity structure

Colin Chow, Yun Zhou, Yunbo Guo, Theodore Norris, Xueding Wang, Cheri Deng, Jing Yong Ye

JBO, Vol. 16, Issue 1, 017001, (January 2011) https://doi.org/10.1117/12.10.1117/1.3528014

KEYWORDS: Sensors, Ultrasonography, Ultrasonics, Reflectivity, Dielectrics, Polymethylmethacrylate, Signal detection, Silica, Coating, Transducers

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Proceedings Article | 9 November 2010 Paper

Cell flow analysis with a two-photon fluorescence fiber probe

Yu-Chung Chang, Jing Yong Ye, Thommey Thomas, James Baker, Theodore Norris

Proceedings Volume 7845, 78450U (2010) https://doi.org/10.1117/12.870295

KEYWORDS: Fluorescence correlation spectroscopy, Blood, Velocity measurements, Luminescence, In vivo imaging, Green fluorescent protein, Flow cytometry, Statistical analysis, Particles, Calibration

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SPIE Journal Paper | 1 July 2010 Open Access

Fiber-optic multiphoton flow cytometry in whole blood and in vivo

Yu-Chung Chang, Jing Yong Ye, Thommey Thomas, Zhengyi Cao, Alina Kotlyar, Eric Tkaczyk, James Baker, Theodore Norris

JBO, Vol. 15, Issue 04, 047004, (July 2010) https://doi.org/10.1117/12.10.1117/1.3463481

KEYWORDS: Blood, In vivo imaging, Green fluorescent protein, Luminescence, Flow cytometry, Fiber optics, Photon counting, Signal detection, Tumors, Absorption

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Proceedings Article | 26 February 2010 Paper

Real-time small molecule binding detection using a label-free photonic crystal biosensor

Yunbo Guo, Jing Yong Ye, Baohua Huang, Daniel McNerny, Thommey Thomas, James Baker, Theodore Norris

Proceedings Volume 7553, 755303 (2010) https://doi.org/10.1117/12.846011

KEYWORDS: Molecules, Sensors, Silica, Refractive index, Photonic crystals, Biosensors, Biological research, Modulation, Reflectivity, Molecular photonics

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Proceedings Article | 21 February 2009 Paper

Two-photon in vivo flow cytometry using a fiber probe

Yu-Chung Chang, Jing Yong Ye, Thommey Thomas, Zhengyi Cao, Alina Kotlyar, Eric Tkaczyk, James Baker, Theodore Norris

Proceedings Volume 7173, 71730I (2009) https://doi.org/10.1117/12.808436

KEYWORDS: Blood, Green fluorescent protein, In vivo imaging, Signal detection, Photon counting, Luminescence, Flow cytometry, Absorption, Scattering, Veins

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Proceedings Article | 16 February 2009 Paper

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry

Yunbo Guo, Jing Yong Ye, Charles Divin, Thommey Thomas, Andrzej Myc, Tommaso Bersano-Begey, James Baker, Theodore Norris

Proceedings Volume 7188, 71880B (2009) https://doi.org/10.1117/12.808369

KEYWORDS: Sensors, Refractive index, Reflectivity, Molecules, Photonic crystals, Absorption, Biological research, Dielectrics, Silica, Signal detection

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SPIE Journal Paper | 1 September 2008 Open Access

Errata: Quantitative two-photon flow cytometry—in

James Baker, Frank Zhong, Eric Tkaczyk, Thommey Thomas, Jing Yong Ye, Andrzej Myc, Anna Bielinska, Zhengyi Cao, Istvan Majoros, Balazs Keszler, Theodore Norris

JBO, Vol. 13, Issue 05, 059801, (September 2008) https://doi.org/10.1117/12.10.1117/1.2993165

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SPIE Journal Paper | 1 July 2008 Open Access

Extended cavity laser enhanced two-photon flow cytometry

Eric Tkaczyk, Alan Tkaczyk, Steve Katnik, Jing Ye, Kathryn Luker, Gary Luker, Andrzej Myc, James Baker, Jr., Theodore Norris

JBO, Vol. 13, Issue 04, 041319, (July 2008) https://doi.org/10.1117/12.10.1117/1.2967983

KEYWORDS: Green fluorescent protein, Blood, Signal detection, Flow cytometry, Capillaries, In vivo imaging, Optical spheres, Tumors, Luminescence, Mirrors

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SPIE Journal Paper | 1 May 2008 Open Access

Quantitative two-photon flow cytometry—in vitro and in vivo

Cheng Zhong, Eric Tkaczyk, Thommey Thomas, Jing Ye, Andrzej Myc, Anna Bielinska, Zhengyi Cao, Istvan Majoros, Balazs Keszler, James Baker, Theodore Norris

JBO, Vol. 13, Issue 03, 034008, (May 2008) https://doi.org/10.1117/12.10.1117/1.2931077

KEYWORDS: Luminescence, Flow cytometry, In vivo imaging, In vitro testing, Blood, Blood vessels, Particles, Femtosecond phenomena, Ear, Capillaries

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SPIE Journal Paper | 1 January 2008 Open Access

Investigation of tumor cell targeting of a dendrimer nanoparticle using a double-clad optical fiber probe

Thommey Thomas, Jing Ye, Yu-Chung Chang, Alina Kotlyar, Zhengyi Cao, Istvan Majoros, Theodore Norris, James Baker

JBO, Vol. 13, Issue 01, 014024, (January 2008) https://doi.org/10.1117/12.10.1117/1.2870105

KEYWORDS: Single mode fibers, Tumors, Luminescence, Dendrimers, Nanoparticles, Tissues, Optical fibers, Magnesium, Light scattering, Target detection

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Proceedings Article | 18 July 2007 Paper

Two-photon, two-color in vivo flow cytometry to noninvasively monitor multiple circulating cell lines

Eric Tkaczyk, Cheng Frank Zhong, Jing Yong Ye, Steve Katnik, Andrzej Myc, Thommey Thomas, Kathryn Luker, Gary Luker, James Baker, Theodore Norris

Proceedings Volume 6631, 66310T (2007) https://doi.org/10.1117/12.729490

KEYWORDS: Flow cytometry, In vivo imaging, Blood, Luminescence, Signal detection, Near infrared, Fluorescent proteins, Quantum dots, Green fluorescent protein, Breast cancer

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Proceedings Article | 13 February 2007 Paper

Metal/dendrimer nanocomposites for enhanced optical breakdown: acoustic characterization and initial targeted cell uptake study

Christine Tse, Wojciech Lesniak, Lajos P. Balogh, Jing Yong Ye, Matthew O'Donnell

Proceedings Volume 6449, 64490C (2007) https://doi.org/10.1117/12.698780

KEYWORDS: Silver, Nanocomposites, Metals, Acoustics, Luminescence, Dendrimers, Laser damage threshold, Backscatter, Particles, Confocal microscopy

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Metal/dendrimer nanocomposites (DNCs) uniquely combine the properties of metallic clusters and the biofriendly polymer host in a nanosized hybrid particle. DNCs can biochemically target tissues and locally reduce femtosecond optical breakdown thresholds, making highly precise and selective photodisruption possible. In this study, we have used high-frequency acoustic monitoring of bubble production dynamics to investigate how DNC properties, solution concentration, and optical parameters affect threshold reduction, actual waiting time, and mechanical characteristics of breakdown. Breakdown is defined here as bubble production with an onset of less than 20 seconds after laser exposure. DNC properties varied include metal content (silver, gold) and terminal group (amino-NH₂, glycidol-OH, and carboxyl- COOH) which determine pH values. Results indicate that DNC metal content markedly influences solution threshold reduction, while DNC terminal group (and thus net surface charge) and solution concentration influence the details of breakdown at these reduced threshold fluences. {Ag(0)} DNCs reduce breakdown threshold fluence 1-2 orders of magnitude more than {Au(0)} DNCs. Furthermore, concentrated DNC solutions and DNCs carrying a net negative charge (carboxyl terminal groups) increase bubble production up to four times and shorten waiting time for breakdown from seconds to milliseconds. Increasing laser fluence for a given DNC solution concentration also shortens breakdown waiting time. Lastly, utilizing the fluorescence properties of silver nanocomposites, we use confocal microscopy to examine KB cell uptake of folate targeted silver DNCs. Cells incubated with folate targeted silver DNCs exhibit a measurable increase of intracellular fluorescence compared to control cells (no DNC incubation). However, while we observe a threshold reduction in KB cells incubated with 500nM folate-targeted DNC solution, there is no threshold reduction in cells incubated with 50nM folate-targeted DNC solution. This suggests that a specific minimum DNC concentration may be required for localized reduced-threshold breakdown to occur.

Proceedings Article | 7 March 2006 Paper

Subsurface photodisruption in pig skin as monitored by high-frequency ultrasound

Christine Tse, Marwa Zohdy, Jing Yong Ye, Matthew O'Donnell

Proceedings Volume 6086, 60861U (2006) https://doi.org/10.1117/12.645327

KEYWORDS: Skin, Tissues, Tissue optics, Scattering, Objectives, Femtosecond phenomena, Light scattering, Ultrasonography, Laser scattering, Ultrasonics

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Proceedings Article | 28 February 2006 Paper

Tissue distribution and real-time fluorescence measurement of a tumor-targeted nanodevice by a two photon optical fiber fluorescence probe

Thommey Thomas, Jing Yong Ye, Chu-Sheng Yang, Monthiri Myaing, Istvan Majoros, Alina Kotlyar, Zhengyi Cao, Theodore Norris, James Baker

Proceedings Volume 6095, 60950Q (2006) https://doi.org/10.1117/12.645084

KEYWORDS: Tumors, Luminescence, Tissues, Nanostructures, Optical fibers, Tissue optics, Liver, Nanoparticles, Solids, Optical filters

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Proceedings Article | 23 February 2006 Paper

Increasing two-photon fluorescence signals by coherent control

Eric Tkaczyk, Augustin Mignot, Jing Yong Ye, Istvan Majoros, James Baker, Theodore Norris

Proceedings Volume 6089, 608910 (2006) https://doi.org/10.1117/12.644979

KEYWORDS: Second-harmonic generation, Luminescence, Genetic algorithms, Rhodamine, Oscillators, Chlorine, Crystal optics, Optical filters, Control systems, Molecules

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Proceedings Article | 25 April 2005 Paper

Optical and acoustical monitoring of femtosecond laser-induced intracellular contrast agents: initial cell culture studies

Marwa Zohdy, Christine Tse, Jing Yong Ye, Lajos Balogh, Theodore Norris, Matthew O'Donnell

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.589687

KEYWORDS: Acoustics, Nondestructive evaluation, Femtosecond phenomena, Optical microscopy, Transducers, Target detection, Laser optics, Pulsed laser operation, Camera shutters, Microscopy

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Proceedings Article | 30 March 2005 Paper

Two-photon flow cytometry

Cheng Zhong, Jing Yong Ye, Andrzej Myc, Thommey Thomas, Anna Bielinska, James Baker, Theodore Norris

Proceedings Volume 5700, (2005) https://doi.org/10.1117/12.589620

KEYWORDS: Luminescence, Optical spheres, Flow cytometry, Capillaries, Dendrimers, Computer simulations, Near infrared, Particles, Microfluidics, Femtosecond phenomena

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Proceedings Article | 30 March 2005 Paper

Development of a double-clad photonic-crystal-fiber-based scanning microscope

Jing Yong Ye, Mon Thiri Myaing, Thommey Thomas, Istvan Majoros, Alina Koltyar, James Baker, William Wadsworth, Geraud Bouwmans, Jonathan Knight, Philip Russell, Theodore Norris

Proceedings Volume 5700, (2005) https://doi.org/10.1117/12.589344

KEYWORDS: Microscopes, Luminescence, Confocal microscopy, GRIN lenses, Single mode fibers, Fiber lasers, Cladding, Laser scanners, Objectives, Dendrimers

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Proceedings Article | 10 June 2004 Paper

Two-photon fluorescence biosensing with conventional and photonic crystal fibers

Mon Thiri Myaing, Jing Yong Ye, Theodore Norris, Thommey Thomas, James Baker, William Wadsworth, Geraud Bouwmans, Jonathan Knight, Philip Russell

Proceedings Volume 5317, (2004) https://doi.org/10.1117/12.529394

KEYWORDS: Luminescence, Tumors, In vivo imaging, Dendrimers, Single mode fibers, Photonic crystal fibers, Biosensing, Optical fibers, Tissues, Flow cytometry

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Proceedings Article | 28 April 2004 Paper

Monitoring LIOB-induced bubble characteristics in gelatin using high-frequency ultrasound

Christine Tse, Marwa Zohdy, Jing Yong Ye, Theodore Norris, Lajos Balogh, Kyle Hollman, Matthew O'Donnell

Proceedings Volume 5373, (2004) https://doi.org/10.1117/12.534092

KEYWORDS: Pulsed laser operation, Backscatter, Acoustic emission, Ultrasonography, Laser stabilization, Laser optics, Laser tissue interaction, Tissue optics, Laser damage threshold, Cavitation

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Showing 5 of 38 publications

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