Dr. Kristie S. Johnson Profile

Dr. Kristie S. Johnson

Research Fellow at Univ College London

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Publications (6)

SPIE Journal Paper | 1 July 2010 Open Access

Scanning elastic scattering spectroscopy detects metastatic breast cancer in sentinel lymph nodes

Martin Austwick, Benjamin Clark, Charles Mosse, Kristie Johnson, D. Wayne Chicken, Santosh Somasundaram, Katherine Calabro, Ying Zhu, Mary Falzon, Gabrijela Kocjan, Thomas Fearn, Stephen Bown, Irving Bigio, Mohammed Keshtgar

JBO, Vol. 15, Issue 04, 047001, (July 2010) https://doi.org/10.1117/12.10.1117/1.3463005

KEYWORDS: Lymphatic system, Cancer, Scattering, Tissue optics, Breast cancer, Spectroscopy, Tumors, Tissues, Statistical analysis, Fiber optics

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Proceedings Article | 8 October 2005 Paper

In-vivo detection of pre-cancerous changes in Barrett's esophagus using elastic scattering spectroscopy (ESS)

Benjamin Clark, Kristie Johnson, Gary Mackenzie, Marco Novelli, Chelliah Selvasekar, Sally Thorpe, Stephen Bown, Laurence Lovat, Irving Bigio

Proceedings Volume 5862, 58620B (2005) https://doi.org/10.1117/12.633014

KEYWORDS: Tissue optics, Scattering, Biopsy, Esophagus, Spectroscopy, Raman scattering, Diagnostics, Tissues, Cancer, Raman spectroscopy

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Proceedings Article | 8 October 2005 Paper

Elastic scattering spectroscopy for detection of sentinel lymph node metastases in breast carcinoma

D. Chicken, A. Lee, K. Johnson, B. Clarke, M. Falzon, I. Bigio, S. Bown, M. Keshtgar

Proceedings Volume 5862, 58620C (2005) https://doi.org/10.1117/12.633015

KEYWORDS: Lymphatic system, Breast cancer, Spectroscopy, Breast, Scattering, Surgery, Biopsy, Tissue optics, Diagnostics, Statistical analysis

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SPIE Journal Paper | 1 November 2004 Open Access

Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast

Kristie Johnson, Dennis Chicken, David Pickard, Andrew Lee, Gavin Briggs, Mary Falzon, Irving Bigio, Mohammed Keshtgar, Stephen Bown

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1802191

KEYWORDS: Cancer, Lymphatic system, Spectroscopy, Scattering, Tissue optics, Cell biology, Breast cancer, Tissues, Diagnostics, Lamps

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Proceedings Article | 8 October 2003 Paper

Elastic scattering spectroscopy in the diagnosis of pigmented lesions: comparison with clinical and histopathological diagnosis

J. Scarisbrick, C. Pickard, Andrew Lee, Gavin Briggs, Kristie Johnson, Stephen Bown, Marco Novelli, M. Keshtgar, Irving Bigio, R. Yu

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.501181

KEYWORDS: Melanoma, Scattering, Diagnostics, Biopsy, Tissues, Light scattering, Spectroscopy, Skin, Absorption, Reflectivity

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Successful management of malignant melanoma depends on early detection and diagnostic accuracy. However studies have found a diagnostic accuracy of malignant melanoma amongst dermatologists of only 80% compared with histological diagnosis, results are generally poorer with family practitioners and dermatology trainees. Elastic scattering spectroscopy (ESS) is a non-invasive procedure that utilises elastically scattered light. A related technique, reflectance spectrometry, may discriminate between benign and malignant pigmented lesions in vivo. Objectives: We have therefore assessed an ESS biopsy system in the diagnosis of melanocytic lesions in vivo and compared the results to both clinical and histopathological diagnosis. Patients/Methods: One hundred melanocytic lesions from 77 patients attending our pigmented lesion clinic between 1999 and 2001 or seen at our Melanoma Day were examined clinically and divided into benign, dysplastic or malignant lesions. ESS spectra were acquired at several points from each lesion and adjacent normal skin. Lesions were then excised and sent for histological examination. Results: Lesions were histologically classified as 12 malignant melanoma (3 in-situ), 14 dysplastic naevi and 57 benign naevi (a further 17 clinically benign naevi were included which were not selected for excision). Clinical examination had a sensitivity of 75% and specificity of 91% for detection of malignant melanoma from other melanocytic lesions and overall diagnostic accuracy of differentiating melanocytic lesions of 71%. ESS spectral diagnosis classified by linear discriminant analysis indicated a sensitivity of 84% and specificity of 65% for detection of malignant melanoma from other melanocytic lesions. However the ESS spectral diagnosis included several readings per lesion and clinically this is not relevant. Therefore an ESS per lesional diagnosis was taken as the most aggressive diagnosis. This had a sensitivity of 100% and specificity of 75% for detection of malignant melanoma from other melanocytic lesions and overall diagnostic accuracy of differentiating melanocytic lesions of 69%. Discussion: These data suggest that ESS may be capable of differentiating malignant melanoma, dysplastic and benign naevi with a high sensitivity and provide adjuvant information to clinical examination by a dermatologist, which could be useful in the triage of melanocytic lesions.

Proceedings Article | 6 October 2003 Paper

Influence of temperature-dependent excited state absorption on a broadly tunable UV Ce:LiLuF laser

Kristie Johnson, David Coutts

Proceedings Volume 5137, (2003) https://doi.org/10.1117/12.517869

KEYWORDS: Absorption, Crystals, Polarization, Ultraviolet radiation, Tunable lasers, Solid state lasers, Laser crystals, Temperature metrology, Luminescence, Cerium

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