Fast and non-invasive screening test based on electrochemical detection of structural proteins of SARS-CoV-2 was developed. The measurement being the basis of the test is carried out in a standard three-electrode system, in which the working electrode is covered by bioreceptors immobilized on its surface by durable covalent bonding, ensuring specificity of the detection of desired analyte present in the sample. The carried out measurements allowed for detection of given protein of SARS-CoV-2 in standardized buffered samples and in samples containing virus-like particles. The estimated detection limit of the biosensor does not exceed 10^5 copies of the virus per milliliter.
We present a fibre optic biosensor for SARS-CoV-2 detection based on the lossy-mode-resonance (LMR) [6] effect, generated in a single-mode fibre with a thinned cladding and coated by thin-film dielectric with appropriately selected optical properties and thickness. The detection of selected viral structural proteins in the tested sample is ensured by specific bioreceptors. As a result of the interaction with the SARS-CoV-2 antigen, optical response in the short-wave-IR range is observed, and the detection limit does not exceed 1.3*10^2 copies/ml, when converted to the viral load concentration - sufficiently for virus detection even in the first days after infection.
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