Ms. Maria V. Klementeva Profile

Maria V. Klementeva

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Proceedings Article | 3 June 2019 Paper

Effect of ethanol on the transport of methylene blue through the rat skin ex vivo

Elizaveta Basko, Maria Klementeva, Alexey Bashkatov, Valery Tuchin, Elina Genina

Proceedings Volume 11065, 1106509 (2019) https://doi.org/10.1117/12.2524460

KEYWORDS: Skin, Diffusion, Bioalcohols, Absorbance, Tissues, Absorption, Optical phantoms, Molecules, Reflectivity, Ocean optics

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The main goal of the study is to investigate the effect of ethanol aqueous solutions with volume concentrations 30, 40, and 50% on the transport of Methylene Blue (MB) in rat skin ex vivo. The concentration dependences of MB absorbance in optical phantoms mimicking skin optical properties were measured. It has been obtained, for skin-like optical phantoms with low MB concentration (less than 0.025 mg/mL) the concentration dependence of MB absorption coefficient can be taken as linear in a first approximation. The study has shown that the diffusion rate grows with the increase of ethanol concentration in the solutions. The rate is 1.6 folds higher for 50%-ethanol solution of MB than when aqueous solution of MB is used. Effective diffusion coefficients of MB in skin samples have been evaluated as (3.34±0.07)×10^-6cm²/sec, (3.04±0.07)×10^-6 cm²/sec, (2.59±0.07)×10^-6 cm² /sec, and (1.85±0.06)×10^-7 cm²/sec for 50%, 40%, 30% ethanol solutions and aqueous solution, respectively. The characteristic time has the following values: 24.6±4.4 min, 40.1±3.2 min, 46.8±2.7 min, and 79.4±11.9 min for 50%, 40%, 30% aqueous ethanol solutions and aqueous solution, respectively.

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