Valery V. Tuchin is a corresponding Member of the Russian Academy of Sciences, Professor, Head of the Department of Optics and Biophotonics and Director of the Science Medical Center of the Saratov State University. He is also the Head of the Laboratory for Laser Diagnostics of Technical and Living Systems at the Institute of Precision Mechanics and Control of the RAS, the supervisor of the Interdisciplinary Laboratory of Biophotonics at the National Research Tomsk State University and the Femtomedicine Laboratory of the ITMO University.
His research and educational interests include biophotonics, biomedical optics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics, in all this fields he did pioneering contributions which are summarized in his first-class monographs, textbooks and inventions.
He is a member of SPIE, OPTICA and IEEE, Visiting Professor at HUST (Wuhan) and Tianjin Universities in China, and Adjunct Professor at the University of Limerick (Ireland) and the National University of Ireland (Galway).
Professor Tuchin is a Fellow of SPIE and OPTICA, for his outstanding input in the development of biophotonics and biomedical optics he was awarded Honored Scientist of the Russian Federation, Honored Professor of SSU, Honored Professor of Finland (FiDiPro), SPIE educational award (2007), Chime Bell award of Hubei province (China), Joseph Goodman (OPTICA/SPIE) award for Outstanding Monograph (2015), Michael Feld (OPTICA) award for Pioneering Research in Biophotonics (2019), the Medal of the D.S. Rozhdestvensky Optical Society (2018) and the A.M. Prokhorov medal of the Academy of Engineering Sciences named after A.M. Prokhorov (2021).
During his carrier, he demonstrated a publication record, being the author of more than 1000 articles (Web of Science), 30 monographs and textbooks, more than 60 patents. His works has been cited over 35,000 times, and his Google Scholar h-index is 83.
His research and educational interests include biophotonics, biomedical optics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics, in all this fields he did pioneering contributions which are summarized in his first-class monographs, textbooks and inventions.
He is a member of SPIE, OPTICA and IEEE, Visiting Professor at HUST (Wuhan) and Tianjin Universities in China, and Adjunct Professor at the University of Limerick (Ireland) and the National University of Ireland (Galway).
Professor Tuchin is a Fellow of SPIE and OPTICA, for his outstanding input in the development of biophotonics and biomedical optics he was awarded Honored Scientist of the Russian Federation, Honored Professor of SSU, Honored Professor of Finland (FiDiPro), SPIE educational award (2007), Chime Bell award of Hubei province (China), Joseph Goodman (OPTICA/SPIE) award for Outstanding Monograph (2015), Michael Feld (OPTICA) award for Pioneering Research in Biophotonics (2019), the Medal of the D.S. Rozhdestvensky Optical Society (2018) and the A.M. Prokhorov medal of the Academy of Engineering Sciences named after A.M. Prokhorov (2021).
During his carrier, he demonstrated a publication record, being the author of more than 1000 articles (Web of Science), 30 monographs and textbooks, more than 60 patents. His works has been cited over 35,000 times, and his Google Scholar h-index is 83.
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Optical coherence tomography of healthy and malignant tissues: physically reasonable differentiation
Selection of optimal hyperosmotic agent for tissue immersion optical clearing in the terahertz range
Sapphire capillary needles fabricated by edge-defined film-fed growth (EFG) technique hold strong potential in laser thermotherapy and photodynamic therapy, thanks to the advanced physical properties of sapphire. These needles feature an as-grown optical quality, their length is tens of centimeters, and they contain internal capillary channels, with open or closed ends. They can serve as optically transparent bearing elements with optical fibers introduced into their capillary channels in order to deliver laser radiation to biological tissues for therapeutic and, in some cases, diagnostic purposes. A potential advantage of the EFG-grown sapphire needles is associated with an ability to form the tip of a needle with complex geometry, either as-grown or mechanically treated, aimed at controlling the output radiation pattern. In order to examine a potential of the radiation pattern shaping, we present a set of fabricated sapphire needles with different tips. We studied the radiation patterns formed at the output of these needles using a He–Ne laser as a light source, and used intralipid-based tissue phantoms to proof the concept experimentally and the Monte-Carlo modeling to proof it numerically. The observed results demonstrate a good agreement between the numerical and experimental data and reveal an ability to control within wide limits the direction of tissue exposure to light and the amount of exposed tissue by managing the sapphire needle tip geometry.
This work is very important for many biomedical applications and bioengineering such as magnetic resonance imaging (MRI), magnetic drug delivery and targeting, magnetic separation and hyperthermic treatments.
In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides
The investigated samples were cutaneous tumours ex vivo, obtained after surgical removal and kept in a formalin solution and histological sections from biopsy tissue samples, which were routinely processed for histological analysis. Comparative spectral data for benign, dysplastic nevi and pigmented malignant melanoma lesions, as well as for nonmelanoma skin tumour – basal cell carcinoma, squamous cell carcinoma and benign non-melanin pigmented pathologies – heamangioma and seboreic veruca are presented in the current report.
Fluorescence spectra obtained reveal statistically significant differences between the different benign, dysplastic and malignant lesions by the level of emission intensity, as well by spectral shape, which are fingerprints applicable for differentiation algorithms. In reflectance and absorption modes the most significant differences are related to the influence of skin pigments – melanin and hemoglobin, less pronounced is the influence of structural proteins, such as collagen and keratin. Transmission spectroscopy mode gives complementary optical properties information about the tissue samples investigated to that one of reflectance and absorption spectroscopy.
Here, we present the model dependent on the data of our optical phantoms fabricated and measured in our previous preliminary study. The ambiguity between the modeling and the thermal measurements depend on lack of accurate knowledge of material's thermal properties and some exact parameters of the laser beam. Those parameters were varied in the simulation, to provide an overview of possible parameters' ranges and the magnitude of thermal response.
Stress plays provoking role in hypertension-related stroke: injuries of blood-brain barrier function
Materials and methods: Fresh porcine vocal folds were excised and applied a biocompatible OC agent (75% glycerol). Collimated transmittance was monitored. The tissue was optically cleared and put under the microscope for ablation threshold measurements at different depths.
Results: The time after which the tissue was optically cleared was roughly two hours. Fitting the threshold measurements to an exponential decay graph indicated that the scattering length of the tissue increased to 83±16 μm, which is more than doubling the known scattering length for normal tissue.
Conclusion: Optical clearing with Glycerol increases the tissue scattering length and therefore reduces the energy for ablation and increases the maximal ablation depth. This technique can potentially improve clinical microsurgery.
Monitoring of temperature-mediated adipose tissue phase transitions by refractive-index measurements
Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera
Two channel laser speckle instrument for biological microflow localization and velocity measurements
Computer simulation of light propagation in a multilayer biological tissue by the Monte Carlo method
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This course presents structural and optical models of tissues with basic single and multiple scattering, with ordered and randomly distributed scatterers. Coherent, spatially-modulated, and polarized light propagation in random and quasi-ordered tissue structures will be considered. It will be shown that tissue reflection and transmission, as well as scattered intensity and polarization can be effectively controlled by changes of its structure and refractive index of tissue components. Mechanisms of optical clearing (OC) at optical immersion of turbid tissues will be analyzed. Matching of refractive indices of scatterers and ground matter as a main mechanism of optical clearing at administration of optical clearing agents (OCA) for control of optical properties of tissues and blood will be discussed. Controllable tissue dehydration and rehydration and the usage of OC for optical and laser diagnostic and therapeutic purposes will be demonstrated. A considerable increase of penetration depth of probing light and improvement of image contrast will be shown. Optical monitoring of diffusion of endogenous and exogenous substances within a tissue also will be demonstrated. A considerable improvement of diagnostic methods and instruments, based on CW, time- and spatially-resolved light scattering, OCT, SHG, two-photon and confocal microscopy, speckle and polarization-sensitive techniques, will be shown for various medical applications. These applications include tissue and blood spectroscopy, OCT glucose sensing, optical imaging and laser surgery through the human skin, eye sclera, cerebral membrane, scull, bone, cartilage, tendon, body's interior tissues (vessel wall, esophagus, stomach), and vessel net.
This course presents structural and optical models of tissues with single and multiple scattering, with ordered and randomly distributed scatterers. Coherent, spatially modulated, and polarized light propagation in random and quasi-organized scattering media and tissues is considered. This course shows that reflection, transmission, light scattering, and state of polarization can be effectively controlled by changes of its structure, absorbing centers content, and refractive index of tissue components. Matching the refractive indices of scatterers and ground matter is one of discussed methods for control of optical properties of tissues. Diagnostic methods, various light scattering instruments, dynamic focused laser beam diffraction, speckle and low-coherence interferometry, polarimetry, and confocal microscopy are demonstrated for medical applications.
This course presents structural and optical models of tissues with single and multiple scattering, and with ordered and randomly distributed scatterers. Coherent and polarized light propagation in transparent and turbid tissues with birefringence and chirality will be described. Various diagnostic methods and imaging instruments based on CW, time- and spatially-resolved light scattering, speckle and partially-coherence interferometry, polarimetry, and microscopy, such as OCT, Scattering Matrix Meter, Laser Speckle Imager, etc., will be demonstrated for medical applications. Applications include testing and controlling of tissue and blood optical properties, analysis of structure and imaging of the human skin, eye tissues, body's interior tissues, monitoring of blood and lymph flow, and red blood cells sedimentation dynamics.
This course includes a curriculum and practical laboratory training for the study of tissue optics as a multi-disciplinary science by undergraduate and postgraduate students as well as by engineers and physicians. Structural and optical models of tissues with basic single and multiple scattering and with ordered and randomly distributed scatterers are discussed. Non-coherent, coherent, spatially-modulated, and polarized light propagation in random and quasi-organized tissues are considered. It is shown that reflection, transmission, light scattering, and state of polarization of the scattered light by a tissue can be effectively controlled by changes of its structure, absorbing centers content, and refractive index of tissue components. Various diagnostic methods and instruments based on CW, time-resolved, and spatially-resolved light scattering, speckle and low-coherence interferometry, and polarimetry will be demonstrated for medical applications.
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