Dr. Sabine Kling Profile

Dr. Sabine Kling

at ETH Zurich

SPIE Involvement:

Author

Publications (3)

Proceedings Article | 2 March 2022 Presentation

Ocular elastography by ambient pressure modulation

Sabine Kling

Proceedings Volume PC11962, PC119620Q (2022) https://doi.org/10.1117/12.2611385

KEYWORDS: Modulation, Elastography, Visualization, Tissues, Pathology, Optical coherence tomography, Eye, Diagnostics, Crystals, Cornea

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Proceedings Article | 3 December 2021 Paper

Corneal vibrography based on optical coherence tomography (OCT) B-scans

Sabine Kling

Proceedings Volume 11921, 1192109 (2021) https://doi.org/10.1117/12.2615457

KEYWORDS: Optical coherence tomography, Silicon, Phase measurement, In vivo imaging, Actuators, Wave propagation, Visualization, Tissues, Standards development, Phase shifts

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Proceedings Article | 26 February 2014 Paper

Corneal biomechanical properties from air-puff corneal deformation imaging

Susana Marcos, Sabine Kling, Nandor Bekesi, Carlos Dorronsoro

Proceedings Volume 8946, 894609 (2014) https://doi.org/10.1117/12.2047290

KEYWORDS: Cornea, In vivo imaging, Eye, Optical coherence tomography, Imaging systems, Finite element methods, Tissues, Tissue optics, Mercury, Ultraviolet radiation

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The combination of air-puff systems with real-time corneal imaging (i.e. Optical Coherence Tomography (OCT), or Scheimpflug) is a promising approach to assess the dynamic biomechanical properties of the corneal tissue in vivo. In this study we present an experimental system which, together with finite element modeling, allows measurements of corneal biomechanical properties from corneal deformation imaging, both ex vivo and in vivo. A spectral OCT instrument combined with an air puff from a non-contact tonometer in a non-collinear configuration was used to image the corneal deformation over full corneal cross-sections, as well as to obtain high speed measurements of the temporal deformation of the corneal apex. Quantitative analysis allows direct extraction of several deformation parameters, such as apex indentation across time, maximal indentation depth, temporal symmetry and peak distance at maximal deformation. The potential of the technique is demonstrated and compared to air-puff imaging with Scheimpflug. Measurements ex vivo were performed on 14 freshly enucleated porcine eyes and five human donor eyes. Measurements in vivo were performed on nine human eyes. Corneal deformation was studied as a function of Intraocular Pressure (IOP, 15-45 mmHg), dehydration, changes in corneal rigidity (produced by UV corneal cross-linking, CXL), and different boundary conditions (sclera, ocular muscles). Geometrical deformation parameters were used as input for inverse finite element simulation to retrieve the corneal dynamic elastic and viscoelastic parameters. Temporal and spatial deformation profiles were very sensitive to the IOP. CXL produced a significant reduction of the cornea indentation (1.41x), and a change in the temporal symmetry of the corneal deformation profile (1.65x), indicating a change in the viscoelastic properties with treatment. Combining air-puff with dynamic imaging and finite element modeling allows characterizing the corneal biomechanics in-vivo.

Conference Committee Involvement (2)

Emerging Technologies for Cell and Tissue Characterization

28 June 2023 | Munich, Germany

Emerging Technologies for Cell and Tissue Characterization

20 June 2021 | Online Only, Germany

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