Dr. Sergey G. Kuzmin Profile

Dr. Sergey G. Kuzmin

Chief Specialist at State Research Ctr NIOPIK

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Author

Publications (22)

Proceedings Article | 13 July 2007 Paper

Photodynamic therapy for treatment subretinal neovascularization

Sergey Avetisov, Maria Budzinskaja, Tatyana Kiseleva, Natalia Balatskaya, Irina Gurova, Viktor Loschenov, Sergey Shevchik, Sergey Kuzmin, Georgy Vorozhtsov

Proceedings Volume 6632, 663212 (2007) https://doi.org/10.1117/12.730392

KEYWORDS: Photodynamic therapy, Angiography, Eye, Visualization, Luminescence, Phase modulation, Ultrasonography, Curium, Refraction, Aluminum

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Proceedings Article | 13 July 2007 Paper

Results of photodynamic therapy in the combined treatment of choroidal metastasis

Vera Likhvantseva, Ekaterina Osipova, Mikhail Petrenko, Oksana Merzlyakova, Sergey Kuzmin, Georgy Vorozhtsov

Proceedings Volume 6632, 663214 (2007) https://doi.org/10.1117/12.730395

KEYWORDS: Photodynamic therapy, Tumors, Curium, Cancer, Computed tomography, Eye, Breast cancer, Pathology, Visualization, Radiotherapy

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Proceedings Article | 13 July 2007 Paper

5-aminolevulinic acid in aqueous gel: effective delivery system for ALA-based PDT

Nataliya Sakharova, Nataliya Kazachkina, Andrey Pankratov, Raisa Yakubovskaya, Nikolai Osikov, Vladimir Negrimovsky, Sergey Kuzmin, Evgeny Lukyanets, Georgy Vorozhtsov

Proceedings Volume 6632, 66320U (2007) https://doi.org/10.1117/12.728418

KEYWORDS: Tumors, Luminescence, Skin, Photodynamic therapy, Tissues, Fluorescence spectroscopy, Diagnostics, Polymers, Spectroscopy, Liver

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Proceedings Article | 13 July 2007 Paper

Adjuvant photodynamic therapy (PDT) with photosensitizer photosens for superficial bladder cancer: experimental investigations to treat prostate cancer by PDT with photosens

Oleg Apolikhin, Igor Chernishov, Andrey Sivkov, Denis Altunin, Sergey Kuzmin, Georgy Vorozhtsov

Proceedings Volume 6632, 663213 (2007) https://doi.org/10.1117/12.730393

KEYWORDS: Photodynamic therapy, Bladder, Bladder cancer, Prostate, Tumors, Prostate cancer, Cancer, Cystoscopy, Magnesium, Diffusers

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Proceedings Article | 28 February 2006 Paper

Cytotoxical products formation on the nanoparticles heated by the pulsed laser radiation

Boris Ya. Kogan, Andrey Titov, Victor Yu. Rakitin, Larisa Kvacheva, Sergey Kuzmin, Georgy Vorozhtsov

Proceedings Volume 6095, 60950S (2006) https://doi.org/10.1117/12.658131

KEYWORDS: Nanoparticles, Carbon, Radiation effects, Lymphoma, Pulsed laser operation, Cell death, Nd:YAG lasers, Cancer, Carbon monoxide, Chemical species

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Proceedings Article | 12 September 2003 Paper

Photodynamic therapy of acne vulgaris

Ekaterina Ershova, Lubov Karimova, Sergey Kharnas, Sergey Kuzmin, Victor Loschenov

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.499221

KEYWORDS: Photodynamic therapy, Luminescence, Diagnostics, Skin, Imaging systems, Semiconductor lasers, Laser therapeutics, CCD cameras, Spectrum analysis, Light sources

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Proceedings Article | 6 June 2002 Paper

ALA-containing transparent applicators on the basis of biodegradable polymers for photodynamic therapy of superficial malignancies

Gennadii Meerovich, Victor Loschenov, Victor Shental, Elena Vakoulovskaya, Anatoly Davydov, Gennady Khromov, Sergei Kuzmin, Eugeny Lukyanets, Iosif Tkach, Georgy Vorozhtsov

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469338

KEYWORDS: Photodynamic therapy, Polymers, Tissues, Tissue optics, Luminescence, Skin, Tumors, Helium neon lasers, Transparency, Absorption

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Proceedings Article | 29 December 1997 Paper

Improvement of cancer PDT using sulphophthalocyanine and sodium ascorbate

Oleg Kalija, Gennadii Meerovich, Nadezgda Torshina, Eugenia Kogan, Victor Loschenov, Eugeny Lukyanets, Boris Kogan, Alexander Butenin, Georgy Vorozhtsov, Sergei Kuzmin, Anna Volkova, Anna Posypanova

Proceedings Volume 3191, (1997) https://doi.org/10.1117/12.297800

KEYWORDS: Photodynamic therapy, Sodium, Cancer, Tumors, Oxygen, Cell death, Resistance

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Proceedings Article | 11 February 1997 Paper

Heartbeat detection using speckle statistics analysis

Sergey Kuzmin

Proceedings Volume 3053, (1997) https://doi.org/10.1117/12.266249

KEYWORDS: Scattering, Heart, Distortion, Laser scattering, Diffraction, Skin, Statistical analysis, Arteries, Speckle, Computer simulations

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Proceedings Article | 4 December 1996 Paper

Possibility of deep photodynamic action on tumor tissues using aluminium phtalocyanine

Gennadii Meerovich, Elena Vakoulovskaya, Victor Shental, Vitaliy Misin, Boris Kogan, Alexander Butenin, Sergei Kuzmin

Proceedings Volume 2924, (1996) https://doi.org/10.1117/12.260766

KEYWORDS: Tumors, Photodynamic therapy, Pulsed laser operation, Semiconductor lasers, CRTs, Tissues, Aluminum, Laser irradiation, Electron beams, Skin

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Proceedings Article | 4 December 1996 Paper

Photodynamic activity of a number of photosensitizers in vitro

Raisa Yakubovskaya, Victor Oganezov, Larisa Shytova, Tatyana Karmakova, Georgy Vorozhtsov, Sergei Kuzmin

Proceedings Volume 2924, (1996) https://doi.org/10.1117/12.260768

KEYWORDS: Toxicity, Rhodamine, Chlorine, Tumors, Molecules, Lung, In vitro testing, Photodynamic therapy, Curium, Actinium

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The comparative study of the photosensitizers with different chemical, spectral-luminescent and photophysical properties (phthalocyanines -- photosense, di- and trisulphonated zinc (II) phthalocyanines; chlorines -- chlorine p6, desvinyl-3- formyl-chlorine p6 and 3-desvinyl-3-acetyl-chlorine p6; xanthenes --rhodamine 123, rhodamine 6G-chloride, rhodamine 6G-acetate, rhodamine 6G-iodide; arylamines -- oxazinne perchlorate, oxazine-1 zinc salt, 9-diethylamino-5- ethylaminobenzophe-nothiazonium acetate, methylene blue) was performed. The cyto- and the phototoxicity of these compounds were studied on the cells of two human tumor cell lines (Raji B-cell lymphoma and A-549 lung adenocarcinoma) by MTT-test. It was shown that phthalocyanines and chlorines were not cytotoxic, whereas xanthenes and arylamines possessed dark toxicity. On the basis of the IC₅₀ (the substance concentration, which induced 50% inhibition of cell proliferation in the cell culture) the rows of phototoxicity of the compounds of various classes were set out: in phthalocyanines: ZnPcS₂ greater than Photosence greater than ZnPcS₃; in chlorines: 3dV-3F-Chl p6 greater than 3 dV-3Ac Chl p6 greater than Chl p6; in xanthenes: R6G- Ac greater than R6G-Cl greater than R6G-I greater than R 123; in arylamines: Meth B greater than or equal to 9-DE-B- Ac greater than Ox1-1/2ZnCl₄^2- very much greater than Ox1-ClO₄^-. Phototoxicity of the studied compounds depended on the nature of the substitutes and of the counter ions in photosensitizers molecules as well as on the concentration of the photosensitizer, on the light doses and on the regimes of irradiation. The fractionation of the light doses increased the efficiency of the phototoxic effect of the dyes on the tumor cells significantly. It was shown by the luminescent microscopy that the dynamics and the intensity of the accumulation of the rhodamines derivatives in lung adenocarcinoma cells depended on the nature of the counter ion in the photosensitizer molecule and correlated with their cyto- and pho-toxicity. Thus, photosense, di- and trisulphonated zinc phthalocyanines, 3- desvinyl-3-formyl-chlorine p6, rhodamine 6G-acetate and methylene blue turned out to be promising for their further study as photodynamic agents and efficient modifiers of chemoradiotherapy and of PDT.

Proceedings Article | 24 April 1996 Paper

Diffraction method of vocal chord oscillation sensing

Sergey Kuzmin, Valery Tuchin

Proceedings Volume 2676, (1996) https://doi.org/10.1117/12.238796

KEYWORDS: Skin, Scattering, Diffraction, Speckle, Laser scattering, Distortion, Light scattering, Gaussian beams, Computer simulations, Sensors

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Proceedings Article | 11 April 1996 Paper

Low-frequency biovibration detection using focused coherent fieldsdiffraction

Sergey Kuzmin

Proceedings Volume 2769, (1996) https://doi.org/10.1117/12.238013

KEYWORDS: Diffraction, Sensors, Skin, Scattering, Light scattering, Distortion, Computer simulations, Speckle, Signal detection, Biological research

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Proceedings Article | 9 February 1996 Paper

Speckle and speckle-interferometric methods in cardiodiagnostics

Sergey Kuzmin, Sergey Ulyanov, Valery Tuchin, Vladimir Ryabukho

Proceedings Volume 2732, (1996) https://doi.org/10.1117/12.231688

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Proceedings Article | 15 January 1996 Paper

Monitoring and analysis of skin vibration components using scattered coherent field dynamics

Sergey Kuzmin, Valery Tuchin

Proceedings Volume 2628, (1996) https://doi.org/10.1117/12.230009

KEYWORDS: Skin, Scattering, Laser scattering, Diffraction, Sensors, Light scattering, Biological research, Tissue optics, Computer simulations, Natural surfaces

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Proceedings Article | 10 November 1995 Paper

Investigation of statistical properties of dynamic speckles formed by focused Gaussian beam diffraction from a moving surface

Sergey Kuzmin, Sergey Ul'yanov

Proceedings Volume 2647, (1995) https://doi.org/10.1117/12.226679

KEYWORDS: Scattering, Gaussian beams, Diffraction, Laser scattering, Statistical analysis, Speckle, Computer simulations, Optical simulations, Light scattering, Speckle pattern

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Proceedings Article | 13 October 1995 Open Access

Practical works in the speckle optics for the subspecialties: physics of laser measurements and biomedical optics

Sergey Ulyanov, Sergey Kuzmin, Andrey Bednov, Valery Tuchin

Proceedings Volume 2525, (1995) https://doi.org/10.1117/12.224057

KEYWORDS: Speckle, Statistical analysis, Physics, Biomedical optics, Diffraction, Laser scattering, Scattering, Profilometers, Gaussian beams, Process modeling

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Proceedings Article | 13 October 1995 Open Access

Teaching of optical diffraction methods in biomedicine to undergraduates specializing in optics

Sergey Ulyanov, Valery Tuchin, Sergey Kuzmin, Andrey Bednov

Proceedings Volume 2525, (1995) https://doi.org/10.1117/12.224078

KEYWORDS: Diffraction, Gaussian beams, Biomedical optics, Lymphatic system, Scattering, Laser scattering, Diagnostics, Speckle, Skin, Profilometers

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Proceedings Article | 14 June 1995 Paper

Dynamic speckles formed by focused coherent field scattering from rough surfaces with non-Gaussian statistics

Sergey Kuzmin, Sergey Ulyanov

Proceedings Volume 2544, (1995) https://doi.org/10.1117/12.211872

KEYWORDS: Scattering, Laser scattering, Gaussian beams, Statistical analysis, Diffraction, Numerical modeling, Speckle, Light scattering, Computer simulations, Beam shaping

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Proceedings Article | 1 February 1995 Paper

Development of speckled speckles technique for cardiovibration measurements

Sergey Kuzmin, Sergey Ulyanov, Valery Tuchin

Proceedings Volume 2329, (1995) https://doi.org/10.1117/12.200876

KEYWORDS: Speckle, Gaussian beams, Scattering, Skin, Laser scattering, Light scattering, Statistical analysis, Diffraction, Biological research, Astatine

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Proceedings Article | 2 January 1995 Paper

Speckles application for cardiovibration measurements

Sergey Kuzmin, Sergey Ulyanov, Valery Tuchin

Proceedings Volume 2370, (1995) https://doi.org/10.1117/12.197468

KEYWORDS: Gaussian beams, Laser scattering, Scattering, Skin, Diffraction, Statistical analysis, Light scattering, Numerical modeling, Tissue optics, Life sciences

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Proceedings Article | 19 November 1993 Paper

Two-dimensional photodetector with the light-controlled area of photosensitivity

Andrei Kichaev, Peter Kasherininov, Sergey Kuzmin, Aleksey Klementiev, Ilya Yaroshetskii

Proceedings Volume 1985, (1993) https://doi.org/10.1117/12.162791

KEYWORDS: Photodetectors, Semiconductors, Data processing, Spatial resolution

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Showing 5 of 22 publications

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