Prof. Sixian You Profile

Prof. Sixian You

Assistant Professor at Massachusetts Institute of Technology

SPIE Involvement:

Conference Program Committee | Author

Publications (16)

Proceedings Article | 13 March 2024 Presentation + Paper

Leveraging uncertainty quantification in adaptive multiphoton microscopy acquisition

Cassandra Tong Ye, Jiashu Han, Kunzan Liu, Anastasios Angelopoulos, Linda Griffith, Kristina Monakhova, Sixian You

Proceedings Volume 12857, 1285707 (2024) https://doi.org/10.1117/12.2692749

KEYWORDS: Denoising, Multiphoton microscopy, Measurement uncertainty, Imaging systems, Deep learning, Biological imaging, Biological samples, Tissues, Statistical modeling, Fluorescence imaging

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Proceedings Article | 13 March 2024 Presentation

Towards richer and deeper microscopy: light manipulation by leveraging complex media

Sixian You

Proceedings Volume PC12851, PC1285101 (2024) https://doi.org/10.1117/12.3006070

KEYWORDS: Wavefronts

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Proceedings Article | 13 March 2024 Presentation

Multiplexed nonlinear label-free microscopy by excitation engineering

Sixian You

Proceedings Volume PC12855, PC1285516 (2024) https://doi.org/10.1117/12.3003233

KEYWORDS: Microscopy, Multiplexing, Nonlinear control, Tissues, Nonlinear optics, Multimode fibers, Light sources, Biological imaging, Windows, Two photon excitation microscopy

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Proceedings Article | 13 March 2024 Presentation

Tunable broadband fiber source for multiplexed nonlinear microscopy

Li-Yu Yu, Tong Qiu, Honghao Cao, Kunzan Liu, Sixian You

Proceedings Volume PC12853, PC1285308 (2024) https://doi.org/10.1117/12.3002906

KEYWORDS: Computer programming, Biological imaging, Signal detection, Multiphoton microscopy, Spectroscopy, Multiplexing, Digital micromirror devices, Tissues, Spectral resolution, Organisms

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Proceedings Article | 13 March 2024 Presentation

High-fidelity, high-speed wavefront shaping by leveraging complex media

Li-Yu Yu, Sixian You

Proceedings Volume PC12857, PC128570E (2024) https://doi.org/10.1117/12.3002657

KEYWORDS: Wavefronts, Spatial light modulators, Modulation, Digital micromirror devices, Speckle, Scattering media, Physics, Holography, Binary data

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Proceedings Article | 13 March 2024 Presentation

High-speed simultaneous label-free autofluorescence-multiharmonic (hSLAM) microscopy for multicellular dynamics

Kunzan Liu, Tong Qiu, Honghao Cao, Linda Griffith, Fan Wang, Sixian You

Proceedings Volume PC12854, PC1285406 (2024) https://doi.org/10.1117/12.3002856

KEYWORDS: Microscopy, Autofluorescence, Second harmonic generation, Feedback control, Biological imaging, Tissues, Third harmonic generation, Supercontinuum generation, Signal to noise ratio, Photonic crystal fibers

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Proceedings Article | 13 March 2024 Presentation

Biological discovery driven by AI-assisted label-free microscopy

Sixian You

Proceedings Volume PC12857, PC1285711 (2024) https://doi.org/10.1117/12.3011756

KEYWORDS: Hyperspectral imaging

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Proceedings Article | 15 March 2023 Presentation

Exploring multimode fiber sources for nonlinear microscopy and spectroscopy (Conference Presentation)

Sixian You

Proceedings Volume PC12384, PC123840C (2023) https://doi.org/10.1117/12.2645704

KEYWORDS: In vivo imaging, Optical microscopy, Microscopy, Signal generators, Optical imaging

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Proceedings Article | 5 March 2021 Presentation

label-free multimodal nonlinear imaging of the treatment response in pancreatic tumor patient-derived xenografts in mice

Jaena Park, Eric Chaney, Sixian You, Amro Abdelrahman, Jennifer Leiting, Jennifer Yonkus, Peter Groves, Jonathan Harrington, Darold Spillman, Issac Lynch, Marina Marjanovic, Haohua Tu, Colleen Bushell, Heidi Nelson, Mark Truty, Stephen Boppart

Proceedings Volume 11655, 116550J (2021) https://doi.org/10.1117/12.2576912

KEYWORDS: Tumors, Multimodal imaging, Microscopy, Pancreatic cancer, In vivo imaging, Supercontinuum sources, Photonic crystal fibers, Oncology, Harmonic generation, Convolution

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SPIE Journal Paper | 3 November 2020 Open Access

Simultaneous two-photon activation and imaging of neural activity based on spectral–temporal modulation of supercontinuum light

Yuan-Zhi Liu, Carlos Renteria, Connor Courtney, Baher Ibrahim, Sixian You, Eric Chaney, Ronit Barkalifa, Rishyashring Iyer, Mantas Zurauskas, Haohua Tu, Daniel Llano, Catherine Christian-Hinman, Stephen Boppart

NPh, Vol. 7, Issue 04, 045007, (November 2020) https://doi.org/10.1117/12.10.1117/1.NPh.7.4.045007

KEYWORDS: Calcium, Optogenetics, Brain, Image compression, Two photon imaging, Imaging systems, Supercontinuum sources, Neuroimaging, Luminescence, Light sources

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Proceedings Article | 9 March 2020 Presentation

Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)

Lingxiao Yang, Yi Sun, Darold Spillman, Sixian You, Stephen Boppart

Proceedings Volume 11234, 112340X (2020) https://doi.org/10.1117/12.2543216

KEYWORDS: Biopsy, Real time imaging, Multimodal imaging, Tissues, Tumors, Imaging systems, Fine needle aspiration, Error analysis, Luminescence, Harmonic generation

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Proceedings Article | 14 March 2018 Presentation

Intraoperative determination of tumor aggressiveness by real-time label-free nonlinear imaging and characterization of tumor-associated extracellular vesicles (Conference Presentation)

Yi Sun, Sixian You, Haohua Tu, Darold Spillman, Marina Marjanovic, Eric Chaney, George Liu, Anna Higham, Kimberly Cradock, Stephen Boppart

Proceedings Volume 10478, 1047805 (2018) https://doi.org/10.1117/12.2288818

KEYWORDS: Tumors, Breast cancer, Breast, Tissues, Imaging systems, Harmonic generation, Auto-fluorescence imaging, Real time imaging, Collagen, Visualization

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SPIE Journal Paper | 25 July 2017 Open Access

Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy

Sixian You, Yuan Liu, Zane Arp, Youbo Zhao, Eric Chaney, Marina Marjanovic, Stephen Boppart

JBO, Vol. 22, Issue 07, 070502, (July 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.7.070502

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Proceedings Article | 21 April 2017 Presentation

Photonic crystal fiber-generated coherent supercontinuum for fast stain-free histopathology and intraoperative multiphoton imaging (Conference Presentation)

Haohua Tu, Sixian You, Yi Sun, Darold Spillman, Partha Ray, George Liu, Stephen Boppart

Proceedings Volume 10094, 1009402 (2017) https://doi.org/10.1117/12.2252096

KEYWORDS: Breast cancer, Pollution control, Fiber lasers, Supercontinuum generation, Cancer, Surgery, Photonic crystals, Sapphire lasers, Biophotonic applications, Laser resonators

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Proceedings Article | 19 April 2017 Presentation

Intra-operative label-free multimodal multiphoton imaging of breast cancer margins and microenvironment (Conference Presentation)

Yi Sun, Sixian You, Haohua Tu, Darold Spillman, Marina Marjanovic, Eric Chaney, George Liu, Partha Ray, Anna Higham, Stephen Boppart

Proceedings Volume 10043, 1004307 (2017) https://doi.org/10.1117/12.2251057

KEYWORDS: Tumors, Imaging systems, Breast cancer, Multimodal imaging, Microscopes, Tissues, Breast, Mammography, Laser tissue interaction, Laser sources

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SPIE Journal Paper | 31 October 2016 Open Access

Rapid diagnosis and differentiation of microbial pathogens in otitis media with a combined Raman spectroscopy and low-coherence interferometry probe: toward in vivo implementation

Youbo Zhao, Guillermo Monroy, Sixian You, Ryan Shelton, Ryan Nolan, Haohua Tu, Eric Chaney, Stephen Boppart

JBO, Vol. 21, Issue 10, 107005, (October 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.107005

KEYWORDS: Raman spectroscopy, Ear, Pathogens, Remote sensing, In vivo imaging, Surface plasmons, Tissues, Microorganisms, Spectroscopy, Bacteria

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Showing 5 of 16 publications

Conference Committee Involvement (2)

Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences

25 January 2025 | San Francisco, California, United States

Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences

27 January 2024 | San Francisco, California, United States

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