Dr. Stephen L. Monfre Profile

Dr. Stephen L. Monfre

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Proceedings Article | 23 May 2002 Paper

Clinical results from a noninvasive blood glucose monitor

Thomas Blank, Timothy Ruchti, Alex Lorenz, Stephen Monfre, M. Makarewicz, Mutua Mattu, Kevin Hazen

Proceedings Volume 4624, (2002) https://doi.org/10.1117/12.468309

KEYWORDS: Calibration, Glucose, Tissue optics, Blood, Skin, Tissues, Data modeling, Near infrared, Mathematical modeling, Chemical analysis

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Non-invasive blood glucose monitoring has long been proposed as a means for advancing the management of diabetes through increased measurement and control. The use of a near-infrared, NIR, spectroscopy based methodology for noninvasive monitoring has been pursued by a number of groups. The accuracy of the NIR measurement technology is limited by challenges related to the instrumentation, the heterogeneity and time-variant nature of skin tissue, and the complexity of the calibration methodology. In this work, we discuss results from a clinical study that targeted the evaluation of individual calibrations for each subject based on a series of controlled calibration visits. While the customization of the calibrations to individuals was intended to reduce model complexity, the extensive requirements for each individual set of calibration data were difficult to achieve and required several days of measurement. Through the careful selection of a small subset of data from all samples collected on the 138 study participants in a previous study, we have developed a methodology for applying a single standard calibration to multiple persons. The standard calibrations have been applied to a plurality of individuals and shown to be persistent over periods greater than 24 weeks.

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