We report on our progress toward an ultrasensitive Raman-spectroscopic tool for nano-scale probing and imaging of biological objects such as viruses and cells. Our approach is based on laser spectroscopy aided by plasmonic nanoantennas, as in tip-enhanced Raman spectroscopy (TERS). An additional enhancement in sensitivity and speed can be obtained by employing the femtosecond adaptive spectroscopic technique (FAST) for coherent anti-Stokes Raman scattering (CARS). The combined approach will enable nondestructive label-free biosensing with molecular-level sensitivity and with spatial resolution down to a fraction of a nanometer.
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