Ms. Xi Yang Profile

Xi Yang

at Duke Univ

SPIE Involvement:

Author

Publications (9)

Proceedings Article | 13 March 2024 Presentation

Tomographic behavioral tracking of freely-moving model organisms with a hemispheric Fourier light field microscope

Kevin Zhou, Clare Cook, Archan Chakraborty, Joakim Jönsson, Kyung Chul Lee, Xi Yang, Shiqi Xu, Jennifer Bagwell, Donald Fox, Michel Bagnat, Roarke Horstmeyer

Proceedings Volume PC12848, PC128480M (2024) https://doi.org/10.1117/12.3000874

KEYWORDS: Organisms, Microscopes, Tomography, Algorithm development, 3D modeling, Detection and tracking algorithms, 3D tracking, 3D image processing, Reconstruction algorithms, Muscles

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Proceedings Article | 13 March 2024 Presentation

High-content multimodal in vivo imaging using a parallelized gigapixel scale microscope

Xi Yang, Aurélien Bègue, Mark Harfouche, Clare Cook, Kanghyun Kim, Kevin Zhou, Roarke Horstmeyer

Proceedings Volume PC12848, PC128480H (2024) https://doi.org/10.1117/12.3002079

KEYWORDS: Organisms, In vivo imaging, Microscopy, Neurological disorders, Biological imaging, Alzheimer's disease, Zoom lenses, Video, Parkinson disease, Motion models

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SPIE Journal Paper | 4 March 2024 Open Access

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

Shiqi Xu, Xi Yang, Paul Ritter, Xiang Dai, Kyung Chul Lee, Lucas Kreiss, Kevin Zhou, Kanghyun Kim, Amey Chaware, Jadee Neff, Carolyn Glass, Seung Ah Lee, Oliver Friedrich, Roarke Horstmeyer

AP, Vol. 6, Issue 02, 026004, (March 2024) https://doi.org/10.1117/12.10.1117/1.AP.6.2.026004

KEYWORDS: Muscles, Biological samples, Tissues, Tomography, Birefringence, Polarization, Image restoration, Light sources and illumination, Matrices, Biological imaging

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Proceedings Article | 11 August 2023 Presentation + Paper

High-throughput imaging across multiple spatial scales with the multi-camera array microscope (MCAM)

Lucas Kreiss, Kevin Zhou, Kanghyun Kim, Mark Harfouche, Shiqi Xu, Joakim Jönsson, Kyung Chul Lee, Clare Cook, Xi Yang, Paul Reamey, Veton Saliu, Gregor Horstmeyer, Roarke Horstmeyer

Proceedings Volume 12622, 126220S (2023) https://doi.org/10.1117/12.2675451

KEYWORDS: Cameras, Microscopes, Video, Image resolution, 3D image processing, Video microscopy, Stereoscopy, Lens arrays, Imaging systems

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Proceedings Article | 16 March 2023 Presentation

High-throughput tomographic fluorescence imaging with a synchronized camera array (Conference Presentation)

Kevin Zhou, Joakim Jönsson, Clare Cook, Kyung Chul Lee, Xi Yang, Shiqi Xu, Jennifer Bagwell, Archan Chakraborty, Donald Fox, Michel Bagnat, Roarke Horstmeyer

Proceedings Volume PC12390, PC123900C (2023) https://doi.org/10.1117/12.2649458

KEYWORDS: Tomography, Luminescence, Cameras, Organisms, 3D modeling, Objectives, Video, Signal attenuation, Reflectors, Reconstruction algorithms

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Proceedings Article | 12 September 2021 Presentation

Imaging anisotropy with vectorial Fourier ptychography

Shiqi Xu, Xiang Dai, Xi Yang, Kevin Zhou, Pavan Konda, Roarke Horstmeyer

Proceedings Volume 11875, 118750F (2021) https://doi.org/10.1117/12.2598999

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Microscopic imaging of anisotropic samples has many important applications in cytopathology. The endogenous contrast from the polarization properties of a specimen, such as its birefringence, provides valuable diagnostic information for several deadly diseases, including cardiac amyloidosis and squamous cell carcinoma, for example. In the past, polarized light microscopy (PLM) has been widely used as a diagnostic tool during the clinical review. However, in analogy with the standard microscope, the PLM typically has a restricted spatial-bandwidth product (SBP). As a consequence, one can either image a large area with low resolution or see the details of a very small area of the sample at the resolutions required for accurate analysis. To address the SBP issue of the PLM, we propose a computational microscopy method, termed vectorial Fourier ptychography, to illuminate the specimen with polarized light from different angles and detects different polarization states of the diffracted light. By illuminating a specimen with plane waves from different angles, our vectorial Fourier ptychography method effectively modulates the high-spatial-frequency components of the specimen into lower frequencies that can be detected by the optical system. With a Jones calculus-based forward model and a second-order phase retrieval method, we can reconstruct high-resolution, wide field-of-view(FOV) amplitude, phase, birefringence, retardance, and diattenuation of the specimen. To assess the reconstruction accuracy of our method, we imaged polystyrene beads submerged in immersion oils of different refractive index, as well as monosodium urate crystals. Further, To validate the diattenuation reconstruction accuracy, we reconstruct a USAF resolution test chart with a half blocked by a linear polarizer. These experiments confirm quantitatively accurate reconstruction results with a 1.25 um full-pitch resolution over a FOV of 6.6 x 4.4 mm^2, which is 5 times higher than the native (brightfield) resolution of the non-computational optical system. Finally, we demonstrate our technique by producing high SBP polarization images of several anisotropic biologic samples, includes collagen tissue, congo red stained cardiac tissue, and a bean root sample.

Proceedings Article | 5 March 2021 Presentation

Imaging decorrelation via deep learning and SPAD array detection

Shiqi Xu, Xi Yang, Wenhui Liu, Ruobing Qian, Pavan Chandra Konda, Roarke Horstmeyer

Proceedings Volume 11629, 116292A (2021) https://doi.org/10.1117/12.2578644

KEYWORDS: Detector arrays, Tissues, Digital micromirror devices, Tissue optics, Temporal resolution, Spectroscopy, Sensors, Scattering media, Natural surfaces, Monte Carlo methods

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Proceedings Article | 5 March 2021 Presentation

Snapshot gigapixel-scale imaging at high resolution using a micro-camera array microscope

Xi Yang, Pavan Chandra Konda, Jaehee Park, Mark Harfouche, Roarke Horstmeyer

Proceedings Volume 11622, 1162207 (2021) https://doi.org/10.1117/12.2577286

KEYWORDS: Image resolution, Microscopes, Objectives, Cameras, Lenses, Imaging systems, Image sensors, Image segmentation, Sensors, Sensor technology

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Proceedings Article | 10 March 2020 Presentation

Towards high-speed fourier ptychographic imaging using binary measurements on a SPAD camera (Conference Presentation)

Xi Yang, Pavan Chandra Konda, Roarke Horstmeyer

Proceedings Volume 11250, 1125014 (2020) https://doi.org/10.1117/12.2546824

KEYWORDS: Cameras, Binary data, High speed cameras, LIDAR, Fluorescence lifetime imaging, Reconstruction algorithms, Avalanche photodiodes, Single photon, Picosecond phenomena, High speed imaging

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Showing 5 of 9 publications

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