Prof. Guang-Hong Chen Profile

Prof. Guang-Hong Chen

Professor at Univ of Wisconsin in Madison SMPH

SPIE Involvement:

Author | Editor

Publications (145)

SPIE Journal Paper | 3 December 2024

Comparison of sequential multi-detector CT and cone-beam CT perfusion maps in 39 subjects with anterior circulation acute ischemic stroke due to a large vessel occlusion

John Garrett, Kelly Capel, Laura Eisenmenger, Azam Ahmed, David Niemann, Yinsheng Li, Ke Li, Dalton Griner, Sebastian Schafer, Charles Strother, Guang-Hong Chen, Beverly Aagaard-Kienitz

JMI, Vol. 11, Issue 06, 065502, (December 2024) https://doi.org/10.1117/12.10.1117/1.JMI.11.6.065502

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Proceedings Article | 3 April 2024 Presentation

Recycling scattered X-rays within edge-on Si photon counting detectors via Si-scintillator lamination

Christian De Caro, Guang-Hong Chen, Ke Li

Proceedings Volume 12925, 129250D (2024) https://doi.org/10.1117/12.3008619

KEYWORDS: Spatial resolution, Quantum detection, Silicon, X-rays, X-ray detectors, Scintillators, Photon counting, Signal detection, Photodiodes, Metals

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Proceedings Article | 3 April 2024 Presentation

Iodine map generation from single-kV contrast-enhanced CT using a conditional generative model

Ran Zhang, Yijing Wu, John Garrett, Ke Li, Meghan Lubner, Thomas Grist, Guang-Hong Chen

Proceedings Volume 12925, 1292509 (2024) https://doi.org/10.1117/12.3008641

KEYWORDS: Iodine, Data modeling, Computed tomography, Education and training, Scanners, Performance modeling, Diffusion, Biomedical applications, Statistical modeling, Medical imaging

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Proceedings Article | 3 April 2024 Presentation

Experimental methods to estimate the dead time of photon counting detectors

Linying Zhan, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 12925, 129250A (2024) https://doi.org/10.1117/12.3006560

KEYWORDS: Photon counting, Time correlated photon counting, Computed tomography, Time metrology, Systems modeling, Spatial resolution, Imaging spectroscopy, Image registration, Detector development

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Proceedings Article | 7 April 2023 Paper

K-edge photon counting CT imaging using a dual-bin photon counting detector and kV switching

Kevin Treb, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 12463, 124633I (2023) https://doi.org/10.1117/12.2654241

KEYWORDS: Gadolinium, Iodine, Switching, Photon counting, Signal to noise ratio, X-rays, Computed tomography, X-ray computed tomography, Spectral response, X-ray imaging

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Proceedings Article | 7 April 2023 Presentation + Paper

Addressing the challenge of CT number bias in low-dose photon counting CT without access to raw detector count data

Dalton Griner, Nikou Lei, Guang-Hong Chen, Ke Li

Proceedings Volume 12463, 124631N (2023) https://doi.org/10.1117/12.2654372

KEYWORDS: Bias correction, Computed tomography, Photon counting, Image restoration, Tomography, Medical image reconstruction, Statistical analysis, Histograms, Digital recording, Detector development

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Proceedings Article | 7 April 2023 Presentation + Paper

Empirical unbiased zero-count correction in photon counting CT

Daniel Bushe, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 12463, 124631P (2023) https://doi.org/10.1117/12.2650457

KEYWORDS: Bias correction, Computed tomography, Tunable filters, Spatial resolution, Iodine, Image restoration, Photon counting, Statistical analysis, Attenuation

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Proceedings Article | 7 April 2023 Poster + Paper

Reconstruction of local noise power spectrum from a single CT data acquisition

Chengzhu Zhang, Ke Li, Ran Zhang, Guang-Hong Chen

Proceedings Volume 12463, 124633U (2023) https://doi.org/10.1117/12.2654367

KEYWORDS: X-ray computed tomography, Data acquisition, Image restoration, Covariance, Imaging systems, Modulation transfer functions, Medical image reconstruction, X-rays

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Proceedings Article | 7 April 2023 Poster

Deep-QC: a quality-check framework for quantitative material estimation from single-kV CT data

Xin Tie, Yinsheng Li, Ran Zhang, Ke Li, Guanghong Chen

Proceedings Volume 12463, 1246340 (2023) https://doi.org/10.1117/12.2654515

KEYWORDS: Tomography, Reliability, Physics, Image analysis, Image acquisition, Human subjects, Functional analysis, Data acquisition, Error analysis, Neural networks

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Proceedings Article | 7 April 2023 Presentation

Scatter-to-primary ratio in photon counting CT

Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 12463, 1246306 (2023) https://doi.org/10.1117/12.2654253

KEYWORDS: X-ray computed tomography, Photon counting, Sensors, X-rays, X-ray detectors, Physics, New and emerging technologies, Monte Carlo methods, Data acquisition, Computed tomography

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Proceedings Article | 7 April 2023 Presentation

Intra-detector x-ray scatterings in edge-on irradiated silicon photon counting CT: how to harvest information from scattered photons

Ke Li, Christian De Caro, Ran Zhang, Guang-Hong Chen

Proceedings Volume 12463, 124630D (2023) https://doi.org/10.1117/12.2654227

KEYWORDS: Silicon, X-rays, Sensors, Scattering, Photon counting, X-ray detectors, Quantum information, Semiconductors, Semiconductor materials, Semiconducting wafers

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Proceedings Article | 4 April 2022 Poster + Paper

An analytical model of energy response function for CdTe-based photon counting detectors with inter-pixel communication for anti-coincidence corrections

Xu Ji, Mang Feng, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 12031, 120314N (2022) https://doi.org/10.1117/12.2611848

KEYWORDS: X ray detectors, Systems modeling, X-rays, Compton scattering, Sensors, Tellurium, Cadmium, Scattering, Photon counting

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Proceedings Article | 4 April 2022 Presentation

Quantitative lung perfusion blood volume maps using effective Z images learned from single-kV pulmonary CT angiography data

Ke Li, Yinsheng Li, Zhihua Qi, John Garrett, Thomas Grist, Guang-Hong Chen

Proceedings Volume PC12031, PC120310J (2022) https://doi.org/10.1117/12.2612593

KEYWORDS: Computed tomography, Lung, Iodine, Blood, Angiography, Nuclear medicine, Neural networks, Human subjects, Hemodynamics, Functional imaging

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Proceedings Article | 4 April 2022 Presentation

Deep-En-Chroma: mining the spectral fingerprints in single-kV CT acquisitions using energy integration detectors

Yinsheng Li, Xin Tie, Ke Li, John Garrett, Guang-Hong Chen

Proceedings Volume PC12031, PC120310I (2022) https://doi.org/10.1117/12.2611838

KEYWORDS: X-ray computed tomography, Sensors, Mining, X-rays, Imaging systems, Data acquisition, Tissues, Medicine, Medical imaging modalities, Human subjects

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Proceedings Article | 21 March 2022 Presentation

A multi-contrast chest x-ray radiography prototype with low-dose fast scanning-beam acquisition

Daniel Bushe, Xu Ji, Ran Zhang, Mang Feng, Kevin Treb, Guang-Hong Chen, Ke Li

Proceedings Volume PC12031, PC1203103 (2022) https://doi.org/10.1117/12.2612676

KEYWORDS: Chest imaging, Radiography, Imaging systems, Prototyping, Pulmonary disorders, Chronic obstructive pulmonary disease, X-rays, X-ray imaging, Standards development, Sensors

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Proceedings Article | 15 February 2021 Presentation + Paper

COVID-19 pneumonia diagnosis using chest x-ray radiograph and deep learning

Dalton Griner, Ran Zhang, Xin Tie, Chengzhu Zhang, John Garrett, Ke Li, Guang-Hong Chen

Proceedings Volume 11597, 1159706 (2021) https://doi.org/10.1117/12.2581972

KEYWORDS: Chest imaging, Radiography, X-rays, Polymers, Machine learning, Gold, Data modeling

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Proceedings Article | 15 February 2021 Presentation

Overcoming the "catastrophic forgetting" effect in transfer learning to achieve vendor independent performance for the COVID-19 pneumonia classification task using chest x-ray radiographs

Ran Zhang, Guang-Hong Chen

Proceedings Volume 11597, 115971R (2021) https://doi.org/10.1117/12.2581088

KEYWORDS: Data modeling, Chest imaging, Radiography, Performance modeling, Imaging systems, Neural networks, Image processing

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Proceedings Article | 15 February 2021 Presentation + Paper

Deep learning in image reconstruction: vulnerability under adversarial attacks and potential defense strategies

Chengzhu Zhang, Yinsheng Li, Guang-Hong Chen

Proceedings Volume 11595, 115951U (2021) https://doi.org/10.1117/12.2581369

KEYWORDS: Image restoration, Defense and security, Medical imaging applications, CT reconstruction, X-ray computed tomography, Neural networks, Data acquisition

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Proceedings Article | 15 February 2021 Presentation + Paper

DeepInterior: new pathway to address the interior tomographic reconstruction problem in CT via direct backprojecting divergent beam projection data

Chengzhu Zhang, Yinsheng Li, Ke Li, Guang-Hong Chen

Proceedings Volume 11595, 115951Q (2021) https://doi.org/10.1117/12.2581368

KEYWORDS: Tomography, Data acquisition, Visualization, Neural networks, Collimation

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Proceedings Article | 15 February 2021 Presentation + Paper

Generation of virtual non-contrast (VNC) image from dual energy CT scans using deep learning

Yinsheng Li, Ke Li, John Garrett, Guang-Hong Chen

Proceedings Volume 11595, 115951E (2021) https://doi.org/10.1117/12.2582006

KEYWORDS: Computed tomography, Dual energy imaging, Range imaging, Medical imaging applications, Machine learning

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Proceedings Article | 15 February 2021 Presentation

Photon counting CT in a C-arm interventional system: hardware development and artifact corrections

Xu Ji, Mang Feng, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 11595, 115950A (2021) https://doi.org/10.1117/12.2581087

KEYWORDS: Photon counting, Sensors, Calibration, Computed tomography, Imaging systems, Spatial resolution, Quantum efficiency, Model-based design, Head, Distortion

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Proceedings Article | 15 February 2021 Presentation

Single-kV multi-contrast x-ray imaging for gout detection and gout-pseudogout differentiation

Daniel Bushe, Ran Zhang, Xu Ji, Mang Feng, Guang-Hong Chen, Ke Li

Proceedings Volume 11595, 115951P (2021) https://doi.org/10.1117/12.2580972

KEYWORDS: X-ray imaging, Crystals, Imaging systems, Diagnostics, Crystallography, X-rays, Signal detection, Signal attenuation, Numerical simulations, Calcium

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Proceedings Article | 16 March 2020 Presentation + Paper

Impact of photon counting detector spectral distortion on virtual non-contrast CT imaging

Mang Feng, Xu Ji, Ran Zhang, Jessica Miller, Guang-Hong Chen, Ke Li

Proceedings Volume 11312, 113121J (2020) https://doi.org/10.1117/12.2549737

KEYWORDS: X-ray computed tomography, Distortion, Iodine, Photon counting, Sensors, Calcium, Computed tomography, X-rays, Signal attenuation, Blood

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Proceedings Article | 16 March 2020 Paper

Quantitative blood flow imaging with time-resolved C-arm cone-beam CT imaging

John Garrett, Yinsheng Li, Juan Montoya, Yijing Wu, Ke Li, Charles Strother, Guang-Hong Chen

Proceedings Volume 11312, 113123G (2020) https://doi.org/10.1117/12.2548516

KEYWORDS: Blood circulation, Data acquisition, Angiography, Computed tomography, Temporal resolution, Human subjects, Numerical simulations, Diagnostics, Imaging systems, Image enhancement

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Proceedings Article | 16 March 2020 Paper

Correction for cone beam CT image artifacts via a deep learning method

Dalton Griner, John Garrett, Yinsheng Li, Ke Li, Guang-Hong Chen

Proceedings Volume 11312, 113124H (2020) https://doi.org/10.1117/12.2549685

KEYWORDS: Computed tomography, Data acquisition, Image segmentation, Image quality, Image registration, Sensors, Image processing, Network architectures, Convolution, X-ray computed tomography

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Proceedings Article | 16 March 2020 Paper

Feasibility of achieving spectral CT imaging from a single KV acquisition and deep learning method

Yinsheng Li, Juan Pablo Cruz-Bastida, Ke Li, Daniel Bushe, Christopher François, Meghan Lubner, Guang-Hong Chen

Proceedings Volume 11312, 1131222 (2020) https://doi.org/10.1117/12.2549611

KEYWORDS: Computed tomography, X-ray computed tomography, X-rays, Data acquisition, Iodine, Sensors, X-ray imaging, Photons, Information fusion, Calcium

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Proceedings Article | 16 March 2020 Paper

High temporal resolution time-resolved C-arm cone-beam CT imaging using a multi-sweep data acquisition scheme

Yinsheng Li, John Garrett, Ke Li, Charles Strother, Guang-Hong Chen

Proceedings Volume 11312, 113121K (2020) https://doi.org/10.1117/12.2549602

KEYWORDS: Temporal resolution, Data acquisition, Angiography, Human subjects, Arteries, Image restoration, Numerical simulations, Tissues, In vivo imaging, Superposition

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Proceedings Article | 16 March 2020 Presentation + Paper

Deep learning enabled prior image constrained compressed sensing (DL-PICCS) reconstruction framework for sparse-view reconstruction

Chengzhu Zhang, Yinsheng Li, Guang-Hong Chen

Proceedings Volume 11312, 1131206 (2020) https://doi.org/10.1117/12.2549444

KEYWORDS: Image restoration, Computed tomography, Compressed sensing, Human subjects, Reconstruction algorithms, Neural networks, Abdomen, CT reconstruction, Liver, X-ray computed tomography

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Proceedings Article | 16 March 2020 Paper

Phase contrast CT enabled three-material decomposition in spectral CT imaging

Xu Ji, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 11312, 113121B (2020) https://doi.org/10.1117/12.2549014

KEYWORDS: X-ray computed tomography, Phase contrast, Dual energy imaging, X-rays, Computed tomography, Absorption

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Proceedings Article | 14 March 2019 Presentation

Patient-specific noise power spectrum measurement via generative adversarial networks (Conference Presentation)

Chengzhu Zhang, Daniel Gomez-Cardona, Yinsheng Li, Juan Montoya, Guang-hong Chen

Proceedings Volume 10948, 109480I (2019) https://doi.org/10.1117/12.2513207

KEYWORDS: Statistical methods

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Proceedings Article | 14 March 2019 Presentation

Volumetric scout CT images reconstructed from conventional two-view radiograph localizers using deep learning (Conference Presentation)

Juan Camilo Montoya, Chengzhu Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 10948, 1094825 (2019) https://doi.org/10.1117/12.2513133

KEYWORDS: Computed tomography, Radiography, Neural networks, CT reconstruction, 3D modeling, 3D metrology, Diagnostics, 3D image processing, 3D image reconstruction, 3D imaging standards

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Proceedings Article | 13 March 2019 Paper

Unbiased statistical image reconstruction in low-dose CT

John Hayes, Ran Zhang, Chengzhu Zhang, Daniel Gomez-Cardona, Guang-Hong Chen

Proceedings Volume 10948, 1094859 (2019) https://doi.org/10.1117/12.2512848

KEYWORDS: Computed tomography, X-ray computed tomography, Denoising, Statistical analysis, Medicine

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Proceedings Article | 7 March 2019 Presentation + Paper

Spectrum optimization in photon counting detector based iodine K-edge CT imaging

Mang Feng, Xu Ji, Kevin Treb, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 10948, 109481C (2019) https://doi.org/10.1117/12.2512893

KEYWORDS: Iodine, X-ray computed tomography, X-rays, X-ray imaging, Photon counting

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Proceedings Article | 7 March 2019 Paper

Quantitative low-dose CT: potential value of low signal correction methods

Juan Pablo Cruz-Bastida, Ran Zhang, Daniel Gomez-Cardona, Guang-Hong Chen

Proceedings Volume 10948, 1094830 (2019) https://doi.org/10.1117/12.2512889

KEYWORDS: X-ray computed tomography, Computed tomography, Image quality, Denoising, Photon counting, X-rays

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Proceedings Article | 7 March 2019 Presentation + Paper

Image reconstruction from fully-truncated and sparsely-sampled line integrals using iCT-Net

Yinsheng Li, Ke Li, Chengzhu Zhang, Juan Montoya, Guang-Hong Chen

Proceedings Volume 10948, 109480S (2019) https://doi.org/10.1117/12.2513088

KEYWORDS: Data acquisition, Image restoration, Image processing, Human subjects, Computed tomography, Data processing, X-ray computed tomography, Scanners, Lithium, Medical diagnostics

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Proceedings Article | 7 March 2019 Presentation + Paper

Human-compatible multi-contrast mammographic prototype system

Ran Zhang, Ke Li, John Garrett, Guang-Hong Chen

Proceedings Volume 10948, 109480X (2019) https://doi.org/10.1117/12.2513149

KEYWORDS: Imaging systems, Mammography, Breast imaging, Interferometers

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Proceedings Article | 1 March 2019 Presentation + Paper

An experimental method to correct drift-induced error in zero-frequency DQE measurement

Xu Ji, Mang Feng, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 10948, 109480H (2019) https://doi.org/10.1117/12.2512467

KEYWORDS: Signal to noise ratio, Imaging systems, Error analysis, Modulation transfer functions, Signal detection, Photons, Numerical simulations, X-ray imaging

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Proceedings Article | 1 March 2019 Presentation + Paper

Impact of the sensitivity factor on the signal-to-noise ratio in grating-based phase contrast imaging

Xu Ji, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 10948, 109481Q (2019) https://doi.org/10.1117/12.2512251

KEYWORDS: Signal to noise ratio, Statistical analysis, Phase contrast, Photons, Numerical simulations, Refraction, Phase shifts, Visibility, X-rays

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Proceedings Article | 1 March 2019 Presentation + Paper

Impacts of photon counting detector to cerebral CT angiography maximum intensity projection (MIP) images

Evan Harvey, Mang Feng, Xu Ji, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 10948, 109481Z (2019) https://doi.org/10.1117/12.2513205

KEYWORDS: Signal to noise ratio, Computed tomography, Arteries, Sensors, Photon counting, Angiography, Signal detection, X-ray computed tomography, Spatial resolution, Head

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Cerebral CT angiography (CTA) is widely used for the diagnosis of various cerebrovascular diseases, including strokes, vasculitis, aneurysms, and etc.2–4 For the diagnosis of ischemic strokes, the availability of high quality CTA images not only helps in identifying the presence/location of large vessel occlusion but also facilitates the assessment of collateral blood supply. As another example, accurate rendering of the superficial temporal arteries is valuable in identifying vessel inflammations induced by giant cell arteritis.5 While CTA is an established clinical gold standard for imaging large cerebral arteries and veins,1 an important challenge that currently remains for MDCT-based CTA is its limited performance in imaging small perforating arteries with a diameter below 0.5 mm.4 As a consequence, the relativley invasive artery biopsy procedure remains the current clinical gold standard for the diagnosis of giant cell arteritis.6 The use of indirect conversion energy integrating detectors puts intrinsic limit on the spatial resolution of MDCT, both in-plane and along the z direction. Severe partial volume averaging effect (PVE) and the preferential weighting of high energy photons7 are among major reasons for the relatively poor performance of MDCT-based CTA for imaging iodinated small vessels. Photon counting detector-based CT (PCD-CT) offers potential technological solutions to these challenges MDCT systems face for CTA. When compared to MDCT, the direct conversion design of PCD reduces limitations on both in-plane and through-plane spatial resolution, and the inherent equal weighting of high and low energy photons of PCD-CT systems offers an improvement in the CNR of iodinated vessels. The purpose of this work was to theoretically and experimentally study the potential impacts of the PCD-CT technology to an important component of CTA image package: the maximum intensity projection (MIP) image. MIP is a simple 3D image visualization method to display CTA data sets. Based on source images alone, it can be very challenging to evaluate occlusion conditions since most vessels extend to different z positions. In comparison, a MIP image that extracted information from a much longer z range can provide clearer evidence for an occlusion; in addition, it can effectively enhance the visibility of small collateral vessels. This work first derived the statistical properties of the MIP image, then analyzed how each of the benefits of PCD (improved z resolution; reduced noise autocovariance along z) propagates from the source CT images to the final MIP image. Finally, experiments were performed using a benchtop PCD-CT system and an anthropomorphic CTA phantom to showcase the significantly improved visibility of small perforating arteries.

Proceedings Article | 14 March 2018 Presentation

Deep learning based cone beam CT reconstruction framework using a cascaded neural network architecture (Conference Presentation)

Yinsheng Li, Guang-Hong Chen

Proceedings Volume 10573, 105731J (2018) https://doi.org/10.1117/12.2293916

KEYWORDS: Computed tomography, Image restoration, CT reconstruction, Neural networks, Human subjects, Data modeling, Convolutional neural networks, Diagnostics, Scanners, Statistical analysis

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Proceedings Article | 9 March 2018 Presentation + Paper

Time-resolved C-arm cone beam CT angiography using SMART-RECON: quantification of temporal resolution and reconstruction accuracy

John Garrett, Yinsheng Li, Ke Li, Sebastian Schafer, Charles Strother, Guang-Hong Chen

Proceedings Volume 10573, 105731T (2018) https://doi.org/10.1117/12.2292477

KEYWORDS: Temporal resolution, Reconstruction algorithms, Angiography, Image quality, Arteries, Veins, Computed tomography, Lithium, Error analysis, Sensors

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Proceedings Article | 9 March 2018 Presentation + Paper

Deep learning angiography (DLA): three-dimensional C-arm cone beam CT angiography generated from deep learning method using a convolutional neural network

Juan Montoya, Yinsheng Li, Charles Strother, Guang-Hong Chen

Proceedings Volume 10573, 105731N (2018) https://doi.org/10.1117/12.2293985

KEYWORDS: Machine learning, Artificial intelligence, X-ray imaging, Image segmentation, Cerebral aneurysms, Angiography, Tissues, Neural networks, Data modeling, Bone, Convolutional neural networks, Computed tomography, Image classification, Arteries

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Proceedings Article | 9 March 2018 Presentation + Paper

Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system

Ke Li, Ran Zhang, John Garrett, Yongshuai Ge, Xu Ji, Guang-Hong Chen

Proceedings Volume 10573, 105730W (2018) https://doi.org/10.1117/12.2293921

KEYWORDS: Imaging systems, X-ray imaging, Prototyping, X-rays, Breast imaging, Diffraction gratings, Interferometers

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Proceedings Article | 9 March 2018 Paper

Impact of radiation dose level on CT number accuracy in photon counting CT

Ran Zhang, Juan Cruz-Bastida, Daniel Gomez-Cardona, John Hayes, Ke Li, Guang-Hong Chen

Proceedings Volume 10573, 105734T (2018) https://doi.org/10.1117/12.2293907

KEYWORDS: X-ray computed tomography, Photon counting, X-rays, CT reconstruction, Error analysis, Image processing

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Proceedings Article | 9 March 2018 Paper

Intrinsic limitations on quantification accuracy of dual energy CT at low dose levels

Juan Cruz-Bastida, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 10573, 105734L (2018) https://doi.org/10.1117/12.2293963

KEYWORDS: X-ray computed tomography, Dual energy imaging, X-rays, Data acquisition, Image filtering, Medicine, Image quality, X-ray imaging, Optical filters, Signal attenuation

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Proceedings Article | 9 March 2018 Paper

Noise and spatial resolution characteristics of unregularized statistical iterative reconstruction: an experimental phantom study

John Hayes, Daniel Gomez-Cardona, John Garrett, Ran Zhang, Guang-Hong Chen

Proceedings Volume 10573, 1057330 (2018) https://doi.org/10.1117/12.2293974

KEYWORDS: Modulation transfer functions, Spatial resolution, Denoising, X-ray computed tomography, Image quality, Image filtering, Complex systems, Imaging systems, Fluctuations and noise

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Proceedings Article | 9 March 2018 Paper

Task-driven optimization of an experimental photon counting detector CT system for intracranial hemorrhage detection

Xu Ji, Ran Zhang, Guang-Hong Chen, Ke Li

Proceedings Volume 10573, 105731P (2018) https://doi.org/10.1117/12.2293942

KEYWORDS: Sensors, Head, Imaging systems, Photon counting, X-ray computed tomography, Apodization, Modulation transfer functions, Computed tomography, Performance modeling, X-rays

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Proceedings Article | 9 March 2017 Presentation + Paper

Dependence of quantitative accuracy of CT perfusion imaging on system parameters

Ke Li, Guang-Hong Chen

Proceedings Volume 10132, 101320D (2017) https://doi.org/10.1117/12.2255519

KEYWORDS: Imaging systems, Computed tomography, Systems modeling, Deconvolution, Image processing, 3D image processing, Image acquisition, Diagnostics, Ischemic stroke, Tissues, Signal processing, Numerical simulations, Brain

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Proceedings Article | 9 March 2017 Presentation + Paper

Potential bias in signal estimation for grating-based x-ray multi-contrast imaging

Xu Ji, Yongshuai Ge, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 10132, 1013219 (2017) https://doi.org/10.1117/12.2254429

KEYWORDS: Signal detection, X-ray detectors, X-ray imaging, X-rays, Phase contrast, Absorption, Data acquisition, Visibility, Sensors, Photon counting, Numerical simulations, Phase measurement, Interferometers, Statistical analysis, Photons

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Proceedings Article | 9 March 2017 Presentation + Paper

Signal and noise characteristics of a CdTe-based photon counting detector: cascaded systems analysis and experimental studies

Xu Ji, Ran Zhang, Yongshuai Ge, Guang-Hong Chen, Ke Li

Proceedings Volume 10132, 1013207 (2017) https://doi.org/10.1117/12.2255063

KEYWORDS: Photon counting, Sensors, Image processing, Interference (communication), X-rays, Modulation transfer functions, Signal detection, Cadmium, Systems modeling, X-ray imaging, Medical imaging, Single photon, X-ray detectors

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Proceedings Article | 9 March 2017 Presentation + Paper

Low signal correction scheme for low dose CBCT: the good, the bad, and the ugly

Daniel Gomez-Cardona, John Hayes, Ran Zhang, Ke Li, Juan Pablo Cruz-Bastida, Guang-Hong Chen

Proceedings Volume 10132, 101320Z (2017) https://doi.org/10.1117/12.2255531

KEYWORDS: Computed tomography, Anisotropic diffusion, Imaging systems, Digital filtering, Smoothing, Interference (communication), Spatial resolution, Diffusion, Image filtering, Medical imaging, Statistical analysis

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Proceedings Article | 9 March 2017 Paper

Denoised ordered subset statistically penalized algebraic reconstruction technique (DOS-SPART) in digital breast tomosynthesis

John Garrett, Yinsheng Li, Ke Li, Guang-Hong Chen

Proceedings Volume 10132, 101324F (2017) https://doi.org/10.1117/12.2255584

KEYWORDS: Digital breast tomosynthesis, Reconstruction algorithms, Breast, Optimization (mathematics), Computed tomography, Spatial resolution, Mammography, Image quality, 3D image processing, Cancer, 3D image reconstruction

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Proceedings Article | 9 March 2017 Presentation + Paper

Pushing the boundaries of diagnostic CT systems for high spatial resolution imaging tasks

Juan P. Cruz-Bastida, Daniel Gomez-Cardona, John Garrett, Timothy Szczykutowicz, Guang-Hong Chen, Ke Li

Proceedings Volume 10132, 101320F (2017) https://doi.org/10.1117/12.2255587

KEYWORDS: Spatial resolution, Diagnostics, Computed tomography, Imaging systems, Information fusion, In vivo imaging, Image quality, Signal to noise ratio, Fluctuations and noise, CT reconstruction, Lung, Bone, X-ray computed tomography, Medicine, Sensors

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Proceedings Article | 9 March 2017 Paper

Image quality improvement in MDCT cardiac imaging via SMART-RECON method

Yinsheng Li, Ximiao Cao, Zhanfeng Xing, Xuguang Sun, Jiang Hsieh, Guang-Hong Chen

Proceedings Volume 10132, 101322Z (2017) https://doi.org/10.1117/12.2254644

KEYWORDS: Temporal resolution, Computed tomography, Human subjects, Cardiac imaging, Angiography, Scanners, Data acquisition, Imaging systems, Cones, Image restoration, Image quality, Reconstruction algorithms, Arteries, Medicine, X-ray computed tomography

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Proceedings Article | 9 March 2017 Paper

Weighted singular value decomposition (wSVD) to improve the radiation dose efficiency of grating-based x-ray phase contrast imaging with a photon counting detector

Xu Ji, Yongshuai Ge, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 10132, 101325I (2017) https://doi.org/10.1117/12.2255014

KEYWORDS: Imaging systems, Signal to noise ratio, Phase contrast, Denoising, Interference (communication), Interferometers, Photon counting, Sensors, Visibility, X-ray detectors, X-ray imaging, X-rays

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Proceedings Article | 5 April 2016 Paper

Reduction of truncation artifacts in CT images via a discriminative dictionary representation method

Yang Chen, Ke Li, Yinsheng Li, Jiang Hsieh, Guang-Hong Chen

Proceedings Volume 9783, 97831D (2016) https://doi.org/10.1117/12.2217114

KEYWORDS: Associative arrays, Computed tomography, Human subjects, Chemical species, X-ray computed tomography, Image processing, Medicine, Lithium, Sensors, Collimation

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Proceedings Article | 31 March 2016 Paper

Noise power spectrum studies of CT systems with off-centered image object and bowtie filter

Daniel Gomez-Cardona, Juan Cruz-Bastida, Ke Li, Adam Budde, Jiang Hsieh, Guang-Hong Chen

Proceedings Volume 9783, 97833A (2016) https://doi.org/10.1117/12.2217441

KEYWORDS: Image filtering, Computed tomography, Optical filters, Signal attenuation, Sensors, Medical imaging, Medicine, X-rays, X-ray computed tomography, Numerical simulations

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Proceedings Article | 22 March 2016 Paper

Noise characteristics of CT perfusion imaging: how does noise propagate from source images to final perfusion maps?

Ke Li, Guang-Hong Chen

Proceedings Volume 9783, 978310 (2016) https://doi.org/10.1117/12.2216293

KEYWORDS: Computed tomography, Signal to noise ratio, Image quality, Ischemic stroke, Data acquisition, Numerical simulations, Niobium, X-ray computed tomography, In vivo imaging

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Proceedings Article | 22 March 2016 Paper

Potential use of microbubbles (MBs) as contrast material in x-ray dark field (DF) imaging: How does the DF signal change with the characteristic parameters of the MBs?

Ran Zhang, Bin Qin, Yongshuai Ge, Bruce Whiting, Ke Li, Flordeliza Villanueva, Guang-Hong Chen

Proceedings Volume 9783, 97830N (2016) https://doi.org/10.1117/12.2216322

KEYWORDS: X-rays, X-ray imaging, Absorption, Gold, Imaging systems, Image enhancement, Nanoparticles, Signal detection, Polymers, Ultrasonography

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Proceedings Article | 22 March 2016 Paper

Mask free intravenous 3D digital subtraction angiography (IV 3D-DSA) from a single C-arm acquisition

Yinsheng Li, Kai Niu, Pengfei Yang, Beveley Aagaard-Kienitz, David Niemann, Azam Ahmed, Charles Strother, Guang-Hong Chen

Proceedings Volume 9783, 97830V (2016) https://doi.org/10.1117/12.2216869

KEYWORDS: Cones, Angiography, Reconstruction algorithms, 3D image enhancement, 3D acquisition, Computed tomography, 3D image processing, Image restoration, Tomography, In vivo imaging, Numerical simulations, Image segmentation, Data acquisition, Metals, 3D image reconstruction

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Proceedings Article | 22 March 2016 Paper

Reduction of beam hardening artifacts in cone-beam CT imaging via SMART-RECON algorithm

Yinsheng Li, John Garrett, Guang-Hong Chen

Proceedings Volume 9783, 97830W (2016) https://doi.org/10.1117/12.2216882

KEYWORDS: Cones, X-ray computed tomography, Reconstruction algorithms, Data acquisition, Algorithm development, X-rays, Automatic exposure, Automatic control, Diagnostics, Tomography, X-ray imaging, Numerical simulations, Photons, Image restoration, Bone

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Proceedings Article | 22 March 2016 Paper

C-arm cone beam CT perfusion imaging using the SMART-RECON algorithm to improve temporal sampling density and temporal resolution

Yinsheng Li, Kai Niu, Ke Li, Sebastian Schafer, Kevin Royalty, Charles Strother, Guang-Hong Chen

Proceedings Volume 9783, 97830U (2016) https://doi.org/10.1117/12.2216838

KEYWORDS: Reconstruction algorithms, Temporal resolution, Algorithm development, Computer simulations, In vivo imaging, Computed tomography, Tomography, Image restoration, Denoising, Imaging systems, Tissues, X-ray computed tomography, Blood, Brain mapping, Brain

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Proceedings Article | 22 March 2016 Paper

X-ray differential phase contrast imaging using a grating interferometer and a single photon counting detector

Yongshuai Ge, Ran Zhang, Ke Li, Guang-Hong Chen

Proceedings Volume 9783, 97830M (2016) https://doi.org/10.1117/12.2216321

KEYWORDS: X-rays, Visibility, Interferometers, Sensors, Photons, X-ray imaging, Imaging systems, X-ray detectors, Single photon, Phase contrast

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Proceedings Article | 18 March 2015 Paper

Ultra low radiation dose digital subtraction angiography (DSA) imaging using low rank constraint

Kai Niu, Yinsheng Li, Sebastian Schafer, Kevin Royalty, Yijing Wu, Charles Strother, Guang-Hong Chen

Proceedings Volume 9412, 94121O (2015) https://doi.org/10.1117/12.2082070

KEYWORDS: Image processing, Denoising, Data acquisition, Angiography, Medical imaging, Arteries, Algorithm development, In vivo imaging, Optimization (mathematics), Image quality

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Proceedings Article | 18 March 2015 Paper

Noise performance studies of model-based iterative reconstruction (MBIR) as a function of kV, mA and exposure level: Impact on radiation dose reduction and image quality

Daniel Gomez-Cardona, Ke Li, Meghan Lubner, Perry Pickhardt, Guang-Hong Chen

Proceedings Volume 9412, 941238 (2015) https://doi.org/10.1117/12.2082334

KEYWORDS: X-ray computed tomography, Image quality, Model-based design, X-rays, Computed tomography, Performance modeling, Imaging systems, Liver, In vivo imaging, Medical imaging

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Proceedings Article | 18 March 2015 Paper

Imaging task-based optimal kV and mA selection for CT radiation dose reduction: from filtered backprojection (FBP) to statistical model based iterative reconstruction (MBIR)

Ke Li, Daniel Gomez-Cardona, Meghan Lubner, Perry Pickhardt, Guang-Hong Chen

Proceedings Volume 9412, 94121M (2015) https://doi.org/10.1117/12.2082357

KEYWORDS: Statistical analysis, Computed tomography, Image filtering, Diagnostics, Optical filters, X-ray computed tomography, Spatial resolution, Eye models, Optimization (mathematics), X-rays

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Proceedings Article | 18 March 2015 Paper

Low rank approximation (LRA) based noise reduction in spectral-resolved x-ray imaging using photon counting detector

Yinsheng Li, Jiang Hsieh, Guang-Hong Chen

Proceedings Volume 9412, 941212 (2015) https://doi.org/10.1117/12.2081947

KEYWORDS: Photon counting, Sensors, Denoising, Data acquisition, X-ray imaging, X-rays, Iodine, Image processing, Computer simulations, Imaging spectroscopy

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Proceedings Article | 18 March 2015 Paper

Statistical model based iterative reconstruction in myocardial CT perfusion: exploitation of the low dimensionality of the spatial-temporal image matrix

Yinsheng Li, Kai Niu, Guang-Hong Chen

Proceedings Volume 9412, 94123N (2015) https://doi.org/10.1117/12.2081944

KEYWORDS: Computed tomography, X-ray computed tomography, Statistical analysis, Medical imaging, Image quality, Reconstruction algorithms, Image quality standards, Numerical simulations, Computer simulations, Image compression

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Proceedings Article | 18 March 2015 Paper

Anatomical background noise power spectrum in differential phase contrast breast images

John Garrett, Yongshuai Ge, Ke Li, Guang-Hong Chen

Proceedings Volume 9412, 94121J (2015) https://doi.org/10.1117/12.2081008

KEYWORDS: Breast, Mammography, Absorption, Imaging systems, Phase contrast, X-rays, Breast imaging, X-ray imaging, Spatial frequencies, Sensors

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Proceedings Article | 18 March 2015 Paper

Absorption imaging performance in a future Talbot-Lau interferometer based breast imaging system

Yongshuai Ge, Wei Zhao, John Garrett, Ke Li, Guang-Hong Chen

Proceedings Volume 9412, 94123X (2015) https://doi.org/10.1117/12.2081013

KEYWORDS: Imaging systems, Breast imaging, Absorption, Photons, X-rays, Sensors, Monte Carlo methods, X-ray imaging, Optical design, Breast

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Proceedings Article | 18 March 2015 Paper

New signal extraction method in x-ray differential phase contrast imaging with a tilted collinear analyzer grating

Yongshuai Ge, John Garrett, Ke Li, Guang-Hong Chen

Proceedings Volume 9412, 94120H (2015) https://doi.org/10.1117/12.2081015

KEYWORDS: X-rays, Diffraction gratings, Phase contrast, Signal detection, X-ray imaging, Sensors, Absorption, Data acquisition, Diffraction, Imaging systems

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Proceedings Article | 18 March 2015 Paper

Methods to mitigate data truncation artifacts in multi-contrast tomosynthesis image reconstructions

John Garrett, Yongshuai Ge, Ke Li, Guang-Hong Chen

Proceedings Volume 9412, 941225 (2015) https://doi.org/10.1117/12.2081017

KEYWORDS: Sensors, Absorption, Phase contrast, X-rays, Data acquisition, X-ray imaging, Tomography, Breast, Image restoration, Medical imaging

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Proceedings Article | 19 March 2014 Paper

Noise performance of statistical model based iterative reconstruction in clinical CT systems

Ke Li, Jie Tang, Guang-Hong Chen

Proceedings Volume 9033, 90335J (2014) https://doi.org/10.1117/12.2043974

KEYWORDS: Computed tomography, Statistical analysis, CT reconstruction, Scanners, 3D image processing, 3D image reconstruction, Image quality, 3D metrology, Iodine, Image processing

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Proceedings Article | 19 March 2014 Paper

A patient-specific scatter artifacts correction method

Wei Zhao, Stephen Brunner, Kai Niu, Sebastian Schafer, Kevin Royalty, Guang-Hong Chen

Proceedings Volume 9033, 903310 (2014) https://doi.org/10.1117/12.2043923

KEYWORDS: Monte Carlo methods, Calibration, Data modeling, X-ray computed tomography, X-ray sources, Convolution, X-rays, Image segmentation, Numerical simulations, Computed tomography

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Proceedings Article | 19 March 2014 Paper

Fast data acquisition method in X-ray differential phase contrast imaging using a new grating design

Yongshuai Ge, Ke Li, John Garrett, Guang-Hong Chen

Proceedings Volume 9033, 90330B (2014) https://doi.org/10.1117/12.2043886

KEYWORDS: Data acquisition, X-rays, Optical design, X-ray imaging, Sensors, Phase contrast, X-ray detectors, Diffraction gratings, Fringe analysis, Absorption

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Proceedings Article | 19 March 2014 Paper

Statistical image reconstruction via denoised ordered-subset statistically penalized algebraic reconstruction technique (DOS-SPART)

Yinsheng Li, Kai Niu, Jie Tang, Guang-Hong Chen

Proceedings Volume 9033, 90330U (2014) https://doi.org/10.1117/12.2043491

KEYWORDS: Reconstruction algorithms, Image restoration, Denoising, Medical imaging, Data modeling, Image denoising, Image processing, Photon counting, Statistical modeling, Numerical simulations

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Proceedings Article | 19 March 2014 Paper

Statistical signal estimation methods in X-ray differential phase contrast imaging

Yongshuai Ge, Ke Li, Guang-Hong Chen

Proceedings Volume 9033, 90330G (2014) https://doi.org/10.1117/12.2043938

KEYWORDS: Statistical analysis, X-rays, X-ray imaging, Phase contrast, Interference (communication), Statistical modeling, Numerical simulations, Visibility, X-ray detectors, Data acquisition

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Proceedings Article | 19 March 2014 Paper

Impact of norm selections on the performance of four-dimensional cone-beam computed tomography (4DCBCT) using PICCS

Yinsheng Li, Jie Tang, Guang-Hong Chen

Proceedings Volume 9033, 903308 (2014) https://doi.org/10.1117/12.2043509

KEYWORDS: Image restoration, Computed tomography, Image quality, CT reconstruction, Reconstruction algorithms, Compressed sensing, Temporal resolution, Medical imaging, Data acquisition, Signal to noise ratio

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Proceedings Article | 19 March 2014 Paper

Investigation of the potential causes of partial scan artifacts in dynamic CT myocardial perfusion imaging

Yinghua Tao, Michael Speidel, Timothy Szczykutowicz, Guang-Hong Chen

Proceedings Volume 9033, 90332B (2014) https://doi.org/10.1117/12.2043838

KEYWORDS: Computed tomography, X-ray computed tomography, Scanners, In vivo imaging, Signal attenuation, X-rays, Numerical simulations, Blood, Electrocardiography, Optical simulations

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Proceedings Article | 19 March 2014 Paper

Impact of redundant ray weighting on motion artifact in a statistical iterative reconstruction framework

Yinghua Tao, Jie Tang, Michael Speidel, Guang-Hong Chen

Proceedings Volume 9033, 90332X (2014) https://doi.org/10.1117/12.2043824

KEYWORDS: In vivo imaging, Numerical simulations, Data acquisition, Computed tomography, Fluctuations and noise, Infrared imaging, Statistical analysis, Image quality, Medical imaging, Zoom lenses

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Proceedings Article | 19 March 2014 Paper

Cramér-Rao lower bound in differential phase contrast imaging and its application in the optimization of data acquisition systems

Yongshuai Ge, Ke Li, Guang-Hong Chen

Proceedings Volume 9033, 90330F (2014) https://doi.org/10.1117/12.2043930

KEYWORDS: X-rays, X-ray imaging, Phase contrast, Visibility, Interference (communication), Imaging systems, Sensors, Photon counting, Phase retrieval, Photons

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