Dr. Min Qu Profile

Dr. Min Qu

Applied Research Engineer

SPIE Involvement:

Author

Area of Expertise:

Photoacoustic Imaging , Plantable device , Magneto-photo-acoustic imaging

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Company Website

Publications (2)

Proceedings Article | 24 February 2010 Paper

Combined photoacoustic and magneto-motive ultrasound imaging

Min Qu, Seungsoo Kim, Mohammad Mehrmohammadi, Srivalleesha Mallidi, Pratixa Joshi, Kimberly Homan, Yun-Sheng Chen, Stanislav Emelianov

Proceedings Volume 7564, 756433 (2010) https://doi.org/10.1117/12.842406

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Magnetism, Tissue optics, Nanoparticles, Tissues, Transducers, Photoacoustic imaging, Image resolution, Absorption

Read Abstract +

Proceedings Article | 13 February 2010 Paper

Combined photothermal therapy and magneto-motive ultrasound imaging using multifunctional nanoparticles

Mohammad Mehrmohammadi, Li Ma, Yun-Sheng Chen, Min Qu, Pratixa Joshi, Raeanna Chen, Keith Johnston, Stanislav Emelianov

Proceedings Volume 7574, 757405 (2010) https://doi.org/10.1117/12.843055

KEYWORDS: Nanoparticles, Magnetism, Ultrasonography, Tissue optics, Tissues, Tumors, Laser therapeutics, Iron, Gold, Imaging systems

Read Abstract +

Photothermal therapy is a laser-based non-invasive technique for cancer treatment. Photothermal therapy can be enhanced by employing metal nanoparticles that absorb the radiant energy from the laser leading to localized thermal damages. Targeting of nanoparticles leads to more efficient uptake and localization of photoabsorbers thus increasing the effectiveness of the treatment. Moreover, efficient targeting can reduce the required dosage of photoabsorbers; thereby reducing the side effects associated with general systematic administration of nanoparticles. Magnetic nanoparticles, due to their small size and response to an external magnetic field gradient have been proposed for targeted drug delivery. In this study, we investigate the applicability of multifunctional nanoparticles (e.g., magneto-plasmonic nanoparticles) and magneto-motive ultrasound imaging for image-guided photothermal therapy. Magneto-motive ultrasound imaging is an ultrasound based imaging technique capable of detecting magnetic nanoparticles indirectly by utilizing a high strength magnetic field to induce motion within the magnetically labeled tissue. The ultrasound imaging is used to detect the internal tissue motion. Due to presence of the magnetic component, the proposed multifunctional nanoparticles along with magneto-motive ultrasound imaging can be used to detect the presence of the photo absorbers. Clearly the higher concentration of magnetic carriers leads to a monotonic increase in magneto-motive ultrasound signal. Thus, magnetomotive ultrasound can determine the presence of the hybrid agents and provide information about their location and concentration. Furthermore, the magneto-motive ultrasound signal can indicate the change in tissue elasticity - a parameter that is expected to change significantly during the photothermal therapy. Therefore, a comprehensive guidance and assessment of the photothermal therapy may be feasible through magneto-motive ultrasound imaging and magnetoplasmonic nanoparticles.

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