Dr. Mohammad Mehrmohammadi Profile

Dr. Mohammad Mehrmohammadi

Associate Professor at Univ of Rochester

SPIE Involvement:

Conference Program Committee | Author

Websites:

Personal Website

Publications (20)

Proceedings Article | 1 April 2024 Presentation + Paper

The efficacy of an ultrasound ring-array transducer for hyperthermia generation

David Bustamante, Yan Yan, Trevor Mitcham, Nebojsa Duric, Mohammad Mehrmohammadi

Proceedings Volume 12932, 129320E (2024) https://doi.org/10.1117/12.3006248

KEYWORDS: Acoustics, Ultrasound transducers, Temperature metrology, Transducers, Thermography, Tissues, Aberration correction, Ultrasonography, In vitro testing, Cancer

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In mild hyperthermia (MHTh), targeted tumors are heated to approximately 41 to 44°C, typically to enhance chemo-, radiation, and/or immunotherapy. This study demonstrates the efficacy of a ring-array ultrasound (US) transducer in generating and monitoring MHTh in heterogeneous media. A ring-array provides enhanced focusing and heat localization compared to conventional linear-array US. We simulated scenarios using either one, two, or four 128-element linear-array transducers, or a 256-element ring-array transducer, to generate focused US profiles. The full width half maximum (FWHM) was measured to quantify the results. The ring-array achieved the most accurate and localized focal pressure profile with a focal spot size of 2×2mm. In a simulated heterogeneous breast model, sound speed (SS) compensation with a ring-array resulted in more efficient acoustic focusing than non-compensated fields. The focal point without SS compensation shifted spatially from its target due to acoustic aberrations, highlighting the importance of aberration correction for precise heat localization. Additionally, the ring-array's heat generation capability was evaluated in-vitro using a tissue-mimicking phantom, where the temperature at the focal point was increased by 6°C in 12 minutes and was sustainable. Lastly, the capability of a ring-array to track temperature was evaluated using US tomography (UST) in another in-vitro experiment. Here, a cylindrical inclusion in a tissue-mimicking phantom was filled with preheated water and allowed to passively cool from 45°C to 25°C. A ring-array tracked the temperature changes based on SS images with a mean error of 0.06±0.28°C. In summary, a ring-array transducer (1) achieved the best focal profile compared to standard linear transducers, (2) accomplished superior aberration correction using SS images, resulting in better aberration-free focusing in heterogeneous media, (3) generated sustainable heat at a focal point, and (4) accurately monitored temperature changes with UST.

Proceedings Article | 13 March 2024 Presentation

Photoacoustic-Brillouin multimodal imaging modality

Chenjun Shi, Yan Yan, Mohammad Mehrmohammadi, Jitao Zhang

Proceedings Volume PC12844, PC128440H (2024) https://doi.org/10.1117/12.3002144

KEYWORDS: Multimodal imaging, Refractive index, Optical properties, Materials properties, Photoacoustic spectroscopy, Microscopy, Integrated optics, Deionized water

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Proceedings Article | 27 May 2022 Presentation + Paper

A longitudinal study of cervical tissue composition changes during normal pregnancy in mice using spectroscopic photoacoustic

Yan Yan, Jose Galaz, Maryam Basij, Steven Yellon, Nardhy Gomez-Lopez, Mohammad Mehrmohammadi

Proceedings Volume 12144, 121440G (2022) https://doi.org/10.1117/12.2621577

KEYWORDS: Photoacoustic spectroscopy, Collagen, Tissues, Tissue optics, Spectroscopy, Cervix, Photoacoustic imaging, Imaging spectroscopy, Visualization, Optical properties

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Proceedings Article | 4 April 2022 Presentation

Ultrasound and photoacoustic imaging for gastric tube placement guidance

Samuel John, Yoseph Adie, Nasrin Nesha, Loay Kabbani, Mohammad Mehrmohammadi

Proceedings Volume PC12038, PC1203804 (2022) https://doi.org/10.1117/12.2627512

KEYWORDS: Ultrasonography, Colon, Photoacoustic imaging, Tissues, Point-of-care devices, Optical fibers, Fluoroscopy, X-rays, Visualization, Tissue optics

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SPIE Journal Paper | 9 November 2021

Endocavity ultrasound and photoacoustic system for fetal and maternal imaging: design, implementation, and ex-vivo validation

Yan Yan, Edgar Hernandez-Andrade, Maryam Basij, Suhail Alshahrani, Sirisha Kondle, Barrington Brown, Juri Gelovani, Sonia Hassan, Chaur-Dong Hsu, Mohammad Mehrmohammadi

JMI, Vol. 8, Issue 06, 066001, (November 2021) https://doi.org/10.1117/12.10.1117/1.JMI.8.6.066001

KEYWORDS: Imaging systems, Fetus, Brain, Blood, Ultrasonography, Photoacoustic spectroscopy, Neuroimaging, In vivo imaging, Blood circulation, Oximetry

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SPIE Journal Paper | 7 October 2020 Open Access

Photoacoustic image improvement based on a combination of sparse coding and filtering

Ebrahim Najafzadeh, Parastoo Farnia, Saeedeh Lavasani, Maryam Basij, Yan Yan, Hossein Ghadiri, Alireza Ahmadian, Mohammad Mehrmohammadi

JBO, Vol. 25, Issue 10, 106001, (October 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.10.106001

KEYWORDS: Denoising, Signal to noise ratio, Interference (communication), Image quality, Photoacoustic spectroscopy, Wavelets, Image compression, Signal detection, Linear filtering, Tissue optics

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SPIE Journal Paper | 26 April 2019 Open Access

All-reflective ring illumination system for photoacoustic tomography

Suhail Salem Alshahrani, Yan Yan, Naser Alijabbari, Alexander Pattyn, Ivan Avrutsky, Eugene Malyarenko, Joemini Poudel, Mark Anastasio, Mohammad Mehrmohammadi

JBO, Vol. 24, Issue 04, 046004, (April 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.4.046004

KEYWORDS: Imaging systems, Reflectors, Transducers, Acquisition tracking and pointing, Photoacoustic tomography, Mirrors, Breast, Tissues, Breast cancer, Tissue optics

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Proceedings Article | 27 February 2019 Paper

Application of Demons algorithm in ultrasound elastography using B-mode ultrasound images

Ali Kafaei Zad Tehrani, Moein Mozaffarzadeh, Zahra Mardi, Seyed Hani Hozhabr, Mohammad Mehrmohammadi, Bahador Makkiabadi

Proceedings Volume 10878, 108786P (2019) https://doi.org/10.1117/12.2508817

KEYWORDS: Ultrasonography, Image registration, Tumors, Elastography, Tissues, Chromium, Optimization (mathematics), Biomedical engineering, Rigid registration, Computer simulations

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Proceedings Article | 27 February 2019 Paper

An advanced sparsity-based photoacoustic image reconstruction algorithm for linear-array transducer scenario

Roya Paridar, Moein Mozaffarzadeh, Maryam Basij, Mohammad Mehrmohammadi, Mahdi Orooji

Proceedings Volume 10878, 108786O (2019) https://doi.org/10.1117/12.2508039

KEYWORDS: Signal to noise ratio, Reconstruction algorithms, Image enhancement, Sensors, Algorithm development, Interference (communication), Photoacoustic spectroscopy, Image restoration, Image quality

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Proceedings Article | 27 February 2019 Paper

Artifact reduction using minimum variance-based sparse subarray technique in linear-array photoacoustic tomography

Roya Paridar, Moein Mozaffarzadeh, Mohammad Mehrmohammadi, Maryam Basij, Mahdi Orooji

Proceedings Volume 10878, 108786M (2019) https://doi.org/10.1117/12.2508004

KEYWORDS: Phased arrays, Signal to noise ratio, Reconstruction algorithms, Sensors, Photoacoustic tomography, Image resolution, Denoising, Acoustics, Interference (communication), Photoacoustic imaging

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Proceedings Article | 27 February 2019 Paper

Delay-multiply-and-standard-deviation weighting factor improves image quality in linear-array photoacoustic tomography

Roya Paridar, Moein Mozaffarzadeh, Mohammad Mehrmohammadi, Maryam Basij, Mahdi Orooji

Proceedings Volume 10878, 108786N (2019) https://doi.org/10.1117/12.2508027

KEYWORDS: Reconstruction algorithms, Image quality, Tissues, Photoacoustic tomography, Signal to noise ratio, Image resolution, Denoising, Interference (communication), Sensors

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Proceedings Article | 23 March 2018 Presentation + Paper

Combined phased-array ultrasound and photoacoustic endoscope for gynecologic cancer imaging applications

Maryam Basij, Yan Yan, Suhail Alshahrani, Samaresh Sau, Arun Iyer, Shelly Seward, Jacob Burmeister, Michael Dominello, Mohammad Mehrmohammadi

Proceedings Volume 10580, 105800V (2018) https://doi.org/10.1117/12.2296563

KEYWORDS: Endoscopes, Cancer, Cervical cancer, Polishing, Tissues, Spectroscopy, Ovarian cancer, Ultrasonography, Photoacoustic spectroscopy, Imaging spectroscopy

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Proceedings Article | 14 March 2018 Presentation

Acoustic and optical compensated, full-ring photoacoustic tomography: a simulation study (Conference Presentation)

Alexander Pattyn, Yan Yan, Mohammad Mehrmohammadi

Proceedings Volume 10580, 1058003 (2018) https://doi.org/10.1117/12.2296581

KEYWORDS: Acoustics, Acquisition tracking and pointing, Tissue optics, Photoacoustic tomography, Monte Carlo methods, Tissues, Diffusion, Pathology, Cancer, Signal attenuation

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Proceedings Article | 14 March 2018 Presentation

Ultrasound, elasticity, and photoacoustic imaging of cervix: towards a more accurate prediction of preterm delivery (Conference Presentation)

Yan Yan, Jiayin Dong, Adeel Siddiqu, Yashashree Majalikar, Maryam Basij, Edgar Hernandez-Andrade, Sonia Hassan, Mohammad Mehrmohammadi

Proceedings Volume 10580, 105800U (2018) https://doi.org/10.1117/12.2296469

KEYWORDS: Ultrasonography, Cervix, Tissues, Photoacoustic imaging, Elastography, Tissue optics, Imaging systems, Collagen, Electroluminescence, Medicine

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Proceedings Article | 6 March 2018 Presentation + Paper

An advanced photoacoustic tomography system based on a ring geometry design

Suhail Alshahrani, Yan Yan, Ivan Avrutsky, Eugene Malyarenko, Mark Anastasio, Mohammad Mehrmohammadi

Proceedings Volume 10580, 1058005 (2018) https://doi.org/10.1117/12.2296595

KEYWORDS: Breast, Acquisition tracking and pointing, Breast cancer, Tissue optics, Transducers, Mirrors, Tissues, Signal detection, Mammography, Photoacoustic tomography

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Proceedings Article | 6 March 2018 Presentation + Paper

Ultrasound and photoacoustic imaging for enhanced image-guided endovenous laser ablation procedures

Yan Yan, Samuel John, Mahboobeh Ghalehnovi, Loay Kabbani, Nicole Kennedy , Mohammad Mehrmohammadi

Proceedings Volume 10580, 105800T (2018) https://doi.org/10.1117/12.2296467

KEYWORDS: Laser ablation, Veins, Optical fibers, Tissues, Visualization, Temperature metrology, Ultrasonography, Laser tissue interaction, Thermometry, Transducers

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SPIE Journal Paper | 14 February 2018 Open Access

Enhanced linear-array photoacoustic beamforming using modified coherence factor

Moein Mozaffarzadeh, Yan Yan, Mohammad Mehrmohammadi, Bahador Makkiabadi

JBO, Vol. 23, Issue 02, 026005, (February 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.026005

KEYWORDS: Signal detection, Image quality, Photoacoustic spectroscopy, Imaging systems, Interference (communication), Image resolution, Signal to noise ratio, Phased arrays, Reconstruction algorithms, Target detection

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Proceedings Article | 29 March 2013 Paper

Vibro-acoustography with 1.75D ultrasound array transducer for detection and localization of permanent prostate brachytherapy seeds: ex vivo study

Mohammad Mehrmohammadi, Azra Alizad, Randall Kinnick, Brian Davis, Mostafa Fatemi

Proceedings Volume 8675, 86750W (2013) https://doi.org/10.1117/12.2007367

KEYWORDS: Tissues, Prostate, Ultrasonography, Transducers, Acoustics, Prostate cancer, Radiotherapy, Computed tomography, Detector arrays, Scanners

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Proceedings Article | 24 February 2010 Paper

Combined photoacoustic and magneto-motive ultrasound imaging

Min Qu, Seungsoo Kim, Mohammad Mehrmohammadi, Srivalleesha Mallidi, Pratixa Joshi, Kimberly Homan, Yun-Sheng Chen, Stanislav Emelianov

Proceedings Volume 7564, 756433 (2010) https://doi.org/10.1117/12.842406

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Magnetism, Tissue optics, Nanoparticles, Tissues, Transducers, Photoacoustic imaging, Image resolution, Absorption

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Proceedings Article | 13 February 2010 Paper

Combined photothermal therapy and magneto-motive ultrasound imaging using multifunctional nanoparticles

Mohammad Mehrmohammadi, Li Ma, Yun-Sheng Chen, Min Qu, Pratixa Joshi, Raeanna Chen, Keith Johnston, Stanislav Emelianov

Proceedings Volume 7574, 757405 (2010) https://doi.org/10.1117/12.843055

KEYWORDS: Nanoparticles, Magnetism, Ultrasonography, Tissue optics, Tissues, Tumors, Laser therapeutics, Iron, Gold, Imaging systems

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Photothermal therapy is a laser-based non-invasive technique for cancer treatment. Photothermal therapy can be enhanced by employing metal nanoparticles that absorb the radiant energy from the laser leading to localized thermal damages. Targeting of nanoparticles leads to more efficient uptake and localization of photoabsorbers thus increasing the effectiveness of the treatment. Moreover, efficient targeting can reduce the required dosage of photoabsorbers; thereby reducing the side effects associated with general systematic administration of nanoparticles. Magnetic nanoparticles, due to their small size and response to an external magnetic field gradient have been proposed for targeted drug delivery. In this study, we investigate the applicability of multifunctional nanoparticles (e.g., magneto-plasmonic nanoparticles) and magneto-motive ultrasound imaging for image-guided photothermal therapy. Magneto-motive ultrasound imaging is an ultrasound based imaging technique capable of detecting magnetic nanoparticles indirectly by utilizing a high strength magnetic field to induce motion within the magnetically labeled tissue. The ultrasound imaging is used to detect the internal tissue motion. Due to presence of the magnetic component, the proposed multifunctional nanoparticles along with magneto-motive ultrasound imaging can be used to detect the presence of the photo absorbers. Clearly the higher concentration of magnetic carriers leads to a monotonic increase in magneto-motive ultrasound signal. Thus, magnetomotive ultrasound can determine the presence of the hybrid agents and provide information about their location and concentration. Furthermore, the magneto-motive ultrasound signal can indicate the change in tissue elasticity - a parameter that is expected to change significantly during the photothermal therapy. Therefore, a comprehensive guidance and assessment of the photothermal therapy may be feasible through magneto-motive ultrasound imaging and magnetoplasmonic nanoparticles.

Showing 5 of 20 publications

Conference Committee Involvement (10)