Dr. Oliver F. Stumpp Profile

Dr. Oliver F. Stumpp

SPIE Involvement:

Author

Publications (8)

SPIE Journal Paper | 1 March 2009 Open Access

In vivo confocal imaging of epidermal cell migration and dermal changes post nonablative fractional resurfacing: study of the wound healing process with corroborated histopathologic evidence

Oliver Stumpp, Vikramaditya Bedi, Danica Wyatt, Diana Lac, Zakia Rahman, Kin-Foong Chan

JBO, Vol. 14, Issue 02, 024018, (March 2009) https://doi.org/10.1117/12.10.1117/1.3103316

KEYWORDS: Confocal microscopy, Tissues, Wound healing, In vivo imaging, Statistical analysis, Tissue optics, Skin, Collagen, Biopsy, Microscopes

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SPIE Journal Paper | 1 July 2006 Open Access

Using sandpaper for noninvasive transepidermal optical skin clearing agent delivery

O. Stumpp, Bo Chen, Ashley Welch

JBO, Vol. 11, Issue 04, 041118, (July 2006) https://doi.org/10.1117/12.10.1117/1.2340658

KEYWORDS: Skin, Tissue optics, Optical coherence tomography, In vivo imaging, Light scattering, Biomedical optics, Optical clearing, Tissues, Natural surfaces, Opacity

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SPIE Journal Paper | 1 July 2006 Open Access

Dehydration mechanism of optical clearing in tissue

Christopher Rylander, Oliver Stumpp, Thomas Milner, Nathaniel Kemp, John Mendenhall, Kenneth Diller, Ashley Welch

JBO, Vol. 11, Issue 04, 041117, (July 2006) https://doi.org/10.1117/12.10.1117/1.2343208

KEYWORDS: Scattering, Tissue optics, Optical clearing, Light scattering, Particles, Tissues, Refractive index, Skin, Water, Transmission electron microscopy

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Proceedings Article | 15 April 2005 Paper

Feasibility of extracting tissue optical properties from amplitude OCT data during optical skin clearing

Oliver Stumpp, A.J. Welch, Thomas Milner

Proceedings Volume 5695, (2005) https://doi.org/10.1117/12.585996

KEYWORDS: Tissue optics, Mirrors, Skin, Optical coherence tomography, Signal attenuation, Geometrical optics, Tissues, Optical properties, Light scattering, Natural surfaces

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Proceedings Article | 1 July 2004 Paper

Creating the invisible man

A. Welch, Chris Humphrey, Gracie Vargas, Oliver Stumpp, Chris Rylander

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.537256

KEYWORDS: Skin, Blood vessels, In vivo imaging, Tissues, Blood circulation, Tissue optics, Refractive index, In vitro testing, Collimation, Light scattering

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Proceedings Article | 1 July 2004 Paper

OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyperosmotic agents for optical skin clearing

Oliver Stumpp, A. Welch, Harvinder Gill, Mark Prausnitz

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.529504

KEYWORDS: Skin, Optical coherence tomography, Tissue optics, Er:YAG lasers, Laser ablation, Laser tissue interaction, Natural surfaces, Light scattering, Laser scattering, Tissues

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The purpose of this study is to investigate the feasibility of using microneedles in comparison to Er:YAG skin surface laser ablation as a means to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics such as glycerol into the skin to achieve optical skin clearing. This allows to temporarily reduce scattering of light in otherwise turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT) or therapeutic applications like laser blood vessel coagulation to treat port wine stains in skin. A portable, battery powered Er:YAG laser (Lasette) manufactured by Cell Robotics Inc. was used to produce holes in the stratum corneum and epidermis using individual 400 μs pulses causing localized ablation. Following each laser pulse the tissue was mechanically translated by 1 mm before another pulse was delivered. As an alternative method to the use of an expensive laser source requiring some kind of light scanning mechanism to treat larger skin areas efficiently, microneedles were investigated. They do not require an energy supply, are also pain-free and can be manufactured into arrays allowing treatment of larger skin areas. A single application forms micron scale holes in the stratum corneum through which topically applied skin clearing agents such as glycerol can penetrate into the tissue. In this feasibility study individual microneedles were used to manually induce holes in the skin each spaced approximately 1 mm apart from the other. Upon such epidermal modification by either technique, glycerol was then applied to the tissue surface and amplitude OCT measurements monitored changes of the optical properties of the tissue over time. Due to the geometry of the microneedle used in this study the cross sectional area of each hole in the epidermis was about 68% smaller than the comparable ablation site caused by an individual laser pulse. Results indicate enhanced skin clearing rates due to the induced holes in the stratum corneum in both cases by a factor of 5 to 8. Due to the larger area of laser ablation in comparison to the holes caused by microneedles, overall skin clearing rates are higher with the laser. However, localized data analysis near holes produced by either technique yields comparable results which show an increase in the clearing rate of up to 10 to 13 times over intact skin without any holes.

Proceedings Article | 12 September 2003 Paper

Injection of glycerol into porcine skin for optical skin clearing with needle-free injection gun and determination of agent distribution using OCT and fluorescence microscopy

Oliver Stumpp, Ashley Welch

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476147

KEYWORDS: Skin, Tissue optics, Optical coherence tomography, Tissues, Luminescence, Microscopy, Head, Refraction, Rhodamine, Mirrors

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Proceedings Article | 1 August 2003 Paper

In vivo results using photothermal tomography for imaging cutaneous blood vessels

Bernard Choi, Boris Majaron, Gracie Vargas, Byungjo Jung, Oliver Stumpp, Nicole Kang, Kristen Kelly, Ashley Welch, J. Stuart Nelson

Proceedings Volume 5047, (2003) https://doi.org/10.1117/12.484140

KEYWORDS: Skin, Blood vessels, Infrared imaging, Infrared radiation, Laser irradiation, Infrared cameras, Absorption, In vivo imaging, Tomography, Laser therapeutics

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Showing 5 of 8 publications

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