Dr. Vadim D. Genin Profile

Dr. Vadim D. Genin

Doctoral Candidate at Saratov State Univ

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Publications (9)

Proceedings Article | 29 April 2022 Paper

The novel photosensitizer galactose: lutetium (Lu)-phthalocyanine for photodynamic therapy in tumor-bearing mice

Alla Bucharskaya, Galina Maslyakova, Nikita Navolokin, Georgy Terentyuk, Vanya Mantareva, Vadim Genin, Elina Genina, Valery Tuchin

Proceedings Volume 12192, 121920Z (2022) https://doi.org/10.1117/12.2627759

KEYWORDS: Photodynamic therapy, Tumors, Lutetium, Tissues, Medical research, Cell death, Skin, Photomicroscopy, Laser sources, Inflammation

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Proceedings Article | 4 May 2021 Paper

The assessment of tumor vascularization degree for predicting the effectiveness of plasmonic photothermal and photodynamic therapy

Alla Bucharskaya, Galina Maslyakova, Marina Chekhonatskaya, Svetlana Pakhomy, Dmitry Mudrak, Nikita Navolokin, Georgy Terentyuk, Ekaterina Borisova, Vanya Mantareva, Ivan Angelov, Boris Khlebtsov, Nikolai Khlebtsov, Vadim Genin, Alexey Bashkatov, Elina Genina, Valery Tuchin

Proceedings Volume 11845, 1184508 (2021) https://doi.org/10.1117/12.2590411

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Proceedings Article | 4 May 2021 Paper

Optical properties of model cholangiocarcinoma tissues in the spectral range of 350-2250 nm in laser photothermolysis treatment

Vadim Genin, Alla Bucharskaya, Elina Genina, Georgy Terentyuk, Nikolai Khlebtsov, Valery Tuchin, Alexey Bashkatov

Proceedings Volume 11845, 118450Z (2021) https://doi.org/10.1117/12.2590422

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Proceedings Article | 2 April 2020 Presentation

Photodynamic treatment of cholangiocarcinoma with phthalocyanine compounds in laboratory animals (Conference Presentation)

Ekaterina Borisova, Alla Bucharskaya, Nikita Navolokin, Vadim Genin, Elina Genina, Alexey Bashkatov, Vanya Mantareva, Ivan Angelov

Proceedings Volume 11363, 1136325 (2020) https://doi.org/10.1117/12.2555952

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The new generations of photoactive compounds, which are derivatives of already well-established groups of photosensitizers, together with the modern light sources in the spectral region of their activation and in the PDT window range, are emerging as a reliable phototherapy approach for tumour treatment with higher efficiency. The substitution of a highly hydrophobic phthalocyanine with galactose units could improve the solubility and to decrease significant aggregation in polar solvents. The control group of rats with transplanted cholangiocarcinoma without any treatment was used for comparison of PDT effectiveness. In the second group the white outbred male rats with cholangiocarcinoma lesions were treated using Zn-phthalocyanine, as a typical representative of phthalocyanine photosensitizers with known photodynamic properties and the third group of animals was treated with galactose – Lu-phthalocyanine, as a novel derivative from the same family with two specific differences – presence of galactose and replacing of Zn(II) with Lu(III) ion. To compare the PDT effectiveness of both compounds the same drug doses were applied - 2 mg/kg, applied by intratumoural injection. Diode laser source at 670 nm, on 50 mW output power with power density applied 200 mW/cm2 was applied for 1000 sec to obtain total irradiation dose of 200 J/cm2 for each lesion. 3 days after treatment, the animals were withdrawn from the experiment. Tissue from the central zone and periphery of the tumor was taken for morphological examination and fixed in 10% formalin. Serial paraffin sections were stained with hematoxilin-eosin and by immunohistochemical staining with antibodies to proliferation marker Ki-67 and apoptosis marker BAX. After photodynamic therapy, pronounced necrobiotic changes in combination with an inflammatory reaction were developed at the central zone of tumors. The dystrophic changes, reduction of proliferation and development of apoptosis in tumor cells were observed on tumor periphery as well.

Proceedings Article | 3 June 2019 Paper

Research and development of effective optical technologies for diagnostics in dermatology

Vadim Genin, Prisca Rakotomanga, Sergey Zaytsev, Elina Genina, Ekaterina Lazareva, Grégoire Khairallah, Marine Amouroux, Charles Soussen, Hang Chen, Wei Feng, Dan Zhu, Alexey Bashkatov, Walter Blondel, Valery Tuchin

Proceedings Volume 11065, 1106505 (2019) https://doi.org/10.1117/12.2528700

KEYWORDS: Skin, Optical coherence tomography, Tissue optics, Luminescence, In vivo imaging, Scattering, Absorption, Optical clearing, Photons, Transparency

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SPIE Journal Paper | 23 August 2018 Open Access

Measurement of tissue optical properties in the context of tissue optical clearing

Alexey Bashkatov, Kirill Berezin, Konstantin Dvoretskiy, Maria Chernavina, Elina Genina, Vadim Genin, Vyacheslav Kochubey, Ekaterina Lazareva, Alexander Pravdin, Marina Shvachkina, Polina Timoshina, Daria Tuchina, Dmitry Yakovlev, Irina Yu Yanina, Olga Zhernovaya, Valery Tuchin

JBO, Vol. 23, Issue 09, 091416, (August 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.091416

KEYWORDS: Tissue optics, Tissues, Optical properties, Skin, Collagen, Blood, Optical clearing, Optical coherence tomography, Optical testing, Scattering

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Proceedings Article | 26 April 2018 Paper

Investigation of change of tumor optical properties after laser-induced plasmon-resonant photothermal treatment of transplanted tumors in rats

Vadim Genin, Elina Genina, Alla Bucharskaya, Valery Tuchin, Nikolay Khlebtsov, Georgy Terentyuk, Alexey Bashkatov

Proceedings Volume 10716, 107160Z (2018) https://doi.org/10.1117/12.2315213

KEYWORDS: Tumors, Tissues, Scattering, Laser scattering, Nanoparticles, Absorption, Skin, Optical properties, Gold, Cancer

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Proceedings Article | 15 July 2015 Paper

Luminescence monitoring of particle delivery into rat skin in vivo

E. Volkova, I. Yanina, E. Genina, L. Dolotov, A. Bashkatov, V. Genin, J. Konyukhova, A. Popov, M. Kozintseva, E. Speranskaya, M. Lomova, G. Terentyuk, A. Bucharskaya, N. Navolokin, I. Goryacheva, V. Kochubey, D. Gorin, V. Tuchin, G. Sukhorukov

Proceedings Volume 9537, 95371P (2015) https://doi.org/10.1117/12.2183718

KEYWORDS: Skin, Luminescence, Nanoparticles, Tissues, Particles, Upconversion, In vivo imaging, Optical coherence tomography, Confocal microscopy, Tissue optics

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Proceedings Article | 19 March 2015 Paper

Measurement of diffusion coefficient of propylene glycol in skin tissue

Vadim Genin, Alexey Bashkatov, Elina Genina, Valery Tuchin

Proceedings Volume 9448, 94480E (2015) https://doi.org/10.1117/12.2180052

KEYWORDS: Skin, Tissues, Diffusion, Transmittance, Collimation, Tissue optics, Optical clearing, Refractive index, Liquids, Collagen

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