Interferometric diffuse correlation spectroscopy (iDCS) is an emerging technique that enables high quality measurements of cerebral blood flow. By including a reference arm in the optical setup, the SNR of the measured signals are improved relative to traditional DCS. We report here an expansion of our previously demonstrated 1064 nm single channel line scan camera based iDCS system to a multi-source, multiple detection channel approach to enable imaging of the brain perfusion response to functional activation. We confirm the ability to image multiple detectors on a single camera with minimal cross-talk using phantom experiments and show initial functional imaging results.
We developed combined diffuse reflectance spectroscopy – near-infrared diffuse correlation spectroscopy system. Cuff occlusion test, blood phantom test and test with anesthetic agents in a rat model were conducted for system verification. When the result of system verification follows the expected change in hemoglobin concentration change and the result of test with anesthetic agents shows effect of agents, then we can say that this combined system can be used for monitoring depth of anesthesia. This verified system can be used as the system for establishment of brain disease biomarker under anesthesia state.
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