Dr. Even Angell-Petersen Profile

Dr. Even Angell-Petersen

at Axis-Shield POC AS

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Publications (8)

Proceedings Article | 23 February 2009 Paper

Photochemical internalization enhances the efficacy of bleomycin in malignant glioma cells

Steen Madsen, Joseph Blickenstaff, Van Vo, Even Angell-Petersen, Henry Hirschberg

Proceedings Volume 7161, 716132 (2009) https://doi.org/10.1117/12.810097

KEYWORDS: Photodynamic therapy, Brain, Macromolecules, In vitro testing, Blood brain barrier, Toxicity, Tumors, Cancer, Chlorine, Proteins

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Proceedings Article | 23 March 2007 Paper

Increased brain edema following 5-aminolevulinic acid mediated photodynamic in normal and tumor bearing rats

Henry Hirschberg, Even Angell-Petersen, Signe Spetalen, Marlon Mathews, Steen Madsen

Proceedings Volume 6424, 64242B (2007) https://doi.org/10.1117/12.705439

KEYWORDS: Tumors, Brain, Photodynamic therapy, Blood brain barrier, Magnetic resonance imaging, Tissues, Neuroimaging, Distance measurement, Luminescence, Skin

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Introduction: Failure of treatment for high grade gliomas is usually due to local recurrence at the site of surgical resection indicating that a more aggressive form of local therapy, such as PDT, could be of benefit. PDT causes damage to both tumor cells as well as cerebral blood vessels leading to degradation of the blood brain barrier with subsequent increase of brain edema. The increase in brain edema following ALA-PDT was evaluated in terms of animal survival, histopatological changes in normal brain and tumor tissue and MRI scanning. The effect of steroid treatment, to reduce post-treatment PDT induced edema, was also examined. Methods:Tumors were established in the brains of inbred BD-IX and Fisher rats. At various times following tumor induction the animals were injected with ALA ip. and four hours later light treatment at escalating fluences and fluence rates were given. Nontumor bearing control animals were also exposed to ALA-PDT in a similar manner to evaluate damage to normal brain and degree of blood brain barrier (BBB) disruption. Results: Despite a very low level of PpIX production in normal brain, with a 200:1 tumor to normal tissue selectivity ratio measured at a distance of 2 mm from the tumor border, many animals succumbed shortly after treatment. A total radiant energy of 54 J to non-tumor bearing animals resulted in 50% mortality within 5 days of treatment. Treatment of tumor bearing animals with moderate fluence levels produced similar brain edema compared to higher fluence levels. ALA PDT in nontumor bearing animals produced edema that was light dose dependent. PDT appeared to open the BBB for a period of 24-48 hrs after which it was restored. The addition of post operative steroid treatment reduced the incident of post treatment morbidity and mortality. Conclusions: T2 and contrast enhanced T1 MRI scanning proved to be a highly effective and non-evasive modality in following the development of the edema reaction and the degree and time course of BBB dysfunction thus allowing the use of fewer animals.

SPIE Journal Paper | 1 January 2007 Open Access

Determination of fluence rate and temperature distributions in the rat brain; implications for photodynamic therapy

Even Angell-Petersen, Henry Hirschberg, Steen Madsen

JBO, Vol. 12, Issue 01, 014003, (January 2007) https://doi.org/10.1117/12.10.1117/1.2709882

KEYWORDS: Brain, Tumors, Temperature metrology, Diffusion, Monte Carlo methods, Scattering, Absorption, Photodynamic therapy, Light scattering, Optical properties

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Proceedings Article | 22 February 2006 Paper

ALA-PDT of glioma cell micro-clusters in BD-IX rat brain

Steen Madsen, Even Angell-Petersen, Signe Spetalen, Stephen Carper, Sarah Ziegler, Henry Hirschberg

Proceedings Volume 6078, 60782Y (2006) https://doi.org/10.1117/12.648969

KEYWORDS: Tumors, Brain, Photodynamic therapy, Blood brain barrier, Luminescence, Toxicity, Control systems, Tissues, Cancer, Lanthanum

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Proceedings Article | 25 April 2005 Paper

ALA-mediated photodynamic therapy of experimental malignant glioma in the BD-IX rat model

Henry Hirschberg, Even Angell-Petersen, Qian Peng, Chung-Ho Sun, Dag Sorensen, Steven Carper, Steen Madsen

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.591760

KEYWORDS: Tumors, Photodynamic therapy, Brain, Luminescence, Animal model studies, Tissues, In vitro testing, Tumor growth modeling, Cancer, Cell death

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Proceedings Article | 13 July 2004 Paper

Interstitial light application for photodynamic therapy in a rat brain tumor model

Even Angell-Petersen, Dag Sorensen, Steen Madsen, Henry Hirschberg

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.527417

KEYWORDS: Brain, Photodynamic therapy, Tumors, Scattering, Animal model studies, Monte Carlo methods, Diffusion, Absorption, Light scattering, Tissue optics

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Proceedings Article | 13 July 2004 Paper

Repetitive 5-aminolevulinic acid mediated photodynamic therapy of rat glioma

Henry Hirschberg, Steen Madsen, Even Angell-Petersen, Qian Peng, Mouldy Sioud, Chung-Ho Sun, Dag Sorensen

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.527395

KEYWORDS: Tumors, Photodynamic therapy, Brain, Tissues, Animal model studies, In vitro testing, Luminescence, Tissue optics, In vivo imaging, OSLO

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Proceedings Article | 3 February 1999 Paper

Cooperative effects of photosensitized cell killing

Jostein Dahle, Even Angel-Petersen, Saulius Bagdonas, Harald Steen, Johan Moan

Proceedings Volume 3563, (1999) https://doi.org/10.1117/12.339127

KEYWORDS: Cell death, Oxygen, Mathematical modeling, Biology, Plasma, Atmospheric modeling, Molybdenum, Luminescence, Computer simulations, Signal processing

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Showing 5 of 8 publications

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