Mr. Richard Klemm Profile

Richard Klemm

at microfluidic ChipShop GmbH

SPIE Involvement:

Author

Publications (25)

Proceedings Article | 30 May 2022 Presentation

Open microfluidic point-of-care diagnostic platform with freely configurable detection unit

Claudia Gärtner, Richard Klemm, Christian Moche, Nadine Hlawatsch, Holger Becker

Proceedings Volume PC12145, PC121450B (2022) https://doi.org/10.1117/12.2630859

KEYWORDS: Microfluidics, Diagnostics, Point-of-care devices, Standards development, Sensors, Luminescence, Liquids, Fluorescence spectroscopy, Chemical elements, Ultrasonography

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An open microfluidic point-of-care diagnostic (POC) platform will be presented that not only combines the ability to carry out various kinds of immunological, molecular or clinical chemistry tests at the point-of-care, allows for different sample types and can be used with a variety of detection technologies but in particular serves as open platform for users to integrate their own assays. The key advantages are as follows: 1) A standardized microfluidic cartridge architecture, with a common footprint, defined areas for functions allows for a toolbox-like development of a whole family of cartridges all using the same manufacturing tool and validated modules. 2) This finds its correspondence in the instrument which runs the cartridges. Standard footprint and common locations for functional elements makes the instrument versatile and able to run a variety of different assays in one instrument or allows for a rapid adaptation to new assays. 3) From an assay developer standpoint, such platforms with a proven system architecture provide a convenient pathway towards a simplified regulatory approval. On the presented platform, we have implemented a variety of assays, molecular diagnostics assays for infectious diseases. In case of these assays, the preferred detection method uses fluorescence. For immunoassays, colorimetric measurements with a simpler camera system are possible. In addition, the system also allows for the integration of sensors for detection. All cartridges include the complete assay flow from sample introduction to read-out. This includes all sample-preparation steps such as sample homogenization, sample lysis and nucleic acid extraction and concentration. In addition, all reagents required are embedded in the cartridge, either in liquid form or as dried reagents in dedicated locations. Overall, this platform allows especially small and medium-sized diagnostic companies and initiatives a rapid transition from bench to the market at a reasonable cost, significantly less compared to an ab-initio development.

Proceedings Article | 21 February 2020 Presentation + Paper

Kombispec: a microfluidics-based system for the fast on-site analytics in food production

Sebastian Schattschneider, Juliane Gottwald, Mareike Reichel, Jörg Schenk, Richard Klemm, Holger Becker, Claudia Gärtner

Proceedings Volume 11235, 112350O (2020) https://doi.org/10.1117/12.2552176

KEYWORDS: Microfluidics, Luminescence, Analytics, Proteins, Pathogens, Signal detection, Molecules, Contamination, Statistical analysis, Adsorption

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Proceedings Article | 14 March 2018 Presentation

Lab-on-a-chip analyzer for zoonotic pathogens in remotely-controlled robotic air and ground vehicles (Conference Presentation)

Holger Becker, Richard Klemm

Proceedings Volume 10491, 104910L (2018) https://doi.org/10.1117/12.2297105

KEYWORDS: Lab on a chip, Pathogens, Robotics, Surveillance, Biological and chemical sensing, Control systems, Liquids, Molecular biology, Bacteria, Biological weapons

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Proceedings Article | 18 March 2016 Presentation + Paper

Modular microfluidic cartridge-based universal diagnostic system for global health applications

Holger Becker, Richard Klemm, William Dietze, Wallace White, Nadine Hlawatsch, Susanne Freyberg, Christian Moche, Peter Dailey, Claudia Gärtner

Proceedings Volume 9705, 970514 (2016) https://doi.org/10.1117/12.2217892

KEYWORDS: Microfluidics, Diagnostics, Lab on a chip, Point-of-care devices, Polymers, Microfabrication, Chemistry, Diagnostic tests, Liquids, Chemical elements, Liver, Interfaces, Computer aided design, Blood, Manufacturing

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Proceedings Article | 2 June 2015 Paper

Multisense chip: continuously working air monitoring system: An integrated system for the detection of airborne biological pathogens on molecular and immunological level

Claudia Gärtner, Holger Becker, Nadine Hlawatsch, Richard Klemm, Sebastian Schattschneider, Christian Moche

Proceedings Volume 9455, 94550B (2015) https://doi.org/10.1117/12.2178923

KEYWORDS: Pathogens, Biological detection systems, System integration, Lab on a chip, Biological research, Molecular biology, Microfluidics, Bacteria, Liquids, Control systems

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Proceedings Article | 13 May 2015 Paper

Lab-on-a-chip enabled HLA diagnostic: combined sample preparation and real time PCR for HLA-B57 diagnosis

Claudia Gärtner, Holger Becker, Nadine Hlawatsch, Richard Klemm, Christian Moche, Sebastian Schattschneider, Rainer Frank, Andreas Willems

Proceedings Volume 9490, 94900F (2015) https://doi.org/10.1117/12.2178897

KEYWORDS: Blood, Microfluidics, Lab on a chip, Magnetism, Diagnostics, Point-of-care devices, Statistical analysis, Particles, Defense and security, Luminescence

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Proceedings Article | 5 March 2015 Paper

Integrated microfluidic system with automatic sampling for permanent molecular and antigen-based detection of CBRNE-related pathogens

Holger Becker, Sebastian Schattschneider, Richard Klemm, Nadine Hlawatsch, Claudia Gärtner

Proceedings Volume 9320, 93200X (2015) https://doi.org/10.1117/12.2077191

KEYWORDS: Microfluidics, Pathogens, System integration, Luminescence, Chemical elements, Liquids, Statistical analysis, Biological research, Molecular biology, Fluorescence spectroscopy

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Proceedings Article | 5 June 2014 Paper

Portable capillary electrophoresis-system for on-site food analysis with lab-on-a-chip based contactless conductivity detection

Claudia Gärtner, René Sewart, Richard Klemm, Holger Becker

Proceedings Volume 9112, 911211 (2014) https://doi.org/10.1117/12.2050249

KEYWORDS: Electrodes, Lithium, Capillaries, Blood, Statistical analysis, Microfluidics, Ions, Calibration, Lab on a chip, Liquids

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Proceedings Article | 29 May 2014 Paper

A microfluidic platform with integrated arrays for immunologic assays for biological pathogen detection

Richard Klemm, Holger Becker, Nadine Hlawatsch, Sandra Julich, Peter Miethe, Christian Moche, Sebastian Schattschneider, Herbert Tomaso, Claudia Gärtner

Proceedings Volume 9073, 907311 (2014) https://doi.org/10.1117/12.2050269

KEYWORDS: Microfluidics, Pathogens, Fluorescence spectroscopy, Lab on a chip, Interfaces, Control systems, Liquids, Contamination, Point-of-care devices, Imaging systems

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Proceedings Article | 22 May 2014 Paper

Lab-on-a-chip PCR: real time PCR in miniaturized format for HLA diagnostics

Claudia Gaertner, Holger Becker, Nadine Hlawatsch, Richard Klemm, Christian Moche, René Sewart, Rainer Frank, Andreas Willems

Proceedings Volume 9107, 91070O (2014) https://doi.org/10.1117/12.2050233

KEYWORDS: Lab on a chip, Blood, Biological research, Statistical analysis, Diagnostics, Microfluidics, Luminescence, Chemical elements, Magnetism, Transplantation

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Proceedings Article | 6 March 2014 Paper

Real-time PCR in microfluidic devices

Holger Becker, Nadine Hlawatsch, Richard Klemm, Christian Moche, Thomas Hansen-Hagge, Claudia Gärtner

Proceedings Volume 8976, 89760Z (2014) https://doi.org/10.1117/12.2037241

KEYWORDS: Microfluidics, Luminescence, Liquids, Lab on a chip, Genetics, Polymers, Diagnostics, Cameras, Absorption, Heat treatments

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Proceedings Article | 29 May 2013 Paper

Development of a versatile lab-on-a-chip enzyme assay platform for pathogen detection in CBRNE scenarios

Richard Klemm, Sebastian Schattschneider, Tobias Jahn, Nadine Hlawatsch, Sandra Julich, Holger Becker, Claudia Gärtner

Proceedings Volume 8725, 87252K (2013) https://doi.org/10.1117/12.2018051

KEYWORDS: Pathogens, Microfluidics, Interfaces, Proteins, Lab on a chip, Weapons of mass destruction, Liquids, Contamination, Actuators, Organisms

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Proceedings Article | 9 March 2013 Paper

Multi-hybrid instrumentations with smartphones and smartpads for innovative in-field and POC diagnostics

Dietrich Hofmann, Paul-Gerald Dittrich, Claudia Gärtner, Richard Klemm

Proceedings Volume 8615, 861508 (2013) https://doi.org/10.1117/12.2005885

KEYWORDS: Diagnostics, Microfluidics, Biology, Medicine, Microscopes, Point-of-care devices, Surgery, Biological research, Sensors, Photons

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Proceedings Article | 16 May 2012 Paper

Lab-on-a-chip platforms from sample preparation via continuous-flow PCR to an ultrafast detection of B-agents

Richard Klemm, Holger Becker, Nadine Hlawatsch, Claudia Gärtner

Proceedings Volume 8367, 83670D (2012) https://doi.org/10.1117/12.920790

KEYWORDS: Pathogens, Microfluidics, Integration, Magnetism, Lab on a chip, Fluorescence spectroscopy, Ultrafast phenomena, Manufacturing, Liquids, Target detection

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Proceedings Article | 5 May 2012 Paper

A microfluidic toolbox approach to CBRNE sensing

Claudia Gärtner, Richard Klemm, Nadine Hlawatsch, Holger Becker

Proceedings Volume 8358, 83581G (2012) https://doi.org/10.1117/12.920802

KEYWORDS: Microfluidics, Biological research, Blood, Liquids, Chemical analysis, Plasma, Weapons of mass destruction, Statistical analysis, Interfaces, Magnetism

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Proceedings Article | 14 February 2012 Paper

Magnetic particle-based sample-prep and valveing in microfluidic devices

Richard Klemm, Nadine Hlawatsch, Thomas Hansen-Hagge, Holger Becker, Claudia Gärtner

Proceedings Volume 8251, 825108 (2012) https://doi.org/10.1117/12.910179

KEYWORDS: Magnetism, Particles, Microfluidics, Liquids, Bacteria, Chemical elements, Lab on a chip, Integration, Fluid dynamics, Control systems

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Proceedings Article | 14 February 2012 Paper

A lab-on-a-chip system for the development of complex assays using modular microfluidic components

Nadine Hlawatsch, Richard Klemm, Cornelia Carstens, Thomas Brandstëtter, Holger Becker, Rudi Elbracht, Claudia Gärtner

Proceedings Volume 8251, 82510D (2012) https://doi.org/10.1117/12.910269

KEYWORDS: Microfluidics, Bacteria, Magnetism, Blood, Interfaces, Luminescence, Lab on a chip, Diagnostics, Integration, Molecules

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Proceedings Article | 15 February 2011 Paper

A sample-in result-out lab-on-a-chip device: from prototype to mass fabrication

Richard Klemm, Nadine Hlawatsch, Claudia Gärtner, Mathieu Jung, Julian Höth, Ciara O'Sullivan, Holger Becker

Proceedings Volume 7929, 79290D (2011) https://doi.org/10.1117/12.874907

KEYWORDS: Microfluidics, Manufacturing, Diagnostics, Interfaces, Prototyping, Liquids, Blood, Lab on a chip, Point-of-care devices, Genetics

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Proceedings Article | 15 February 2011 Paper

From sample-to-answer: integrated genotyping and immunological analysis microfluidic platforms for the diagnostic and treatment of coeliac disease

M. Jung, J. Höth, J. Erwes, D. Latta, X. Strobach, T. Hansen-Hagge, R. Klemm, C. Gärtner, T. Demiris, C. O'Sullivan, M. Ritzi-Lehnert, K. Drese

Proceedings Volume 7929, 79290E (2011) https://doi.org/10.1117/12.875314

KEYWORDS: Microfluidics, Blood, Microsystems, Diagnostics, Statistical analysis, Plasma, Interfaces, Genetics, Point-of-care devices, Polymers

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Proceedings Article | 11 February 2011 Paper

Integrated lab-on-a-chip: a combined sample preparation and PCR system as an ultrafast analytical tool for pathogen detection

Holger Becker, Nadine Hlawatsch, Richard Klemm, Claudia Gärtner

Proceedings Volume 7929, 792903 (2011) https://doi.org/10.1117/12.874551

KEYWORDS: Pathogens, Microfluidics, Manufacturing, Lab on a chip, Control systems, Statistical analysis, Standards development, Bacteria, Luminescence, Magnetism

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Proceedings Article | 8 May 2009 Paper

Lab-on-a-chip PCR in continuous flow: an ultrafast analytical tool for B-agents

Claudia Gärtner, Holger Becker, Thomas Clemens, Richard Klemm, Matthias Klotz, Nadine Hlawatsch

Proceedings Volume 7304, 73040G (2009) https://doi.org/10.1117/12.819429

KEYWORDS: Ultrafast phenomena, Biological research, Statistical analysis, Microfluidics, Liquids, Lab on a chip, Polymers, Blood, Bacteria, Viruses

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Proceedings Article | 28 April 2009 Paper

Portable integrated capillary-electrophoresis system using disposable polymer chips with capacitively coupled contactless conductivity detection for on-site analysis of foodstuff

Claudia Gärtner, Werner Hoffmann, Horst Demattio, Thomas Clemens, Matthias Klotz, Richard Klemm, Holger Becker

Proceedings Volume 7315, 731505 (2009) https://doi.org/10.1117/12.820316

KEYWORDS: Electrodes, Polymethylmethacrylate, System integration, Polymers, Statistical analysis, Metals, Sensors, Electronics, Manufacturing, Ions

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Proceedings Article | 25 April 2009 Paper

SmartHEALTH: a microfluidic multisensor platform for POC cancer diagnostics

Claudia Gärtner, Holger Becker, Cornelia Carstens, Frithjof von Germar, Klaus Stefan Drese, Alex Fragoso, Rainer Gransee, Andreas Guber, Dirk Herrmann, Nadine Hlawatsch, Richard Klemm, Daniel Latta, Ciara O'Sullivan, Jesus Ruano-Lopez

Proceedings Volume 7313, 73130B (2009) https://doi.org/10.1117/12.820311

KEYWORDS: Sensors, Microfluidics, Liquids, Diagnostics, Interfaces, Sensor technology, Plasma, Cancer, Polymers, Standards development

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Proceedings Article | 24 February 2009 Paper

Continuous-flow PCR using segmented flow and integrating sample preparation

Holger Becker, Nadine Hlawatsch, Cornelia Carstens, Richard Klemm, Claudia Gärtner

Proceedings Volume 7207, 72070J (2009) https://doi.org/10.1117/12.809980

KEYWORDS: Microfluidics, Genetics, Diagnostics, Minerals, Polymers, Magnetism, Diagnostic tests, Statistical analysis, Microfabrication, Biological research

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Proceedings Article | 13 February 2008 Paper

Portable CE system with contactless conductivity detection in an injection molded polymer chip for on-site food analysis

Holger Becker, Holger Mühlberger, Werner Hoffmann, Thomas Clemens, Richard Klemm, Claudia Gärtner

Proceedings Volume 6886, 68860C (2008) https://doi.org/10.1117/12.773579

KEYWORDS: Electrodes, Signal detection, Minerals, Power supplies, Polymers, Capillaries, Ions, Electronics, Polymethylmethacrylate, Thin films

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Showing 5 of 25 publications

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