Prof. Shang Wang Profile

Prof. Shang Wang

Assistant Professor at Stevens Institute of Technology

SPIE Involvement:

Author

Publications (56)

Proceedings Article | 13 March 2024 Presentation

Dynamic OCT for in vivo cilia metachronal wave analysis in the mouse fallopian tube

Tian Xia, Shang Wang, Irina Larina

Proceedings Volume PC12841, PC1284102 (2024) https://doi.org/10.1117/12.3006504

KEYWORDS: Optical coherence tomography, In vivo imaging, Fallopian tube, Visualization, Reproductive system, Wave propagation, Tissues, Pathology, Mouse models, Genetics

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Proceedings Article | 13 March 2024 Presentation

Three-dimensional velocimetry based on a single OCT volume containing double B-scans for assessment of embryo movement in the mouse oviduct in vivo

Tianqi Fang, Huan Han, Jingyu Sun, Shang Wang

Proceedings Volume PC12841, PC1284101 (2024) https://doi.org/10.1117/12.3010141

KEYWORDS: Optical coherence tomography, Velocimetry, Particles, In vivo imaging, 3D image processing, Tissues, Velocity measurements, Stereoscopy, Motion analysis, Fallopian tube

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Proceedings Article | 13 March 2024 Presentation

Imaging of nanoparticle-labeled live cells in 3D culture with photothermal optical coherence tomography (OCT)

Jingyu Sun, Tianqi Fang, Hongjun Wang, Shang Wang

Proceedings Volume PC12841, PC1284109 (2024) https://doi.org/10.1117/12.3006228

KEYWORDS: Biological imaging, 3D image processing, Live cell imaging, Optical coherence tomography, 3D acquisition, Stereoscopy, Scattering media, Modulation, Fluorescence imaging, Tissues

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Proceedings Article | 13 March 2024 Presentation

Efficient 4D reconstruction of the beating embryonic heart with a single, linearly scanned, densely sampled 3D OCT image

Andre Faubert, Shang Wang

Proceedings Volume 12819, 128190N (2024) https://doi.org/10.1117/12.3008576

KEYWORDS: Heart, Optical coherence tomography, 3D image reconstruction, 3D scanning, 3D image processing, Medical image reconstruction, Stereoscopy, 3D acquisition, Hemodynamics, Animal model studies

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Proceedings Article | 17 March 2023 Presentation

Hollow porous platinum-based nanocomposite for combined tumor therapy (Conference Presentation)

Jingyu Sun, Shang Wang, Hongjun Wang

Proceedings Volume PC12395, PC123950B (2023) https://doi.org/10.1117/12.2651012

KEYWORDS: Tumors, Platinum, Nanostructures, Nanocomposites, Nanoparticles, Absorption, Tissues, Solids, Silver, Scattering

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Proceedings Article | 17 March 2023 Presentation

Longitudinal high-resolution 4D imaging of the mouse embryonic heart development with optical coherence tomography

Andre Faubert, Irina Larina, Shang Wang

Proceedings Volume PC12355, PC123550C (2023) https://doi.org/10.1117/12.2649559

KEYWORDS: Heart, Optical coherence tomography, Mouse models, Confocal microscopy, Wave propagation, Visualization, Microscopy, Light emitting diodes, Hemodynamics, Coherence (optics)

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Proceedings Article | 7 March 2023 Presentation + Paper

In vivo dynamic quantitative imaging of cilia metachronal wave in mouse fallopian tube with optical coherence tomography

Tian Xia, Shang Wang, Irina Larina

Proceedings Volume 12378, 1237802 (2023) https://doi.org/10.1117/12.2656886

KEYWORDS: Optical coherence tomography, Fallopian tube, In vivo imaging, Imaging systems, Wave propagation, Visualization, Tissues, Statistical analysis, Biological imaging, Windows

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Proceedings Article | 7 March 2023 Presentation

A method for efficient 4D reconstruction of cardio-and hemodynamics in the embryonic mouse using OCT

Andre Faubert, Irina Larina, Shang Wang

Proceedings Volume PC12378, PC123780A (2023) https://doi.org/10.1117/12.2649349

KEYWORDS: Optical coherence tomography, Heart, Hemodynamics, 3D acquisition, Visualization, Luminescence, Data acquisition, Confocal microscopy, Automatic alignment, 3D image processing

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Proceedings Article | 2 March 2022 Paper

Tracking spermatozoa movement toward the egg with functional optical coherence tomography

Tian Xia, Kohei Umezu, Shang Wang, Irina Larina

Proceedings Volume 11959, 1195902 (2022) https://doi.org/10.1117/12.2608265

KEYWORDS: Optical coherence tomography, In vivo imaging, Visualization, Optical tracking, Speckle, Signal detection, In vitro testing, Imaging systems, Control systems, Microscopy

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Proceedings Article | 2 March 2022 Presentation

Dynamic volumetric imaging of ovulated egg transport to the fallopian tube with optical coherence tomography

Kohei Umezu, Shang Wang, Irina Larina

Proceedings Volume PC11959, PC119590H (2022) https://doi.org/10.1117/12.2610328

KEYWORDS: Optical coherence tomography, Fallopian tube, Ovary, In vivo imaging, Tissues, Pathology, Mouse models, Genetics

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Proceedings Article | 2 March 2022 Presentation

Quantitative OCT analysis of sperm hyperactivation state in mouse fallopian tube

Zheng-Chen Yao, Shang Wang, Irina Larina

Proceedings Volume PC11959, PC119590I (2022) https://doi.org/10.1117/12.2610364

KEYWORDS: Optical coherence tomography, In vivo imaging, Fallopian tube, Visualization, Velocity measurements, Tissues, Optical tracking, In vitro testing

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SPIE Journal Paper | 5 August 2020 Open Access

Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart

Shang Wang, Irina Larina

JBO, Vol. 25, Issue 08, 086001, (August 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.8.086001

KEYWORDS: Heart, Blood circulation, Resistance, Optical coherence tomography, Video, Blood, Hemodynamics, Doppler effect, Imaging systems

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Significance: Understanding how the valveless embryonic heart pumps blood is essential to elucidate biomechanical cues regulating cardiogenesis, which is important for the advancement of congenital heart defects research. However, methods capable of embryonic cardiac pumping analysis remain limited, and assessing this highly dynamic process in mammalian embryos is challenging. New approaches are critically needed to address this hurdle. Aim: We report an imaging-based approach for functional assessment of localized pumping dynamics in the early tubular embryonic mouse heart. Approach: Four-dimensional optical coherence tomography was used to obtain structural and Doppler hemodynamic imaging of the beating heart in live mouse embryos at embryonic day 9.25. The pumping assessment was performed based on the volumetric blood flow rate, flow resistance within the heart tube, and pressure gradient induced by heart wall movements. The relation between the blood flow, the pressure gradient, and the resistance to flow were evaluated through temporal analyses and Granger causality test. Results: In the ventricles, our method revealed connections between the temporal profiles of pressure gradient and volumetric blood flow rate. Statistically significant causal relation from the pressure gradient to the blood flow was demonstrated. Our analysis also suggests that cardiac pumping in the early ventricles is a combination of suction and pushing. In contrast, in the outflow tract, where the conduction wave is slower than the blood flow, we did not find significant causal relation from pressure to flow, suggesting that, different from ventricular regions, the local active contraction of the outflow tract is unlikely to drive the flow in that region. Conclusions: We present an imaging-based approach that enables localized assessment of pumping dynamics in the mouse tubular embryonic heart. This method creates a new opportunity for functional analysis of the pumping mechanism underlying the developing mammalian heart at early stages and could be useful for studying biomechanical changes in mutant embryonic hearts that model congenital heart defects.

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Proceedings Article | 9 March 2020 Presentation

Biomechanical analysis of the embryonic mouse heart by optogenetic control (Conference Presentation)

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 11215, 112150J (2020) https://doi.org/10.1117/12.2548853

KEYWORDS: Heart, Optogenetics, Biological research, Harmonic generation, Collagen, Modulators, In vivo imaging, Integration, Pulsed laser operation, Optical coherence tomography

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Proceedings Article | 24 February 2020 Paper

Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism

Shang Wang, Riana Syed, Irina Larina

Proceedings Volume 11239, 112390A (2020) https://doi.org/10.1117/12.2553962

KEYWORDS: Heart, Blood circulation, Optical coherence tomography, Hemodynamics, Doppler effect, Imaging systems, Biomedical engineering, Physiology

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Proceedings Article | 7 March 2019 Presentation

Optical coherence tomography, optogenetic control, and second harmonic generation microscopy for investigation of embryonic cardiodynamics (Conference Presentation)

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 10855, 108550L (2019) https://doi.org/10.1117/12.2514608

KEYWORDS: Heart, Optogenetics, Optical coherence tomography, Harmonic generation, Microscopy, In vivo imaging, Coherence imaging, Collagen, Modulators, 3D image processing

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Proceedings Article | 4 March 2019 Presentation

An analytical model of laser-induced dynamic thermoelastic deformation of the viscoelastic half-space (Conference Presentation)

Salavat Aglyamov, Susobhan Das, Chih -Hao Liu, Shang Wang, Alexander Schill, Kirill Larin

Proceedings Volume 10880, 108800E (2019) https://doi.org/10.1117/12.2506194

KEYWORDS: Tissues, Biological research, Elastography, Pulsed laser operation, Signal attenuation, Laser applications, Optical coherence tomography, Acoustics, Absorption, Natural surfaces

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Proceedings Article | 4 March 2019 Presentation

In vivo imaging of mammalian reproductive events with functional optical coherence tomography (Conference Presentation)

Shang Wang, Emma Moore, Riana Syed, Irina Larina

Proceedings Volume 10877, 108770G (2019) https://doi.org/10.1117/12.2514609

KEYWORDS: Optical coherence tomography, In vivo imaging, 3D image processing, In vitro testing, Tissues, Visualization, Biology

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Proceedings Article | 22 February 2019 Paper

Optical coherence elastography reveals the changes in cardiac tissue biomechanical properties after myocardial infarction in a mouse model

Manmohan Singh, Shang Wang, Chih-Hao Liu, John Leach, Justin Rippy, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 10867, 108672B (2019) https://doi.org/10.1117/12.2511524

KEYWORDS: Tissues, Tissue optics, Anisotropy, Coherence (optics), Elastography, Heart, Mouse models, Biological research, Wave propagation, Therapeutics

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Proceedings Article | 21 February 2019 Paper

Assessment of the biomechanical changes in cardiac tissue after myocardial infarction with optical coherence elastography

Manmohan Singh, Shang Wang, Chih-Hao Liu, John Leach, Justin Rippy, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 10880, 1088003 (2019) https://doi.org/10.1117/12.2510762

KEYWORDS: Tissues, Anisotropy, Tissue optics, Heart, Elastography, Therapeutics, Coherence (optics), Wave propagation, Biological research, Molecular mechanisms

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Proceedings Article | 26 February 2018 Presentation + Paper

Functional optical coherence tomography for live dynamic analysis of mouse embryonic cardiogenesis

Shang Wang, Andrew Lopez, Irina Larina

Proceedings Volume 10493, 104930C (2018) https://doi.org/10.1117/12.2292106

KEYWORDS: Optical coherence tomography, Heart, Blood circulation, Speckle, Doppler effect, Wave propagation, Blood, Speckle imaging, Imaging systems, Doppler tomography

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Blood flow, heart contraction, and tissue stiffness are important regulators of cardiac morphogenesis and function during embryonic development. Defining how these factors are integrated is critically important to advance prevention, diagnostics, and treatment of congenital heart defects. Mammalian embryonic development is taking place deep within the female body, which makes cardiodynamic imaging and analysis during early developmental stages in humans inaccessible. With thousands of mutant lines available and well-established genetic manipulation tools, mouse is a great model to understand how biomechanical factors are integrated with molecular pathways to regulate cardiac function and development. Dynamic imaging and quantitative analysis of the biomechanics of live mouse embryos have become increasingly important, which demands continuous advancements in imaging techniques and live assessment approaches. This has been one of the major drives to keep pushing the frontier of embryonic imaging for better resolution, higher speed, deeper penetration, and more diverse and effective contrasts. Optical coherence tomography (OCT) has played a significant role in addressing such demands, and its features in non-labeling imaging, 3D capability, a large working distance, and various functional derivatives allow OCT to cover a number of specific applications in embryonic imaging. Recently, our group has made several technical improvements in using OCT to probe the biomechanical aspects of live developing mouse embryos at early stages. These include the direct volumetric structural and functional imaging of the cardiodynamics, four-dimensional quantitative Doppler imaging and analysis of the cardiac blood flow, and fourdimensional blood flow separation from the cardiac wall tissue in the beating embryonic heart. Here, we present a short review of these studies together with brief descriptions of the previous work that demonstrate OCT as a valuable and useful imaging tool for the research in developmental cardiology.

Proceedings Article | 7 February 2018 Presentation + Paper

Live dynamic analysis of mouse embryonic cardiogenesis with functional optical coherence tomography

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 10472, 104720S (2018) https://doi.org/10.1117/12.2292104

KEYWORDS: Heart, Optical coherence tomography, Collagen, Second-harmonic generation, Visualization, Tissues, Biological research

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Proceedings Article | 21 February 2017 Paper

Evaluation of dermal fillers with noncontact optical coherence elastography

Manmohan Singh, Shang Wang, Richard Yee, Zhaolong Han, Salavat Aglyamov, Kirill Larin

Proceedings Volume 10067, 1006714 (2017) https://doi.org/10.1117/12.2251544

KEYWORDS: Optical coherence tomography, Tissue optics, Elastography, Coherence (optics), Skin, Visualization, Ultrasonography, Magnetic resonance imaging, Transducers, Temporal resolution, Spatial resolution

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Proceedings Article | 8 February 2017 Presentation + Paper

Live dynamic analysis of the developing cardiovascular system in mice

Andrew Lopez, Shang Wang, Kirill Larin, Irina Larina

Proceedings Volume 10043, 100430Q (2017) https://doi.org/10.1117/12.2252694

KEYWORDS: Heart, Optical coherence tomography, Cardiovascular system, Blood circulation, Image processing, Computational modeling, 3D image processing, Optical imaging, Medicine, Tissues, Imaging systems, Doppler tomography, Biological research

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Proceedings Article | 6 February 2017 Paper

Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

Manmohan Singh, Shang Wang, Richard Yee, Zhaolong Han, Salavat Aglyamov, Kirill Larin

Proceedings Volume 10037, 100370W (2017) https://doi.org/10.1117/12.2251541

KEYWORDS: Optical coherence tomography, Skin, Coherence (optics), Elastography, Visualization, Tissue optics, Spatial resolution, 3D image processing, Blood vessels, Photonics, Tissues, Mirrors

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Proceedings Article | 15 March 2016 Presentation + Paper

A three dimensional solution for laser-induced thermoelastic deformation of the layered medium

Salavat Aglyamov, Shang Wang, Stanislav Emelianov, Kirill Larin

Proceedings Volume 9710, 971010 (2016) https://doi.org/10.1117/12.2213480

KEYWORDS: Laser tissue interaction, Tissue optics, Biomedical engineering, Laser development, 3D modeling, 3D image processing, Laser applications

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Proceedings Article | 9 March 2016 Paper

Live dynamic OCT imaging of cardiac structure and function in mouse embryos with 43 Hz direct volumetric data acquisition

Shang Wang, Manmohan Singh, Andrew Lopez, Chen Wu, Raksha Raghunathan, Alexander Schill, Jiasong Li, Kirill Larin, Irina Larina

Proceedings Volume 9716, 971603 (2016) https://doi.org/10.1117/12.2210751

KEYWORDS: Optical coherence tomography, Heart, Data acquisition, Functional imaging, Mode locking, Speckle, Doppler tomography, Blood circulation, Cardiovascular magnetic resonance imaging, Animal model studies, Ultrafast imaging, Imaging systems, Laser sources, Motion analysis, 3D image processing

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Proceedings Article | 9 March 2016 Presentation + Paper

Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping

Andrew Lopez, Shang Wang, Kirill Larin, Paul Overbeek, Irina Larina

Proceedings Volume 9716, 971609 (2016) https://doi.org/10.1117/12.2212452

KEYWORDS: Optical coherence tomography, 3D image processing, Optical imaging, Image processing, Visualization, Image resolution, Heart, Genetics, Physiology, Molecular imaging, Medicine, Analytical research, Mouse models, Imaging systems, Molecular biology, Biology

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Proceedings Article | 9 March 2016 Paper

Mechanical characterization of the mouse diaphragm with optical coherence elastography reveals fibrosis-related change of direction-dependent muscle tissue stiffness

Shang Wang, James Loehr, Irina Larina, George Rodney, Kirill Larin

Proceedings Volume 9710, 97100P (2016) https://doi.org/10.1117/12.2211160

KEYWORDS: Tissues, Elastography, Wave propagation, Coherence (optics), Optical coherence tomography, Tissue optics, Genetics, Natural surfaces, Optical fibers, Biological research, Neodymium

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Proceedings Article | 9 March 2016 Presentation + Paper

Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography

Jason Burton, Shang Wang, Richard Behringer, Irina Larina

Proceedings Volume 9716, 97160E (2016) https://doi.org/10.1117/12.2213202

KEYWORDS: Optical coherence tomography, Uterus, Ovary, In vivo imaging, Biology, Stereoscopy, 3D image processing, 3D modeling, Spatial resolution, Tissues, Confocal microscopy, Genetics

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Proceedings Article | 29 February 2016 Paper

Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo

Shang Wang, Jason Burton, Richard Behringer, Irina Larina

Proceedings Volume 9689, 96893R (2016) https://doi.org/10.1117/12.2210758

KEYWORDS: Optical coherence tomography, In vivo imaging, Functional imaging, Speckle, Microscopy, Breast, Reproductive system, Structural imaging, Tissues, Genetics, Imaging systems, Medicine, Mouse models

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SPIE Journal Paper | 21 September 2015 Open Access

Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant

Shang Wang, Andrew Lopez, Kirill Larin, Paul Overbeek, Irina Larina

JBO, Vol. 20, Issue 09, 090501, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.090501

KEYWORDS: Optical coherence tomography, Heart, Imaging systems, Statistical analysis, Visualization, 3D image processing, Medicine, Video, Blood circulation, Genetics

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Proceedings Article | 20 March 2015 Paper

Quantitative assessment of corneal biomechanical properties using optical coherence elastography and a modified Rayleigh Lamb-frequency model

Zhaolong Han, Salavat Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih-hao Liu, Michael Twa, Kirill Larin

Proceedings Volume 9307, 930719 (2015) https://doi.org/10.1117/12.2079542

KEYWORDS: Cornea, Phase velocity, Elastography, Coherence (optics), Geometrical optics, Optical coherence tomography, Tissues, Protactinium, Biological research, Wave propagation

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Proceedings Article | 20 March 2015 Paper

Three-dimensional mapping of corneal elasticity using optical coherence elastography

Manmohan Singh, Jiasong Li, Shang Wang, Srilatha Vantipalli, Michael Twa, Kirill Larin

Proceedings Volume 9307, 930718 (2015) https://doi.org/10.1117/12.2080066

KEYWORDS: Cornea, Elastography, Coherence (optics), Tissues, Wave propagation, Acoustics, Optical coherence tomography, Natural surfaces, Tissue optics, Collagen

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Proceedings Article | 12 March 2015 Paper

Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

Chen Wu, Zhaolong Han, Shang Wang, Jiasong Li, Manmohan Singh, Chih-hao Liu, Salavat Aglyamov, Stanislav Emelianov, Fabrice Manns, Kirill Larin

Proceedings Volume 9307, 930716 (2015) https://doi.org/10.1117/12.2079532

KEYWORDS: Ultrasonography, Crystals, Optical coherence tomography, Acoustics, Elastography, Eye, Crystallography, Coherence (optics), Transducers, Tissues

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Proceedings Article | 10 March 2015 Paper

Live dynamic imaging and analysis of developmental cardiac defects in mouse models with optical coherence tomography

Andrew Lopez, Shang Wang, Monica Garcia, Christian Valladolid, Kirill Larin, Irina Larina

Proceedings Volume 9334, 93340S (2015) https://doi.org/10.1117/12.2079951

KEYWORDS: Optical coherence tomography, Visualization, Mouse models, Image processing, 3D image reconstruction, Imaging systems, 3D acquisition, Carbon dioxide, Medicine, Molecular biology

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Proceedings Article | 10 March 2015 Paper

Dynamic imaging of preimplantation embryos in the murine oviduct

Jason Burton, Shang Wang, Irina Larina

Proceedings Volume 9334, 933409 (2015) https://doi.org/10.1117/12.2079913

KEYWORDS: Optical coherence tomography, Ovary, Uterus, Imaging systems, Visualization, Tissues, 3D modeling, 3D image processing, Medicine, Biology

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Proceedings Article | 6 March 2015 Paper

Noncontact depth-resolved micro-scale corneal elastography

Shang Wang, Kirill Larin

Proceedings Volume 9327, 932716 (2015) https://doi.org/10.1117/12.2076623

KEYWORDS: Cornea, Wave propagation, Elastography, Optical coherence tomography, Phase velocity, Imaging systems, Dispersion, Tissue optics, Ultrasonography, Tissues

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Proceedings Article | 6 March 2015 Paper

Noninvasive 3D elasticity mapping using phase-stabilized optical coherence elastography

Manmohan Singh, Jiasong Li, Shang Wang, Michael Twa, Kirill Larin

Proceedings Volume 9327, 932703 (2015) https://doi.org/10.1117/12.2078315

KEYWORDS: Tissues, Wave propagation, Elastography, Coherence (optics), Optical coherence tomography, Tissue optics, Cornea, Acoustics, Signal detection, Statistical analysis

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Proceedings Article | 6 March 2015 Paper

Quantitative shear wave imaging optical coherence tomography for noncontact mechanical characterization of myocardium

Shang Wang, Andrew Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 9327, 93270F (2015) https://doi.org/10.1117/12.2078376

KEYWORDS: Tissue optics, Tissues, Optical coherence tomography, Biomedical optics, Elastography, Coherence imaging, Coherence (optics), Imaging systems, Soft tissue optics, Heart

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Optical coherence elastography (OCE) is an emerging low-coherence imaging technique that provides noninvasive assessment of tissue biomechanics with high spatial resolution. Among various OCE methods, the capability of quantitative measurement of tissue elasticity is of great importance for tissue characterization and pathology detection across different samples. Here we report a quantitative OCE technique, termed quantitative shear wave imaging optical coherence tomography (Q-SWI-OCT), which enables noncontact measurement of tissue Young’s modulus based on the ultra-fast imaging of the shear wave propagation inside the sample. A focused air-puff device is used to interrogate the tissue with a low-pressure short-duration air stream that stimulates a localized displacement with the scale at micron level. The propagation of this tissue deformation in the form of shear wave is captured by a phase-sensitive OCT system running with the scan of the M-mode imaging over the path of the wave propagation. The temporal characteristics of the shear wave is quantified based on the cross-correlation of the tissue deformation profiles at all the measurement locations, and linear regression is utilized to fit the data plotted in the domain of time delay versus wave propagation distance. The wave group velocity is thus calculated, which results in the quantitative measurement of the Young’s modulus. As the feasibility demonstration, experiments are performed on tissuemimicking phantoms with different agar concentrations and the quantified elasticity values with Q-SWI-OCT agree well with the uniaxial compression tests. For functional characterization of myocardium with this OCE technique, we perform our pilot experiments on ex vivo mouse cardiac muscle tissues with two studies, including 1) elasticity difference of cardiac muscle under relaxation and contract conditions and 2) mechanical heterogeneity of the heart introduced by the muscle fiber orientation. Our results suggest the potential of using Q-SWI-OCT as an essential tool for nondestructive biomechanical evaluation of myocardium.

Proceedings Article | 6 March 2015 Paper

Quantitative assessment of the mechanical properties of tissue-mimicking agar phantoms by optical coherence elastography and numerical analyses

Zhaolong Han, Jiasong Li, Manmohan Singh, Chen Wu, Chih-Hao Liu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Narendran Sudheendran, Salavat Aglyamov, Michael Twa, Kirill Larin

Proceedings Volume 9327, 932710 (2015) https://doi.org/10.1117/12.2078466

KEYWORDS: Finite element methods, Tissues, Tissue optics, Elastography, Coherence (optics), Phase velocity, Natural surfaces, Numerical analysis, Data modeling, Spatial resolution

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Proceedings Article | 5 March 2015 Paper

Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

Chih-Hao Liu, Manmohan Singh, Jiasong Li, Zhaolong Han, Chen Wu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Valery Zakharov, Emil Sobol, Valery Tuchin, Michael Twa, Kirill Larin

Proceedings Volume 9322, 93220B (2015) https://doi.org/10.1117/12.2079854

KEYWORDS: Cartilage, Optical coherence tomography, Tissue optics, Glucose, Optical clearing, Tissues, Biomedical optics, Elastography, Soft tissue optics, Coherence (optics)

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Proceedings Article | 2 March 2015 Paper

Probing myocardium biomechanics using quantitative optical coherence elastography

Shang Wang, Andrew Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 9312, 93121Z (2015) https://doi.org/10.1117/12.2078390

KEYWORDS: Tissue optics, Optical coherence tomography, Tissues, Biomedical optics, Coherence (optics), Soft tissue optics, Elastography, Wave propagation, Heart, Coherence imaging

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SPIE Journal Paper | 3 February 2015 Open Access

Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation

Zhaolong Han, Salavat Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih-hao Liu, Michael Twa, Kirill Larin

JBO, Vol. 20, Issue 02, 020501, (February 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.2.020501

KEYWORDS: Cornea, Elastography, Coherence (optics), Phase velocity, Geometrical optics, Tissues, Protactinium, Optical scanning systems, Natural surfaces, Biological research

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SPIE Journal Paper | 12 January 2015 Open Access

Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

Saba Syed, Andrew Coughlin, Monica Garcia, Shang Wang, Jennifer West, Kirill Larin, Irina Larina

JBO, Vol. 20, Issue 05, 051020, (January 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.051020

KEYWORDS: Optical coherence tomography, Gold, Silica, Imaging systems, Blood, 3D image processing, Spatial resolution, Heart, Blood vessels, Stereoscopy

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Proceedings Article | 4 March 2014 Paper

Combining optical coherence tomography with acoustic radiation force for depth-dependent biomechanics of crystalline lens

Shang Wang, Salavat Aglyamov, Andrei Karpiouk, Jiasong Li, Stanislav Emelianov, Fabrice Manns, Kirill Larin

Proceedings Volume 8934, 89340Y (2014) https://doi.org/10.1117/12.2041976

KEYWORDS: Crystals, Optical coherence tomography, Natural surfaces, Biomedical optics, Tissues, Tissue optics, Acoustics, Elastography, Ultrasonography, Eye

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Proceedings Article | 4 March 2014 Paper

Mouse embryo manipulations with OCT guidance

Monica Garcia, Saba Syed, Andrew Coughlin, Shang Wang, Jennifer West, Kirill Larin, Irina Larina

Proceedings Volume 8953, 89530K (2014) https://doi.org/10.1117/12.2045989

KEYWORDS: Optical coherence tomography, Tissues, Visualization, Imaging systems, Gold, Optical imaging, Target designation, 3D image processing, Interferometry, Cardiovascular system

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Proceedings Article | 28 February 2014 Paper

Air-puff OCE for assessment of mouse cornea in vivo

Jiasong Li, Shang Wang, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill Larin

Proceedings Volume 8930, 893004 (2014) https://doi.org/10.1117/12.2042258

KEYWORDS: Cornea, In vivo imaging, Tissues, Tissue optics, Elastography, Coherence (optics), Imaging systems, Biomedical optics, Soft tissue optics, Optical coherence tomography

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Proceedings Article | 26 February 2014 Paper

Model-based optical coherence elastography using acoustic radiation force

Salavat Aglyamov, Shang Wang, Andrei Karpiouk, Jiasong Li, Stanislav Emelianov, Kirill Larin

Proceedings Volume 8946, 89460T (2014) https://doi.org/10.1117/12.2038584

KEYWORDS: Tissues, Acoustics, Elastography, Optical coherence tomography, Ultrasonography, Natural surfaces, Model-based design, Tissue optics, Transducers, Wave propagation

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Proceedings Article | 26 February 2014 Paper

Assessment of lamb wave dispersion in cornea using shear wave imaging optical coherence tomography (SWI-OCT)

Shang Wang, Kirill Larin

Proceedings Volume 8946, 894608 (2014) https://doi.org/10.1117/12.2040368

KEYWORDS: Cornea, Wave propagation, Dispersion, Coherence imaging, Optical coherence tomography, Phase velocity, Tissue optics, Optical imaging, Wave plates, Ultrasonography

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Proceedings Article | 26 February 2014 Paper

Improvement of tissue analysis and classification using optical coherence tomography combined with Raman spectroscopy

Chih-Hao Liu, Ji Qi, Jing Lu, Shang Wang, Chen Wu, Wei-Chuan Shih, Kirill Larin

Proceedings Volume 8942, 894208 (2014) https://doi.org/10.1117/12.2038508

KEYWORDS: Optical coherence tomography, Raman spectroscopy, Liver, Kidney, Remote sensing, Tissues, Tissue optics, Tumors, Intestine, Biological research

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SPIE Journal Paper | 2 October 2013 Open Access

Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo

Jiasong Li, Shang Wang, Ravi Manapuram, Manmohan Singh, Floredes Menodiado, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill Larin

JBO, Vol. 18, Issue 12, 121503, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.121503

KEYWORDS: Cornea, In vivo imaging, Tissues, Optical coherence tomography, Wave propagation, Eye models, Tissue optics, Silicon, Optical testing, Eye

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SPIE Journal Paper | 27 June 2013 Open Access

Three-dimensional computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas

Shang Wang, Chih-Hao Liu, Valery Zakharov, Alexander Lazar, Raphael Pollock, Kirill Larin

JBO, Vol. 19, Issue 02, 021102, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.021102

KEYWORDS: Tissues, Optical coherence tomography, Tissue optics, Tumors, 3D image processing, Signal attenuation, Spatial frequencies, Refractive index, Biological research, Soft tissue optics

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Proceedings Article | 26 March 2013 Paper

OCT guided microinjections for mouse embryonic research

Kirill Larin, Saba Syed, Andrew Coughlin, Shang Wang, Jennifer West, Mary Dickinson, Irina Larina

Proceedings Volume 8593, 85930E (2013) https://doi.org/10.1117/12.2006213

KEYWORDS: Optical coherence tomography, Gold, Signaling molecules, Transplantation, Animal model studies, Medical research, Mouse models, Visualization, Biomedical optics, Optical fiber cables

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Proceedings Article | 20 March 2013 Paper

Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement

Shang Wang, Jiasong Li, Srilatha Vantipalli, Ravi Kiran Manapuram, Davis Ingram, Michael Twa, Alexander Lazar, Dina Lev, Raphael Pollock, Kirill Larin

Proceedings Volume 8571, 85712B (2013) https://doi.org/10.1117/12.2007156

KEYWORDS: Tissues, Natural surfaces, Optical coherence tomography, Tumors, Transducers, Soft tissue optics, Tissue optics, Elastography, Biomedical optics, Wave propagation

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Proceedings Article | 20 March 2013 Paper

Dynamic OCE measurement of the biomechanical properties of gelatin phantom and mouse cornea in vivo

Jiasong Li, Shang Wang, Ravi Kiran Manapuram, Floredes Menodiado, Manmohan Singh, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill Larin

Proceedings Volume 8571, 85711T (2013) https://doi.org/10.1117/12.2007033

KEYWORDS: Cornea, In vivo imaging, Tissues, Eye models, Wave propagation, Silicon, Eye, Tissue optics, Velocity measurements, Optical coherence tomography

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Proceedings Article | 1 March 2013 Paper

Computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas

Shang Wang, Narendran Sudheendran, Chih-Hao Liu, Ravi Manapuram, Valery Zakharov, Davis Ingram, Alexander Lazar, Dina Lev, Raphael Pollock, Kirill Larin

Proceedings Volume 8580, 85800T (2013) https://doi.org/10.1117/12.2006638

KEYWORDS: Tissues, Optical coherence tomography, Tissue optics, Signal attenuation, Soft tissue optics, Imaging systems, Tumors, Image analysis, 3D image processing, Natural surfaces

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Showing 5 of 56 publications

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