Prof. Adrien E. Desjardins Profile

Prof. Adrien E. Desjardins

Associate Professor at Univ College London

SPIE Involvement:

Author

Publications (57)

Proceedings Article | 20 September 2023 Paper

Single optical fibre ultrasound transducer for rotational imaging

Richard Colchester, Edward Zhang, Paul Beard, Adrien Desjardins

Proceedings Volume 12608, 1260802 (2023) https://doi.org/10.1117/12.3005582

KEYWORDS: Ultrasonography, Optical fibers, Copper, Imaging devices, Ultrasound transducers, Signal to noise ratio, Pulsed laser operation, Image processing, Visualization, Stereoscopy

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Proceedings Article | 11 August 2023 Paper

Miniaturised all-optical ultrasound probe for thrombus imaging

Shaoyan Zhang, Chung Lim, Edward Zhang, Paul Beard, Adrien Desjardins, Richard Colchester

Proceedings Volume 12631, 1263110 (2023) https://doi.org/10.1117/12.2669613

KEYWORDS: Ultrasonography, Miniaturization, Optical fibers, Microresonators, Fiber coatings, Polydimethylsiloxane, Imaging systems, Imaging devices

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Proceedings Article | 27 March 2023 Poster

Visualisation of medical needles using photoacoustic imaging with candle soot composites coatings and deep learning

Mengjie Shi, Semyon Bodian, Simeon West, Sanjayan Sathasivam, Ross Gordon, Paul Collier, Tom Vercauteren, Adrien Desjardins, Sacha Noimark, Wenfeng Xia

Proceedings Volume PC12379, PC123792M (2023) https://doi.org/10.1117/12.2648775

KEYWORDS: Visualization, Composites, Photoacoustic imaging, Visibility, Light emitting diodes, Optical fibers, In vivo imaging, Ultrasonography, Tissues, Tissue optics

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Proceedings Article | 6 March 2023 Presentation

Real-time ultrasonic needle tip tracking with an integrated fibre-optic hydrophone

Christian Baker, Miguel Xochicale, Francois Joubert, Fang-yu Lin, Sunish Mathews, Dzhoshkun Shakir, Sebastien Ourselin, Anna David, Brian Dromey, Adrien Desjardins, Tom Vercauteren, Wenfeng Xia

Proceedings Volume PC12368, PC1236801 (2023) https://doi.org/10.1117/12.2650092

KEYWORDS: Ultrasonics, Visibility, Ultrasonography, Standards development, Sensors, Reticles, Medical device development, Imaging systems, Acoustics

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Proceedings Article | 6 March 2023 Presentation

Real-time 3D-photoacoustic tracking system for localisation of an intraoperative needle tip

Christian Baker, Weidong Liang, Mengjie Shi, Tianrui Zhao, Francois Joubert, Sebastien Ourselin, Tom Vercauteren, Richard Colchester, Simeon West, Adrien Desjardins, Wenfeng Xia

Proceedings Volume PC12368, PC1236805 (2023) https://doi.org/10.1117/12.2650170

KEYWORDS: Photoacoustic spectroscopy, 3D acquisition, Ultrasonography, Transmitters, Receivers, Imaging systems, Visualization, Visibility, Semiconductor lasers, Oxides

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Proceedings Article | 6 October 2021 Presentation + Paper

Real-time all-optical ultrasound imaging of a dynamic heart valve phantom

Richard Colchester, John Moore, Terry Peters, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 11879, 1187908 (2021) https://doi.org/10.1117/12.2598781

KEYWORDS: Ultrasonography, Heart, Transmitters, Optical fibers, Fiber optics, Visualization, Surgery, Receivers

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SPIE Journal Paper | 23 December 2020 Open Access

Multispectral tissue mapping: developing a concept for the optical evaluation of liver disease

Crispin Schneider, Daniil Nikitichev, Wenfeng Xia, Kurinchi Gurusamy, Adrien Desjardins, Brian Davidson

JMI, Vol. 7, Issue 06, 066001, (December 2020) https://doi.org/10.1117/12.10.1117/1.JMI.7.6.066001

KEYWORDS: Tissues, Absorption, Liver, Tissue optics, Cancer, Statistical analysis, Multispectral imaging, Cameras, Visualization, Liver cancer

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Purpose: Alterations in the optical absorption behavior of liver tissue secondary to pathological processes can be evaluated by multispectral analysis, which is increasingly being explored as an imaging adjunct for use in liver surgery. Current methods are either invasive or have a limited wavelength spectrum, which restricts utility. This proof of concept study describes the development of a multispectral imaging (MSI) method called multispectral tissue mapping (MTM) that addresses these issues. Approach: The imaging system consists of a tunable excitation light source and a near-infrared camera. Following the development stage, proof of concept experiments are carried out where absorption spectra from colorectal cancer liver metastasis (CRLM), hepatocellular carcinoma (HCC), and liver steatosis specimen are acquired and compared to controls. Absorption spectra are compared to histopathology examination as the current gold standard for tissue assessment. Generalized linear mixed modeling is employed to compare absorption characteristics of individual pixels and to select wavelengths for false color image processing with the aim of visually enhancing cancer tissue. Results: Analysis of individual pixels revealed distinct absorption spectra therefore suggesting that MTM is possible. A prominent absorption peak at 1210 nm was found in lipid-rich animal tissues and steatotic liver specimen. Liver cancer tissue had a heterogeneous appearance on MSI. Subsequent statistical analysis suggests that measuring changes in absorption behavior may be a feasible method to estimate the pixel-based probability of cancer being present. In CRLM, this was observed throughout 1100 to 1700 nm, whereas in HCC it was concentrated around 1140 and 1430 nm. False color image processing visibly enhances contrast between cancer and normal liver tissues. Conclusions: The system’s ability to enable no-touch MSI at 1100 to 1700 nm was demonstrated. Preliminary data suggest that MTM warrants further exploration as a potential imaging tool for the detection of liver cancer during surgery.

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Proceedings Article | 20 April 2020 Presentation

High resolution 3D photoacoustic scanner for clinical vascular imaging applications (Conference Presentation)

Nam Trung Huynh, Olivia Francies, Katerina Soteriou, Thomas Allen, Khoa Pham, Sacha Noimark, Semyon bodian, Adrien Desjardins, Jiaqi Zhu, Oshaani Abeyakoon, Filip Kuklis, Edward Zhang, Ben Cox, Andrew Plumb, Paul Beard

Proceedings Volume 11240, 1124003 (2020) https://doi.org/10.1117/12.2549559

KEYWORDS: 3D scanning, Photoacoustic spectroscopy, Laser scanners

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Proceedings Article | 20 February 2020 Presentation + Paper

Ex vivo assessment of the optical characteristics of human brain and tumour tissue

Jonathan Shapey, Yijing Xie, Elham Nabavi, Michael Ebner, Efthymios Maneas, Shakeel Saeed, Neil Dorward, Neil Kitchen, Adrien Desjardins, Sebastien Ourselin, Zane Jaunmuktane, Sebastian Brandner, Robert Bradford, Tom Vercauteren

Proceedings Volume 11251, 112510J (2020) https://doi.org/10.1117/12.2545694

KEYWORDS: Tissues, Tissue optics, Brain, Absorption, Scattering, Optical properties, Integrating spheres

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Proceedings Article | 22 July 2019 Paper

Optical interferometric temperature sensors for intravascular blood flow measurements

Elizabeth Carr, Eleanor Mackle, Malcolm Finlay, Charles Mosse, Joanna Coote, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 11075, 1107502 (2019) https://doi.org/10.1117/12.2527056

KEYWORDS: Domes, Temperature sensors, Sensors, Interferometry, Diffusers, Fiber optics, Blood, Optical fibers

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Proceedings Article | 19 July 2019 Paper

Large area all-optical ultrasound imaging using robotic control

Richard Colchester, Erwin Alles, George Dwyer, Efthymios Maneas, Danail Stoyanov, Adrien Desjardins

Proceedings Volume 11077, 110771G (2019) https://doi.org/10.1117/12.2525379

KEYWORDS: Ultrasonography, Robotics, Endoscopes, Optical fibers, Fiber optics, Integrated optics, Polymers, Multimode fibers

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Proceedings Article | 7 March 2019 Presentation

A hybrid approach of two-photon polymerization scaffold printing and microinjection of optically heterogenous material for the fabrication of vascular imaging phantoms (Conference Presentation)

Callum Little, Radhika Poduval, Richard Caulfield, Sacha Noimark, Richard Colchester, Chris Loder, Manish Tiwari, Roby Rakhit, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 10855, 1085507 (2019) https://doi.org/10.1117/12.2508642

KEYWORDS: Tissue optics, Two photon polymerization, 3D modeling, Printing, Vascular imaging, Tissues, Optical coherence tomography, 3D printing, Imaging systems, Device simulation

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Proceedings Article | 7 March 2019 Paper

Soft optically tuneable fluorescence phantoms based on gel wax and quantum dots: a tissue surrogate for fluorescence imaging validation

Yijing Xie, Efthymios Maneas, Shahraz Islam, William Peveler, Jonathan Shapey, Wenfeng Xia, Sebastien Ourselin, Ivan Parkin, Adrien Desjardins, Tom Vercauteren

Proceedings Volume 10862, 108621F (2019) https://doi.org/10.1117/12.2508348

KEYWORDS: Optical phantoms, Fluorescence spectroscopy, Quantum dots, Absorption, Scattering, Imaging systems, Brain

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Proceedings Article | 7 March 2019 Presentation

Ultrasonic needle tracking with a high-finesse Fabry-Perot fiber optic hydrophone (Conference Presentation)

Sunish Mathews, Sandy Mosse, Wenfeng Xia, Dzhoshkun Shakir, Yada Kunpalin, Edward Zhang, Paul Beard, Simeon West, Anna David, Adrien Desjardins

Proceedings Volume 10868, 108681D (2019) https://doi.org/10.1117/12.2509670

KEYWORDS: Ultrasonics, Fiber optics, Fabry–Perot interferometers, Ultrasonography, Sensors, Tissues, Tumors, Biopsy, Nerve, Target designation

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Proceedings Article | 4 March 2019 Presentation

Simultaneous photoacoustic imaging and white light video endoscopy for guiding laparoscopic surgery (Conference Presentation)

Rehman Ansari, Nam Huynh, Edward Zhang, Adrien Desjardins, Paul Beard

Proceedings Volume 10878, 108780Z (2019) https://doi.org/10.1117/12.2507548

KEYWORDS: Photoacoustic spectroscopy, Endoscopy, Sensors, Microelectromechanical systems, Mirrors, Endoscopes, Tissues, Visible radiation, Video, Ultrasonography

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White light endoscopy is widely used both as a diagnostic tool for the assessment of abdominal cancers and to help guide their surgical excision using minimally invasive procedures. However, the information it provides is limited to visual inspection of the tissue surface. Endoscopic ultrasonography provides depth-resolved morphological images but exhibits poor label-free microvascular contrast thus limiting its ability to identify and delineate deep seated tumours. These drawbacks can potentially be addressed by using a laparoscopic probe that provides co-registered photoacoustic (PA) and white light endoscopy images. With the help of PA contrast, the probe can visualise depth-resolved microvasculature and thus offers the prospect of more sensitive detection of tumours based on abnormal vascular anatomy and function. However, it is challenging to implement such a probe using conventional piezoelectric transducers. Their opaque nature makes it difficult to achieve forward-viewing capability in a small footprint as required for laparoscopic use as well as incorporate videoscopy. Furthermore, achieving sufficiently widebandwidth (tens of MHz) and λ/2 spatial sampling as required for high resolution endoscopic PA imaging present further challenges. To address these challenges, we present a rigid miniature forward-viewing endoscope that is based on a transparent optical ultrasound sensor which offers a wideband response up to 50 MHz with sub-100 µm spatial sampling. The probe is designed for laparoscopic use. It is 260 mm long and 9 mm in outer diameter to permit insertion via a standard 12 mm abdominal trochar and comprises a lens relay system with a high-finesse FP ultrasound sensor at its distal end. The sensor is designed to operate in the 1500 – 1600 nm spectral range with high transmission in the visible to near-infrared region (550 – 1200 nm). The latter not only enables delivery of near-infrared pulsed excitation light through the sensor to acquire PA images but also transmission of visible CW light for simultaneous acquisition of wide-field video images at the probe tip. A MEMS scanning mirror located at the proximal end of the probe scans the FP sensor via the optical relay with 8 focused beams from a CW tunable laser source (1550 nm centre wavelength) to map the generated photoacoustic waves. High-resolution 3D tomographic images are reconstructed using a time reversal algorithm and fused with the white light video images. The probe has 8 mm lateral field-of-view and the NEP is 200 Pa over 20 MHz bandwidth. The lateral spatial resolution is 52 µm at a depth of 1 mm decreasing to 110µm at a depth of 7 mm. The axial resolution is 29 µm over this depth range. To demonstrate potential clinical applicability, the probe was evaluated in an in vivo sheep study and shown to provide excellent high resolution 3D images of vascular structures in the liver, kidney and placentomes. This novel forward-viewing PAE probe could provide new opportunities for the photoacoustic assessment of tumours in the liver, cancer in the GI tract and guiding minimally invasive procedures in abdominal surgery and foetal medicine.

Proceedings Article | 4 March 2019 Presentation

Dual mode photoacoustic and ultrasound imaging system based on a Fabry-Perot scanner (Conference Presentation)

Khoa Pham, Sacha Noimark, Nam Trung Huynh, Edward Zhang, Adrien Desjardins, Ben Cox, Paul Beard

Proceedings Volume 10878, 1087826 (2019) https://doi.org/10.1117/12.2506922

KEYWORDS: Scanners, Imaging systems, Photoacoustic spectroscopy, Ultrasonography, Fabry–Perot interferometers, 3D image processing, Tissues, Laser scanners, 3D scanning, In vivo imaging

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Compared to piezoelectric based photoacoustic (PA) scanners, the planar Fabry-Perot (FP) scanner has several advantages. It can provide small element size with high sensitivity, a smooth broadband frequency response, and is transparent to excitation light. This enables the FP scanner to provide excellent high-resolution in vivo PA images of soft tissue to depths up to approximately 10 mm. However, unlike piezoelectric scanners, the FP scanner in its current form cannot provide a pulse-echo ultrasound (US) as well as a PA image, which is useful because of the additional tissue contrast it provides. To address this, a dual mode FP scanner-based system that, for the first time, can acquire co-registered 3D PA and US images has been developed. In order to provide an optical US generation capability, the FP ultrasound sensor was coated with a novel Gold-Nanoparticle-PDMS composite which was excited with nanosecond laser pulses to generate plane wave US pulses. By modifying the FP sensor in this way, it now acts as an US transmitter as well as a receiver. The coating is highly absorbing at the US generation wavelength (>95%) but transparent at the PA excitation wavelength, the latter to allow the system to also operate in PA imaging mode as before. The generated US pulses exhibited peak pressures in the MPa range, which is comparable to the output of conventional piezoelectric based medical US scanners. The pulses had a broad bandwidth (>40 MHz) and the emitted wavefront was planar to within λ/10 at 10 MHz. PA and pulse-echo US signals were mapped in turn by the FP scanner over centimetre scale areas with a step size of 100 μm and an element size of 64 μm. The -3dB bandwidth of the FP sensor was 30 MHz. Reconstruction methods using a k-space formulation recovered co-registered 3D PA and US images. The system’s lateral spatial resolution was evaluated by imaging a line target at depths up to 10 mm and ranged between 50 and 120 μm for both modes. Arbitrarily shaped 3D objects were imaged to demonstrate the volumetric US imaging capability of the scanner. Tissue mimicking phantoms, with impedance mismatches representative of soft tissues, and ex vivo tissue samples were imaged with the system as well as a conventional clinical US scanner for comparison. Finally, the system obtained promising high-resolution 3D dual mode PA-US images for a variety of phantoms with contrast based on both optical absorption and acoustic impedance. This novel all-optical system has the potential to add complementary morphological contrast to photoacoustic vascular images which could aid the clinical assessment of superficial tumours, lymph node disease and other conditions.

Proceedings Article | 4 March 2019 Presentation

Real-time 2D all-optical ultrasound imaging with a dynamically reconfigurable imaging aperture (Conference Presentation)

Erwin Alles, Adrien Desjardins

Proceedings Volume 10878, 108780I (2019) https://doi.org/10.1117/12.2507792

KEYWORDS: Ultrasonography, Real time imaging, Tissue optics, Transducers, Image quality, Tissues, Nanocomposites, Mirrors, Light, Acoustics

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Proceedings Article | 4 March 2019 Presentation

Radio-frequency ablation monitoring through real-time, video-rate all-optical ultrasound imaging (Conference Presentation)

Erwin Alles, Richard Colchester, Sacha Noimark, Edward Zhang, Paul Beard, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 10855, 108550M (2019) https://doi.org/10.1117/12.2507795

KEYWORDS: Ultrasonography, Imaging systems, Radiofrequency ablation, Image resolution, Cardiology, Atrial fibrillation, Tissues, Magnetic resonance imaging, Electronic imaging, Transducers

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Proceedings Article | 4 March 2019 Presentation

International Photoacoustic Standardisation Consortium (IPASC): overview (Conference Presentation)

Sarah Bohndiek, Joanna Brunker, Janek Gröhl, Lina Hacker, James Joseph, William Vogt, Paolo Armanetti, Hisham Assi, Jeffrey Bamber, Paul Beard, Thomas Berer, Richard Bouchard, Kimberly Briggman, Lucia Cavigli, Bryan Clingman, Ben Cox, Adrien Desjardins, Andrew Heinmiller, Jeesong Hwang, Eno Hysi, Aoife Ivory, Jithin Jose, Thomas Kirchner, Jan Klohs, Lena Maier-Hein, Efthymios Maneas, Julia Mannheim, Srirang Manohar, Lacey McNally, Luca Menichetti, Steven Miller, Stefan Morscher, Ruiqing Ni, Yoko Okamura, Malini Olivo, Marty Pagel, Geoff Parker, Anna Pelagotti, Antonio Pifferi, Srinath Rajagopal, Fulvio Ratto, Daniel Razansky, Lisa Richards, Avihai Ron, Mithun Kuniyil Ajith Singh, Maximillian Waldner, Kun Wang, Lihong Wang, Wenfeng Xia, Bajram Zeqiri

Proceedings Volume 10878, 108781N (2019) https://doi.org/10.1117/12.2506044

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Proceedings Article | 27 February 2019 Paper

Enhancing photoacoustic visualization of medical devices with elastomeric nanocomposite coatings

Wenfeng Xia, Sacha Noimark, Efthymios Maneas, Nina Montana Brown, Mithun Kuniyil Ajith Singh, Sebastien Ourselin, Simeon West, Adrien Desjardins

Proceedings Volume 10878, 108783G (2019) https://doi.org/10.1117/12.2508658

KEYWORDS: Photoacoustic imaging, Medical devices, Imaging systems, Visualization, Composites, Ultrasonography, Visibility, Photoacoustic spectroscopy, Tissues, Nanocomposites, Light emitting diodes

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Proceedings Article | 27 February 2019 Presentation + Paper

Imaging of human peripheral blood vessels during cuff occlusion with a compact LED-based photoacoustic and ultrasound system

Wenfeng Xia, Efthymios Maneas, Nam Trung Huynh, Mithun Kuniyil Ajith Singh, Nina Montana Brown, Sebastien Ourselin, Edward Gilbert-Kawai, Simeon West, Adrien Desjardins

Proceedings Volume 10878, 1087804 (2019) https://doi.org/10.1117/12.2509666

KEYWORDS: Photoacoustic imaging, Arteries, Imaging systems, Photoacoustic spectroscopy, Ultrasonography, Digital imaging, Blood vessels, Blood circulation, Visualization, Light emitting diodes, Image restoration

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Proceedings Article | 27 February 2019 Paper

3D printed kidney phantoms for an LED-based photoacoustic and ultrasound imaging system

D. Nikitichev, K. Murawski, G. Harris, G. Perkins, S. Mosse, E. Maneas, W. Xia, V. Arumuham, Mithun Kunyuil Ajith Singh, S. Choong, A. Desjardins, J. Hebden

Proceedings Volume 10878, 1087868 (2019) https://doi.org/10.1117/12.2509831

KEYWORDS: Kidney, Photoacoustic spectroscopy, Tissue optics, 3D printing, Ultrasonography, 3D modeling, Acoustics, Printing, Photoacoustic imaging, Tissues

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Proceedings Article | 27 February 2019 Presentation + Paper

Wall-less vascular poly(vinyl) alcohol gel ultrasound imaging phantoms using 3D printed vessels

Eleanor Mackle, Efthymios Maneas, Callum Little, Elizabeth Carr, Wenfeng Xia, Daniil Nikitichev, Roby Rakhit, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 10870, 108700P (2019) https://doi.org/10.1117/12.2510033

KEYWORDS: Ultrasonography, 3D printing, Tissues, Printing, 3D image processing, Imaging systems, Ultrasonics, Fabrication

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SPIE Journal Paper | 15 February 2019 Open Access

Micron resolution, high-fidelity three-dimensional vascular optical imaging phantoms

Callum D. Little, Radhika K. Poduval, Richard Caulfield, Sacha Noimark, Richard J. Colchester, Chris D. Loder, Manish K. Tiwari, Roby D. Rakhit, Ioannis Papakonstantinou, Adrien E. Desjardins

JBO, Vol. 24, Issue 02, 020502, (February 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.020502

KEYWORDS: Tissue optics, Two photon polymerization, 3D modeling, Printing, 3D image processing, Silicon, Tissues, Scattering, Image resolution, Optical imaging

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Proceedings Article | 5 September 2018 Presentation + Paper

3D printed micro-scale fiber optic probe for intravascular pressure sensing

Radhika Poduval, Jo Coote, Charles Mosse, Malcolm Finlay, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 10728, 107280B (2018) https://doi.org/10.1117/12.2321980

KEYWORDS: Sensors, Fiber optics sensors, Fiber optics, Optical components, Temperature metrology, Computer aided design, Printing, Optical fibers, Interferometry, Two photon polymerization, Blood pressure

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Proceedings Article | 15 March 2018 Presentation

Forward viewing 3D photoacoustic endoscopic probe for guiding interventional procedures (Conference Presentation)

Rehman Ansari, Edward Zhang, Adrien Desjardins, Paul Beard

Proceedings Volume 10494, 1049414 (2018) https://doi.org/10.1117/12.2287139

KEYWORDS: Photoacoustic spectroscopy, Endoscopy, Sensors, Ultrasonography, Tissues, Photoacoustic tomography, Biopsy, Image resolution, Spatial resolution, Surgery

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Endoscopic ultrasonography (EUS) is an important clinical tool for the assessment of tumours in the abdominal cavity and guiding minimally invasive surgical procedures. However, one of the drawbacks of EUS is the lack of soft tissue contrast which can compromise its ability to visualise the microvasculature and thus delineate tu mour margins. Photoacoustic endoscopy (PAE) could potentially overcome this drawback as it can visualise the microvasculature with high contrast due to the strong optical absorption of haemoglobin. Previously, we have demonstrated an all-optical laboratory demonstrator PAE probe using standard bulk optical components. We now present a miniaturized flexible PAE probe with a 6 mm outer diameter and improved acoustic sensitivity capable of high resolution volumetric imaging in the forward-viewing configuration. The probe comprises a 1.5 mm diameter flexible coherent fibre bundle consisting of 18,000 fibre-optic cores with a transparent 80MHz Fabry-Pérot ultrasound sensor at its distal end. The FP sensor thus acts as a high density 2D array composed of 18,000 individually addressable ultrasound detectors, each with a bandwidth of 80MHz and an element size and centre-to-centre spacing of 40 µm and 44 µm, respectively. The pulsed excitation light is coupled through all of the fibre-optic cores from the proximal end, and the generated photoacoustic waves are detected in backward mode by sequentially interrogating the FP sensor through individual fibre optic cores. This configuration allows for very fine sampling of the photoacoustic waves and thus high lateral spatial resolution and image fidelity. This new approach to photoacoustic endoscopy offers significant advantages over previous piezoelectric based distal-end scanning probes. These include a forward viewing capability and a wider detection bandwidth and finer spatial sampling than achievable with piezoelectric receivers, a high degree of miniaturisation, no moving parts at the distal end and relatively simple and inexpensive fabrication. We have characterized the PAE probe in terms of its field of view, noise-equivalent pressure (NEP), and lateral and axial PSF. The lateral field of view is 5 mm and the NEP is 500 Pa over 20MHz bandwidth. The lateral spatial resolution is 50 µm at a depth of 1 mm decreasing to 150µm at a depth of 3 mm. The axial resolution is 33 µm over this depth range. The probe have also been evaluated using a variety of tissue phantoms and ex vivo tissues and shown to provide excellent high resolution 3D images of the vasculature. It is anticipated that this novel forward-viewing probe will provide new opportunities for the photoacoustic assessment of tumours in the liver and other abdominal organs, cancer in the GI tract and guiding minimally invasive procedures in abdominal surgery and foetal medicine.

Proceedings Article | 15 March 2018 Presentation

Patient-specific tissue-mimicking phantoms for photoacoustic and ultrasound imaging (Conference Presentation)

Efthymios Maneas, Wenfeng Xia, Daniil Nikitichev, Rosalind Pratt, Sebastien Ourselin, Simeon West, Anna David, Malcolm Finlay, Tom Vercauteren, Adrien Desjardins

Proceedings Volume 10494, 1049425 (2018) https://doi.org/10.1117/12.2288998

KEYWORDS: Ultrasonography, Tissue optics, Photoacoustic spectroscopy, Minerals, Soft tissue optics, Acoustics, 3D printing, Photoacoustic imaging, Imaging systems, Tissues

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Proceedings Article | 15 March 2018 Presentation

All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography (Conference Presentation)

Sunish Mathews, Callum Little, Chris Loder, Roby Rakhit, Wenfeng Xia, Edward Zhang, Paul Beard, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 10494, 1049416 (2018) https://doi.org/10.1117/12.2289631

KEYWORDS: Optical coherence tomography, Photoacoustic imaging, Intravascular ultrasound, Coherence imaging, Photoacoustic spectroscopy, Visualization, Sensors, Image resolution, Optical imaging, Fabry–Perot interferometers

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Proceedings Article | 14 March 2018 Presentation

Fibre-optic pressure and temperature measurements using phase-resolved low-coherence interferometry (Conference Presentation)

Joanna Coote, Sandy Mosse, Sacha Noimark, Erwin Alles, Callum Little, Chris Loder, Roby Rakhit, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 10488, 104880E (2018) https://doi.org/10.1117/12.2290007

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Proceedings Article | 14 March 2018 Presentation

All-optical side-viewing intravascular ultrasound imaging probe (Conference Presentation)

Richard Colchester, Sacha Noimark, Edward Zhang, Malcolm Finlay, Callum Little, Chris Loder, Roby Rahkit, Ivan Parkin, Paul Beard, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 10471, 104710V (2018) https://doi.org/10.1117/12.2289848

KEYWORDS: Ultrasonography, Intravascular ultrasound, Transducers, Photoacoustic spectroscopy, Optical fibers, Carbon nanotubes, Laser beam diagnostics, Image resolution, Transmitters, Composites

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Proceedings Article | 19 February 2018 Presentation + Paper

Human placental vasculature imaging using an LED-based photoacoustic/ultrasound imaging system

Efthymios Maneas, Wenfeng Xia, Mithun Kuniyil Ajith Singh, Naoto Sato, Toshitaka Agano, Sebastien Ourselin, Simeon West, Anna David, Tom Vercauteren, Adrien Desjardins

Proceedings Volume 10494, 104940Y (2018) https://doi.org/10.1117/12.2288995

KEYWORDS: Imaging systems, Ultrasonography, Light emitting diodes, Fetus, Medical research, Photoacoustic spectroscopy, Visualization, Photography, Laser coagulation, Photoacoustic imaging

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SPIE Journal Paper | 14 November 2017 Open Access

Wide-field spectrally resolved quantitative fluorescence imaging system: toward neurosurgical guidance in glioma resection

Yijing Xie, Maria Thom, Michael Ebner, Victoria Wykes, Adrien Desjardins, Anna Miserocchi, Sebastien Ourselin, Andrew McEvoy, Tom Vercauteren

JBO, Vol. 22, Issue 11, 116006, (November 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.11.116006

KEYWORDS: Luminescence, Tumors, Imaging systems, Diffuse reflectance spectroscopy, Tissues, Tissue optics, Cameras, RGB color model, Absorption, Surgery

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Proceedings Article | 1 August 2017 Paper

Optical fiber laser ultrasound transmitter with electrospun composite for minimally invasive medical imaging

Radhika Poduval, Sacha Noimark, Richard Colchester, Tom Macdonald, Ivan Parkin, Adrien Desjardins, Ioannis Papakonstantinou

Proceedings Volume 10415, 104150B (2017) https://doi.org/10.1117/12.2286162

KEYWORDS: Fiber optics sensors, Ultrasonography, Medical imaging, Optical fibers, Laser optics, Transmitters, Composites, Carbon nanotubes, Polymers

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Proceedings Article | 24 April 2017 Presentation

Three-dimensional printed ultrasound and photoacoustic training phantoms for vasculature access (Conference Presentation)

Daniil Nikitichev, Wenfeng Xia, Simeon West, Adrien Desjardins, Sebastien Ourselin, Tom Vercauteren

Proceedings Volume 10064, 100640V (2017) https://doi.org/10.1117/12.2253135

KEYWORDS: 3D printing, Ultrasonography, Photoacoustic spectroscopy, Photoacoustic imaging, 3D modeling, Tissues, Medical imaging, Visualization, Printing, Minerals

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Proceedings Article | 19 April 2017 Presentation

Development and characterisation of a brain tumour mimicking protoporphyrin IX fluorescence phantom (Conference Presentation)

Yijing Xie, Cristiana Tisca, William Peveler, Sacha Noimark, Adrien Desjardins, Ivan Parkin, Sebastien Ourselin, Tom Vercauteren

Proceedings Volume 10049, 100490F (2017) https://doi.org/10.1117/12.2252018

KEYWORDS: Neuroimaging, Luminescence, Nanoparticles, Brain, Optical phantoms, Optical components, Optical testing, Tissue optics, Optical properties, Scattering

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Proceedings Article | 23 March 2017 Presentation + Paper

All-optical endoscopic probe for high resolution 3D photoacoustic tomography

R. Ansari, E. Zhang, A. Desjardins, P. Beard

Proceedings Volume 10064, 100641W (2017) https://doi.org/10.1117/12.2250617

KEYWORDS: Endoscopy, Sensors, Signal detection, Photoacoustic tomography, 3D image reconstruction, Ultrasonography, Spatial resolution, Imaging systems, Continuous wave operation, Wavelength tuning

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Proceedings Article | 27 February 2017 Open Access

Multi-scale spectrally resolved quantitative fluorescence imaging system: towards neurosurgical guidance in glioma resection

Yijing Xie, Maria Thom, Anna Miserocchi, Andrew McEvoy, Adrien Desjardins, Sebastien Ourselin, Tom Vercauteren

Proceedings Volume 10050, 1005002 (2017) https://doi.org/10.1117/12.2250159

KEYWORDS: Luminescence, Imaging systems, Tissues, Neuroimaging, Brain, Surgery, Fluorescence spectroscopy, Systems modeling, Tissue optics, Visualization, Light emitting diodes, Diffuse reflectance spectroscopy, Signal detection

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Proceedings Article | 27 April 2016 Presentation

Photoacoustic endoscopy probe using a coherent fibre-optic bundle and Fabry-Pérot ultrasound sensor (Conference Presentation)

Rehman Ansari, Paul Beard, Edward Zhang, Adrien Desjardins

Proceedings Volume 9708, 97080L (2016) https://doi.org/10.1117/12.2209687

KEYWORDS: Sensors, Photoacoustic spectroscopy, Endoscopy, Ultrasonography, Signal detection, Laser beam diagnostics, Reconstruction algorithms, 3D image reconstruction, 3D image processing, Tissues

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There is considerable interest in the development of photoacoustic endoscopy (PAE) probes for the clinical assessment of pathologies in the gastrointestinal (GI) tract, guiding minimally invasive laparoscopic surgeries and applications in foetal medicine. However, most previous PAE probes integrate mechanical scanners and piezoelectric transducers at the distal end which can be technically complex, expensive and pose challenges in achieving the necessary level of miniaturisation. We present two novel all-optical forward-viewing endoscopic probes operating in widefield tomography mode that have the potential to overcome these limitations. In one configuration, the probe comprises a transparent 40 MHz Fabry-Pérot ultrasound sensor deposited at the tip of a rigid, 3 mm diameter coherent fibre-optic bundle. In this way, the distal end of coherent fibre bundle acts as a 2D array of wideband ultrasound detectors. In another configuration, an optical relay is used between the distal end face of flexible fibre bundle and the Fabry-Pérot sensor to enlarge the lateral field of view to 6 mm x 6 mm. In both configurations, the pulsed excitation laser beam is full-field coupled into the fibre bundle at the proximal end for uniform backward-mode illumination of the tissue at the probe tip. In order to record the photoacoustic waves arriving at the probe tip, the proximal end of the fibre bundle is optically scanned in 2D with a CW wavelength-tunable interrogation laser beam thereby interrogating different spatial points on the sensor. A time-reversal image reconstruction algorithm was used to reconstruct a 3D image from the detected signals. The 3D field of view of the flexible PAE probe is 6 mm x 6 mm x 6 mm and the axial and lateral spatial resolution is 30 µm and 90 µm, respectively. 3D imaging capability is demonstrated using tissue phantoms, ex vivo tissues and in vivo. To the best of our knowledge, this is the first forward-viewing implementation of a photoacoustic endoscopy probe, and it offers several advantages over previous distal-end scanning probes. These include a high degree of miniaturisation, no moving parts at the distal end and simple and inexpensive fabrication with the potential to realise disposable probes for clinical imaging of the GI tract and other minimally invasive applications.

Proceedings Article | 27 April 2016 Presentation

All-optical pulse-echo ultrasound probe for intravascular imaging (Conference Presentation)

Richard Colchester, Sacha Noimark, Charles Mosse, Edward Zhang, Paul Beard, Ivan Parkin, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 9689, 96893I (2016) https://doi.org/10.1117/12.2213757

KEYWORDS: Ultrasonography, Tissues, Intravascular ultrasound, Image resolution, Photoacoustic spectroscopy, Echocardiography, Cardiology, Carbon, Composites, Fabry–Perot interferometers

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Proceedings Article | 18 March 2016 Presentation + Paper

Miniature fibre optic probe for minimally invasive photoacoustic sensing

Sunish Mathews, Edward Zhang, Adrien Desjardins, Paul Beard

Proceedings Volume 9708, 97082R (2016) https://doi.org/10.1117/12.2211661

KEYWORDS: Sensors, Fiber optics, Fabry–Perot interferometers, Optical fibers, GRIN lenses, Acoustics, Tissues, Fiber optics sensors, Signal detection, Blood vessels, Single mode fibers, Wavelength division multiplexing

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Proceedings Article | 15 March 2016 Presentation + Paper

Interventional multi-spectral photoacoustic imaging in laparoscopic surgery

Emma Hill, Wenfeng Xia, Daniil Nikitichev, Kurinchi Gurusamy, Paul Beard, David Hawkes, Brian Davidson, Adrien Desjardins

Proceedings Volume 9708, 97080B (2016) https://doi.org/10.1117/12.2208428

KEYWORDS: Laparoscopy, Surgery, Ultrasonography, Liver, Photoacoustic imaging, Photoacoustic spectroscopy, Monte Carlo methods, Image processing, Liver cancer, Visualization, Tissue optics, Imaging systems, Tissues, Transducers

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Proceedings Article | 15 March 2016 Paper

Interventional multispectral photoacoustic imaging with a clinical linear array ultrasound probe for guiding nerve blocks

Wenfeng Xia, Simeon West, Daniil Nikitichev, Sebastien Ourselin, Paul Beard, Adrien Desjardins

Proceedings Volume 9708, 97080C (2016) https://doi.org/10.1117/12.2209047

KEYWORDS: Ultrasonography, Nerve, Photoacoustic imaging, Tissues, Photoacoustic spectroscopy, Multispectral imaging, Blood vessels, Imaging arrays, Data modeling, Spectroscopes, Imaging systems, Tissue optics, In vivo imaging

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SPIE Journal Paper | 18 November 2015 Open Access

Interventional multispectral photoacoustic imaging with a clinical ultrasound probe for discriminating nerves and tendons: an ex vivo pilot study

Jean Martial Mari, Wenfeng Xia, Simeon West, Adrien Desjardins

JBO, Vol. 20, Issue 11, 110503, (November 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.11.110503

KEYWORDS: Nerve, Tissues, Multispectral imaging, Imaging systems, Photoacoustic imaging, Ultrasonography, Absorption, Tissue optics, Photoacoustic spectroscopy, Optical parametric oscillators

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SPIE Journal Paper | 17 August 2015 Open Access

Quantification of light attenuation in optically cleared mouse brains

Angela d’Esposito, Daniil Nikitichev, Adrien Desjardins, Simon Walker-Samuel, Mark Lythgoe

JBO, Vol. 20, Issue 08, 080503, (August 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.8.080503

KEYWORDS: Brain, Tissue optics, Signal attenuation, Optical clearing, Tissues, Absorption, Spectroscopy, Light scattering, Hydrogen, Refractive index

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SPIE Journal Paper | 11 August 2015 Open Access

Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures

Wenfeng Xia, Daniil Nikitichev, Jean Martial Mari, Simeon West, Rosalind Pratt, Anna David, Sébastien Ourselin, Paul Beard, Adrien Desjardins

JBO, Vol. 20, Issue 08, 086005, (August 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.8.086005

KEYWORDS: Imaging systems, Tissue optics, Multispectral imaging, Photoacoustic spectroscopy, Absorption, Blood, Ultrasonography, Photoacoustic imaging, Tissues, Optical fibers

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Proceedings Article | 16 July 2015 Paper

Photoacoustic endoscopy probe using a coherent fibre optic bundle

R. Ansari, E. Zhang, S. Mathews, A. Desjardins, P. Beard

Proceedings Volume 9539, 953905 (2015) https://doi.org/10.1117/12.2183820

KEYWORDS: Photoacoustic spectroscopy, Sensors, Endoscopy, Transducers, Acoustics, Ultrasonography, 3D image processing, Surgery, Image sensors, Reconstruction algorithms

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Proceedings Article | 16 July 2015 Paper

Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures

Wenfeng Xia, Charles Mosse, Richard Colchester, Jean Martial Mari, Daniil Nikitichev, Simeon West, Sebastien Ourselin, Paul Beard, Adrien Desjardins

Proceedings Volume 9539, 95390K (2015) https://doi.org/10.1117/12.2182647

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Tissues, Tissue optics, Ultrasonics, Receivers, Medical devices, Visualization, Coating, Natural surfaces

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Proceedings Article | 16 July 2015 Paper

An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures

Wenfeng Xia, Daniil Nikitichev, Jean Martial Mari, Simeon West, Sebastien Ourselin, Paul Beard, Adrien Desjardins

Proceedings Volume 9539, 95390D (2015) https://doi.org/10.1117/12.2183798

KEYWORDS: Ultrasonography, Imaging systems, Tissue optics, Tissues, Multispectral imaging, Photoacoustic imaging, Absorption, Photoacoustic spectroscopy, Receivers, Tumors

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Proceedings Article | 13 March 2015 Paper

Optical clearing of the mouse brain and light attenuation quantitation

Angela d'Esposito, Daniil Nikitichev, Adrien Desjardins, Simon Walker-Samuel, Mark Lythgoe

Proceedings Volume 9321, 93210R (2015) https://doi.org/10.1117/12.2075580

KEYWORDS: Brain, Signal attenuation, Tissues, Optical clearing, Tissue optics, Spectroscopy, Hydrogen, Optical testing, Light scattering, Cerebellum

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Proceedings Article | 11 March 2015 Paper

Real-time needle guidance with photoacoustic and laser-generated ultrasound probes

Richard Colchester, Charles Mosse, Daniil Nikitichev, Edward Zhang, Simeon West, Paul Beard, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 9323, 932321 (2015) https://doi.org/10.1117/12.2080772

KEYWORDS: Ultrasonography, Optical fibers, Photoacoustic spectroscopy, Coating, Tissue optics, Tissues, Sensors, Laser beam diagnostics, Blood vessels, Imaging systems

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Proceedings Article | 3 March 2014 Paper

Multispectral photoacoustic imaging of nerves with a clinical ultrasound system

Jean Martial Mari, Simeon West, Paul Beard, Adrien Desjardins

Proceedings Volume 8943, 89430W (2014) https://doi.org/10.1117/12.2036717

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Nerve, Absorption, Photoacoustic imaging, Tissues, Multispectral imaging, Imaging systems, Spectroscopy, Reflectivity

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Proceedings Article | 3 March 2014 Paper

Fiber optic ultrasound transducers with carbon/PDMS composite coatings

Charles Mosse, Richard Colchester, Davinder Bhachu, Edward Zhang, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 8943, 89430P (2014) https://doi.org/10.1117/12.2037283

KEYWORDS: Optical fibers, Ultrasonography, Optical coatings, Composites, Transducers, Tissue optics, Reflectivity, Natural surfaces, Heart, Carbon nanotubes

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Proceedings Article | 20 February 2014 Paper

Needle-tip localization using an optical fibre hydrophone

Jean Martial Mari, Simeon West, Paul Beard, Adrien Desjardins

Proceedings Volume 8938, 893804 (2014) https://doi.org/10.1117/12.2036703

KEYWORDS: Ultrasonography, Optical fibers, Sensors, Nerve, Signal detection, Ultrasonics, Medical devices, LabVIEW, Data acquisition, Transducers

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SPIE Journal Paper | 1 July 2011 Open Access

Needle stylet with integrated optical fibers for spectroscopic contrast during peripheral nerve blocks

Adrien Desjardins, Marjolein van der Voort, Stefan Roggeveen, Gerald Lucassen, Walter Bierhoff, Benno Hendriks, Marcus Brynolf, Bjorn Holmstrom

JBO, Vol. 16, Issue 07, 077004, (July 2011) https://doi.org/10.1117/12.10.1117/1.3598852

KEYWORDS: Nerve, Tissues, Optical fibers, Absorption, Tissue optics, Integrated optics, Spectroscopy, Natural surfaces, Optical spectroscopy, Veins

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SPIE Journal Paper | 1 February 2011 Open Access

High-resolution resonant and nonresonant fiber-scanning confocal microscope

Benno Hendriks, Walter Bierhoff, Jeroen Horikx, Adrien Desjardins, Cees Hezemans, Gert t'Hooft, Gerald Lucassen, Nenad Mihajlovic

JBO, Vol. 16, Issue 02, 026007, (February 2011) https://doi.org/10.1117/12.10.1117/1.3534781

KEYWORDS: Microscopes, Objectives, Scanners, Confocal microscopy, Tissues, Reflectivity, Actuators, Arteries, Electromagnetism, Tissue optics

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SPIE Journal Paper | 1 May 2010 Open Access

Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm

Rami Nachabe, Benno Hendriks, Adrien Desjardins, Marjolein van der Voort, Martin van der Mark, Henricus Sterenborg

JBO, Vol. 15, Issue 03, 037015, (May 2010) https://doi.org/10.1117/12.10.1117/1.3454392

KEYWORDS: Absorption, Tissues, Scattering, Optical fibers, Biological research, Scattering media, Water, Statistical analysis, Optical properties, Particles

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Proceedings Article | 24 February 2009 Paper

Extracting optical properties from diffuse optical spectroscopy

Rami Nachabé, Rik Harbers, Adrien Desjardins, Marjolein van der Voort, Guus A. Braun, Benno H. Hendriks

Proceedings Volume 7187, 71871C (2009) https://doi.org/10.1117/12.808244

KEYWORDS: Scattering, Absorption, Diffusion, Monte Carlo methods, Optical properties, Tissues, Reflectivity, Diffuse reflectance spectroscopy, Light scattering, Photon transport

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Showing 5 of 57 publications

Conference Committee Involvement (1)

Optical Coherence Tomography and Coherence Techniques VI

13 May 2013 | Munich, Germany

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