Prof. Xavier R. Intes Profile

Prof. Xavier R. Intes

Professor

SPIE Involvement:

Conference Chair | Author | Editor

Websites:

Personal Website

Publications (111)

Proceedings Article | 23 October 2024 Paper

A 3D-printed table for hybrid x-ray CT and optical imaging of a live mouse

Wenxuan Xue, Yuxuan Liang, Mengzhou Li, Shan Gao, Xavier Intes, Ge Wang

Proceedings Volume 13152, 131521L (2024) https://doi.org/10.1117/12.3029550

KEYWORDS: Imaging systems, Computed tomography, Optical imaging, Animals

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Proceedings Article | 13 March 2024 Presentation + Paper

Multiplexed fluorescence lifetime imaging of near-infrared fluorescent proteins in 3D tumor spheroids

Catherine Sherry, Luis Chavez, Ryan Kanai, Shan Gao, John Lamar, Xavier Intes, Margarida Barroso

Proceedings Volume 12862, 1286208 (2024) https://doi.org/10.1117/12.3003280

KEYWORDS: Near infrared, Fluorescence, Tumors, Fluorescence lifetime imaging, In vivo imaging, Multiplexing, 3D modeling, Fluorescence tomography, Fluorescence imaging, Fluorescent proteins

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Proceedings Article | 13 March 2024 Presentation

Near-infrared fluorescence lifetime FRET microscopy differentiates between drug-target binding versus non-specific accumulation in various 3D breast cancer models

Catherine Sherry, Cassandra Roberge, Christopher James, Arun Asif, Xavier Intes, David Corr, Margarida Barroso

Proceedings Volume PC12847, PC128470V (2024) https://doi.org/10.1117/12.3003205

KEYWORDS: 3D modeling, Fluorescence resonance energy transfer, Tumor growth modeling, Microscopy, Fluorescence, Breast cancer, Near infrared, Systems modeling, Fluorescence lifetime imaging, Data modeling

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Proceedings Article | 13 March 2024 Presentation

Using meditope-based antibody labeling to improve fluorescence lifetime FRET imaging

Amit Verma, Catherine Sherry, Nanxue Yuan, Vikas Pandey, John Williams, Xavier Intes, Margarida Barroso

Proceedings Volume PC12847, PC128470S (2024) https://doi.org/10.1117/12.3008753

KEYWORDS: Fluorescence resonance energy transfer, Antibodies, Fluorescence, Biological imaging, Tumors, Near infrared, Fluorescence imaging, In vivo imaging, Dyes, Target detection

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Proceedings Article | 13 March 2024 Presentation

Macroscopy fluorescence lifetime FRET monitors drug-target engagement in tumors in vivo

Amit Verma, Catherine Sherry, Vikas Pandey, Nanxue Yuan, John Williams, Xavier Intes, Margarida Barroso

Proceedings Volume PC12821, PC128210F (2024) https://doi.org/10.1117/12.3008749

KEYWORDS: Tumors, Fluorescence resonance energy transfer, In vivo imaging, Fluorescence, Near infrared, Animal model studies, Optical imaging, Collagen, Tissues, Resonance energy transfer

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Proceedings Article | 13 March 2024 Poster

Fluorescence lifetime tomography via deep learning

Navid Ibtehaj Nizam, Vikas Pandey, Jason Smith, Ismail Erbas, Xavier Intes

Proceedings Volume PC12834, PC128340H (2024) https://doi.org/10.1117/12.3000108

KEYWORDS: Fluorescence, Fluorescence tomography, Deep learning, Molecular biology, Fluorescence imaging, Cancer, 3D modeling, Visualization, Tissues, Neural networks

Proceedings Article | 13 March 2024 Poster

Deep Learning model for efficient instrument response function deconvolution in fluorescence lifetime imaging

Vikas Pandey, Xavier Michalet, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Xavier Intes

Proceedings Volume PC12834, PC128340P (2024) https://doi.org/10.1117/12.3002573

KEYWORDS: Equipment, Deep learning, Instrument modeling, Image deconvolution, Fluorescence lifetime imaging, Mathematical modeling, Imaging systems, Deconvolution, Fluorescence, Dyes

Proceedings Article | 13 March 2024 Presentation

Transformer based deep learning model for fluorescence lifetime parameters estimation using pixelwise instrument response function

Ismail Erbas, Vikas Pandey, Navid Ibtehaj Nizam, Nanxue Yuan, Xavier Intes

Proceedings Volume PC12834, PC128340C (2024) https://doi.org/10.1117/12.3001941

KEYWORDS: Fluorescence, Deep learning, Transformers, Statistical modeling, Instrument modeling, Equipment, Performance modeling, Mathematical modeling, In vivo imaging, Molecular interactions

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Proceedings Article | 13 March 2024 Presentation

Computational fluorescence lifetime imaging

Xavier Intes

Proceedings Volume PC12857, PC1285710 (2024) https://doi.org/10.1117/12.3012723

KEYWORDS: Fluorescence lifetime imaging, 3D image enhancement, 3D image reconstruction, Tissues, Tissue optics, Optical properties, Multiplexing, Image enhancement, Image acquisition, Fluorescence imaging

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Proceedings Article | 13 March 2024 Presentation

3D fluorescence molecular tomography utilizing a novel SPAD camera

Navid Ibtehaj Nizam, Vikas Pandey, Ismail Erbas, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Xavier Michalet, Xavier Intes

Proceedings Volume PC12834, PC1283407 (2024) https://doi.org/10.1117/12.2692977

KEYWORDS: Fluorescence, Cameras, Fluorescence tomography, Stereoscopic cameras, Imaging systems, Structured light, Fluorescence imaging, Tomography, Reflectivity, Near infrared

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Proceedings Article | 13 March 2024 Presentation + Paper

Antibody-target binding quantification in living tumors using macroscopy fluorescence lifetime Forster resonance energy transfer imaging (MFLI FRET)

Nanxue Yuan, Vikas Pandey, Amit Verma, John Williams, Xavier Intes, Margarida Barroso

Proceedings Volume 12821, 1282105 (2024) https://doi.org/10.1117/12.3003282

KEYWORDS: Tumors, Fluorescence resonance energy transfer, Resonance energy transfer, Fluorescence imaging, Fluorescence, Breast, Antibodies, Fluorophores, In vivo imaging, Dyes

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Proceedings Article | 12 March 2024 Presentation + Paper

Organelle-based breast cancer cell classification with deep learning and visual explanations

Harrison Yee, Kailie Matteson, Joshua Goldwag, John Lamar, Margarida Barroso, Xavier Intes, Uwe Kruger

Proceedings Volume 12846, 1284604 (2024) https://doi.org/10.1117/12.3002655

KEYWORDS: Image classification, Breast cancer, Deep learning, Feature extraction, Cancer, Visualization, Confocal microscopy

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SPIE Journal Paper | 5 May 2023 Open Access

Changes in functional neuroimaging measures as novices gain proficiency on the fundamentals of laparoscopic surgery suturing task

Yaoyu Fu, Pushpinder Walia, Steven D. Schwaitzberg, Xavier Intes, Suvranu De, Anirban Dutta, Lora Cavuoto

NPh, Vol. 10, Issue 02, 023521, (May 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.023521

KEYWORDS: Education and training, Machine learning, Neuroimaging, Surgery, Laparoscopy, Statistical analysis, Neurophotonics, Performance modeling, Portability, Eye tracking

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Proceedings Article | 25 April 2023 Paper

Near infrared fluorescence lifetime FRET microscopy to evaluate antibody drug binding in various HER2 positive cancer cell lines

Catherine Sherry, Amit Verma, Jason Smith, Vikas Pandey, Tynan Young, John Williams, Xavier Michalet, Xavier Intes, Margarida Barroso

Proceedings Volume 12384, 123840P (2023) https://doi.org/10.1117/12.2654748

KEYWORDS: Fluorescence resonance energy transfer, Near infrared, Fluorescence, Fluorescence lifetime imaging, In vitro testing, Fluorophores, Dyes, Cancer, Molecules, Microscopy

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SPIE Journal Paper | 10 April 2023 Open Access

Characterization of fluorescence lifetime of organic fluorophores for molecular imaging in the shortwave infrared window

Luis Chavez, Shan Gao, Xavier Intes

JBO, Vol. 28, Issue 09, 094806, (April 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.9.094806

KEYWORDS: Short wave infrared radiation, Fluorophores, Near infrared, Fluorescence, Windows, Multiplexing, Fluorescence intensity, Single photon avalanche diodes, Quantum efficiency, Photons

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Proceedings Article | 27 March 2023 Poster

End-to-end reconstruction for mesoscopic fluorescence molecular tomography via deep learning

Shan Gao, Mengzhou Li, Navid Ibtehaj Nizam, Intes Xavier

Proceedings Volume PC12371, PC123710H (2023) https://doi.org/10.1117/12.2650648

KEYWORDS: Luminescence, Tomography, Fluorescence tomography, Inverse problems, 3D modeling, Spatial resolution, Monte Carlo methods, Biomedical optics, 3D image processing, 3D acquisition

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Proceedings Article | 17 March 2023 Presentation

Monitoring target engagement in vivo via lifetime FRET (Conference Presentation)

Xavier Intes

Proceedings Volume PC12398, PC123980K (2023) https://doi.org/10.1117/12.2655607

KEYWORDS: In vivo imaging, Fluorescence resonance energy transfer, Software development, Therapeutics, Structured light, Molecular imaging, Lead, Drug development, Data processing, Artificial intelligence

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Proceedings Article | 17 March 2023 Presentation

Open access fNIRS dataset of surgical skill execution in the fundamental of laparoscopic program

Anil Kamat, Condell Eastmond, Erim Yanik, Suvranu De, Xavier Intes

Proceedings Volume 12364, 123640E (2023) https://doi.org/10.1117/12.2651202

KEYWORDS: Laparoscopy, Data acquisition, Surgery, Neuroimaging, Brain activation

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Proceedings Article | 17 March 2023 Presentation

Impact of tumor microenvironment in antibody-HER2 binding using macroscopy fluorescence lifetime FRET in vivo imaging

Amit Verma, Vikas Pandey, Jason Smith, Xavier Intes, Margarida Barroso

Proceedings Volume 12357, 123570D (2023) https://doi.org/10.1117/12.2650382

KEYWORDS: Tumors, Fluorescence resonance energy transfer, In vivo imaging, Luminescence, Collagen, Resonance energy transfer, Receptors, Ovarian cancer, Near infrared, Multiplexing

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Proceedings Article | 17 March 2023 Presentation

FRET in small animal optical imaging: Intensity versus lifetime-based approaches

Jason Smith, Nattawut Sinsuebphon, Xavier Michalet, Xavier Intes, Margarida Barroso

Proceedings Volume 12357, 1235707 (2023) https://doi.org/10.1117/12.2650586

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Optical imaging, Imaging systems, Luminescence, Calibration, Receptors

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Proceedings Article | 14 March 2023 Presentation + Paper

Ex vivo mesoscopic assessment of drug delivery and target engagement via lifetime FRET

Shan Gao, Amit Verma, Margarida Barroso, Xavier Intes

Proceedings Volume 12357, 123570F (2023) https://doi.org/10.1117/12.2650632

KEYWORDS: Fluorescence resonance energy transfer, Tumors, Fluorescence, Target acquisition, Tumor growth modeling, Time correlated single photon counting, Ovarian cancer, Molecules, In vivo imaging, Fluorescence tomography

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Proceedings Article | 6 March 2023 Presentation + Paper

Micro-CT guided deep neural network for 3D reconstructions in widefield diffuse optical tomography

Navid Ibtehaj Nizam, Marien Ochoa, Jason Smith, Xavier Intes

Proceedings Volume 12371, 1237105 (2023) https://doi.org/10.1117/12.2650090

KEYWORDS: 3D modeling, Diffuse optical tomography, Neural networks, Light sources and illumination, Inverse problems, Spatial resolution, Optical properties, Optical phantoms

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Proceedings Article | 6 March 2023 Presentation

Multimodal image fusion of time-domain mesoscopic fluorescence molecular tomography and short wave infrared imaging for resolution enhancement

Luis Chavez, Shan Gao, Xavier Intes

Proceedings Volume PC12371, PC123710B (2023) https://doi.org/10.1117/12.2650544

KEYWORDS: Luminescence, Image resolution, Tomography, Resolution enhancement technologies, Infrared imaging, Fluorescence tomography, Short wave infrared radiation, Image fusion, Image enhancement, Scattering

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SPIE Journal Paper | 2 September 2022 Open Access

Special Section Guest Editorial: Computational Approaches for Neuroimaging

Lei Tian, Xavier Intes, Weijian Yang

NPh, Vol. 9, Issue 04, 041401, (September 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.4.041401

KEYWORDS: Neuroimaging, Data processing, Computational imaging, Calcium, Brain, Neuroscience, Optical imaging, Neurophotonics, Near infrared spectroscopy, In vivo imaging

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SPIE Journal Paper | 20 July 2022 Open Access

Deep learning in fNIRS: a review

Condell Eastmond, Aseem Subedi, Suvranu De, Xavier Intes

NPh, Vol. 9, Issue 04, 041411, (July 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.4.041411

KEYWORDS: Brain-machine interfaces, Electroencephalography, Data modeling, Neurophotonics, Feature extraction, Prefrontal cortex, Brain, Machine learning, Deep learning, Education and training

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SPIE Journal Paper | 28 April 2022 Open Access

Monte Carlo-based data generation for efficient deep learning reconstruction of macroscopic diffuse optical tomography and topography applications

Navid Ibtehaj Nizam, Marien Ochoa, Jason T. Smith, Shan Gao, Xavier Intes

JBO, Vol. 27, Issue 08, 083016, (April 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.083016

KEYWORDS: Monte Carlo methods, Data modeling, Luminescence, Computer simulations, Reflectivity, Sensors, In vivo imaging, Absorption, Diffuse optical tomography, 3D modeling

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Significance: Deep learning (DL) models are being increasingly developed to map sensor data to the image domain directly. However, DL methodologies are data-driven and require large and diverse data sets to provide robust and accurate image formation performances. For research modalities such as 2D/3D diffuse optical imaging, the lack of large publicly available data sets and the wide variety of instrumentation designs, data types, and applications leads to unique challenges in obtaining well-controlled data sets for training and validation. Meanwhile, great efforts over the last four decades have focused on developing accurate and computationally efficient light propagation models that are flexible enough to simulate a wide variety of experimental conditions. Aim: Recent developments in Monte Carlo (MC)-based modeling offer the unique advantage of simulating accurately light propagation spatially, temporally, and over an extensive range of optical parameters, including minimally to highly scattering tissue within a computationally efficient platform. Herein, we demonstrate how such MC platforms, namely “Monte Carlo eXtreme” and “Mesh-based Monte Carlo,” can be leveraged to generate large and representative data sets for training the DL model efficiently. Approach: We propose data generator pipeline strategies using these platforms and demonstrate their potential in fluorescence optical topography, fluorescence optical tomography, and single-pixel diffuse optical tomography. These applications represent a large variety in instrumentation design, sample properties, and contrast function. Results: DL models trained using the MC-based in silico datasets, validated further with experimental data not used during training, show accurate and promising results. Conclusion: Overall, these MC-based data generation pipelines are expected to support the development of DL models for rapid, robust, and user-friendly image formation in a wide variety of applications.

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SPIE Journal Paper | 23 April 2022 Open Access

Deep learning-based motion artifact removal in functional near-infrared spectroscopy

Yuanyuan Gao, Hanqing Chao, Lora Cavuoto, Pingkun Yan, Uwe Kruger, Jack Norfleet, Basiel Makled, Steven Schwaitzberg, Suvranu De, Xavier Intes

NPh, Vol. 9, Issue 04, 041406, (April 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.4.041406

KEYWORDS: Data modeling, Motion models, Principal component analysis, Autoregressive models, Wavelets, Near infrared spectroscopy, Performance modeling, Denoising, Computer simulations, Amplifiers

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Proceedings Article | 7 March 2022 Presentation

Antibody-target binding in living tumors using macroscopy fluorescence lifetime imaging

Margarida Barroso, Alena Rudkouskaya, Jason Smith, John Williams, Xavier Intes

Proceedings Volume PC11965, PC119650C (2022) https://doi.org/10.1117/12.2609024

KEYWORDS: Tumors, Fluorescence resonance energy transfer, Near infrared, Fluorescence lifetime imaging, Signal detection, Resonance energy transfer, Microscopy, Imaging systems

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Proceedings Article | 7 March 2022 Presentation

Characterization of a large gated SPAD array for in vivo fluorescence lifetime imaging of drug target engagement

Jason Smith, Alena Rudkouskaya, Shan Gao, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Shimon Weiss, Margarida Barroso, Xavier Intes, Xavier Michalet

Proceedings Volume PC11964, PC1196408 (2022) https://doi.org/10.1117/12.2609888

KEYWORDS: In vivo imaging, Fluorescence lifetime imaging, Sensors, In vitro testing, Visible radiation, Tumors, Near infrared, Luminescence, Fluorescence resonance energy transfer, Detector development

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Proceedings Article | 7 March 2022 Presentation

Multiplexing drug-target engagement and metabolic imaging in HER2-positive tumor xenograft models

Alena Rudkouskaya, Jason Smith, Xavier Intes, Margarida Barroso

Proceedings Volume PC11938, PC1193809 (2022) https://doi.org/10.1117/12.2607308

KEYWORDS: Tumors, Tumor growth modeling, Multiplexing, Fluorescence resonance energy transfer, Systems modeling, Signal detection, Luminescence, Mode conditioning cables, In vivo imaging, Therapeutic antibodies

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Proceedings Article | 4 March 2022 Presentation + Paper

Perception action cycle-related brain networks differentiate experts and novices: a combined EEG, fNIRS study during a complex surgical motor task

Anil Kamat, Jack Norfleet, Xavier Intes, Anirban Dutta, Suvranu De

Proceedings Volume 11945, 1194508 (2022) https://doi.org/10.1117/12.2610063

KEYWORDS: Electroencephalography, Brain, Surgery, Neuroimaging, Prefrontal cortex, Modulation

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Proceedings Article | 4 March 2022 Presentation + Paper

A dilated causal convolutional model for surgical skill assessment using optical neuroimaging

Aseem Subedi, Fnu Rahul, Anirban Dutta, Jack Norfleet, Basiel Makled, Xavier Intes, Suvranu De

Proceedings Volume 11945, 1194509 (2022) https://doi.org/10.1117/12.2610190

KEYWORDS: Neuroimaging, Data modeling, Surgery, Hemodynamics, Data acquisition, Cortical activation, Convolution, Sensors, Neural networks, Laparoscopy

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Proceedings Article | 4 March 2022 Presentation + Paper

NIR fluorescence lifetime macroscopic imaging with a time-gated SPAD camera

X. Michalet, A. Ulku, J. Smith, C. Bruschini, S. Weiss, E. Charbon, X. Intes

Proceedings Volume 11965, 1196507 (2022) https://doi.org/10.1117/12.2607833

KEYWORDS: Signal to noise ratio, Near infrared, Sensors, Fluorescence lifetime imaging, Cameras, Pulsed laser operation, Luminescence, Laser scattering, Data acquisition, Picosecond phenomena

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SPIE Journal Paper | 25 February 2022 Open Access

Deep learning in macroscopic diffuse optical imaging

Jason Smith, Marien Ochoa, Denzel Faulkner, Grant Haskins, Xavier Intes

JBO, Vol. 27, Issue 02, 020901, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.020901

KEYWORDS: Diffuse optical imaging, Luminescence, Data modeling, Neural networks, Tissue optics, Network architectures, Monte Carlo methods, Tissues, Photons, Tumors

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SPIE Journal Paper | 27 July 2021 Open Access

Functional brain connectivity related to surgical skill dexterity in physical and virtual simulation environments (Erratum)

Arun Nemani, Anil Kamat, Yuanyuan Gao, Meryem Yucel, Denise Gee, Clairice Cooper, Steven Schwaitzberg, Xavier Intes, Anirban Dutta, Suvranu De

NPh, Vol. 8, Issue 03, 039801, (July 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.3.039801

KEYWORDS: Virtual reality, Brain, Surgery, Spectroscopy, Neurophotonics, Medicine, Biomedical optics, Neuroimaging

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Proceedings Article | 12 March 2021 Presentation + Paper

Monitoring receptor heterodimerization along intracellular trafficking pathways using anti-HER2 therapeutic antibodies

Alena Rudkouskaya, Jason Smith, Xavier Intes, Margarida Barroso

Proceedings Volume 11624, 116240F (2021) https://doi.org/10.1117/12.2578402

KEYWORDS: Receptors, Therapeutic antibodies, Fluorescence resonance energy transfer, Cancer, Modulation, Luminescence, Switches, Resonance energy transfer, Resistance

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Proceedings Article | 6 March 2021 Presentation

System characterization of time-resolved mesoscopic fluorescence molecular tomography

Shan Gao, Xavier Intes

Proceedings Volume 11634, 116340V (2021) https://doi.org/10.1117/12.2579098

KEYWORDS: Luminescence, Tomography, Fluorescence tomography, Fluorescence resonance energy transfer, Temporal resolution, Fluorescence lifetime imaging, Visualization, Visible radiation, Surgery, Statistical analysis

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Proceedings Article | 5 March 2021 Presentation

Welcome and Introduction to SPIE Conference 11634

Fred Azar, Xavier Intes, Qianqian Fang

Proceedings Volume 11634, 1163402 (2021) https://doi.org/10.1117/12.2593615

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Proceedings Article | 5 March 2021 Presentation

K-space fluorescence tomography in reflectance: a comparison between deep learning and iterative solvers

Navid Ibtehaj Nizam, Marien Ochoa, Jason Smith, Xavier Intes

Proceedings Volume 11634, 116340D (2021) https://doi.org/10.1117/12.2578613

KEYWORDS: Fluorescence tomography, Reflectivity, Diffuse optical tomography, Tumors, Tomography, Resolution enhancement technologies, Reconstruction algorithms, Optical tomography, Monte Carlo methods, Luminescence

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Proceedings Article | 5 March 2021 Presentation

Depth-resolved macroscopic fluorescence lifetime imaging improved though spatial frequency domain imaging

Jason Smith, Enagnon Aguénounon, Sylvain Gioux, Xavier Intes

Proceedings Volume 11625, 116250A (2021) https://doi.org/10.1117/12.2578495

KEYWORDS: Fluorescence lifetime imaging, Monte Carlo methods, Scattering, Process modeling, Near infrared, Luminescence, Absorption, Tissues, Photon transport

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Proceedings Article | 5 March 2021 Presentation

Towards multimodal assessment of surgical skills

Xavier Intes

Proceedings Volume 11634, 116340F (2021) https://doi.org/10.1117/12.2588573

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Proceedings Article | 5 March 2021 Presentation

Towards Fast Quantitative Wide-Field Lifetime Imaging in 2D and 3D

Xavier Intes

Proceedings Volume 11625, 1162508 (2021) https://doi.org/10.1117/12.2593177

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Proceedings Article | 5 March 2021 Presentation

Single-pixel hyperspectral macroscopic autofluorescence lifetime imaging and unmixing with deep learning

Marien Ochoa Mendoza, Jason Smith, Xavier Intes

Proceedings Volume 11655, 1165505 (2021) https://doi.org/10.1117/12.2577898

KEYWORDS: In vivo imaging, Auto-fluorescence imaging, Tissues, In vitro testing, Visible radiation, Structured light, Spectrophotometry, Single photon, Sensors, Near infrared

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SPIE Journal Paper | 3 March 2021 Open Access

Functional brain connectivity related to surgical skill dexterity in physical and virtual simulation environments

Arun Nemani, Anil Kamat, Yuanyuan Gao, Meryem Yucel, Denise Gee, Clairice Cooper, Steven Schwaitzberg, Xavier Intes, Anirban Dutta, Suvranu De

NPh, Vol. 8, Issue 01, 015008, (March 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015008

KEYWORDS: Brain, Shape memory alloys, Surgery, Laparoscopy, Wavelets, Prefrontal cortex, Neurophotonics, Virtual reality, Neurovascular coupling, Sensors

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Significance: Surgical simulators, both virtual and physical, are increasingly used as training tools for teaching and assessing surgical technical skills. However, the metrics used for assessment in these simulation environments are often subjective and inconsistent. Aim: We propose functional activation metrics, derived from brain imaging measurements, to objectively assess the correspondence between brain activation with surgical motor skills for subjects with varying degrees of surgical skill. Approach: Cortical activation based on changes in the oxygenated hemoglobin (HbO) of 36 subjects was measured using functional near-infrared spectroscopy at the prefrontal cortex (PFC), primary motor cortex, and supplementary motor area (SMA) due to their association with motor skill learning. Inter-regional functional connectivity metrics, namely, wavelet coherence (WCO) and wavelet phase coherence were derived from HbO changes to correlate brain activity to surgical motor skill levels objectively. Results: One-way multivariate analysis of variance found a statistically significant difference in the inter-regional WCO metrics for physical simulator based on Wilk’s Λ for expert versus novice, F ( 10,1 ) = 7495.5, p < 0.01. Partial eta squared effect size for the inter-regional WCO metrics was found to be highest between the central prefrontal cortex (CPFC) and SMA, CPFC-SMA (η2 = 0.257). Two-tailed Mann–Whitney U tests with a 95% confidence interval showed baseline equivalence and a statistically significant (p < 0.001) difference in the CPFC-SMA WPCO metrics for the physical simulator training group (0.960 ± 0.045) versus the untrained control group (0.735 ± 0.177) following training for 10 consecutive days in addition to the pretest and posttest days. Conclusion: We show that brain functional connectivity WCO metric corresponds to surgical motor skills in the laparoscopic physical simulators. Functional connectivity between the CPFC and the SMA is lower for subjects that exhibit expert surgical motor skills than untrained subjects in laparoscopic physical simulators.

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Proceedings Article | 27 April 2020 Presentation

Mesoscopic and macroscopic fluorescence lifetime imaging (Conference Presentation)

Xavier Intes

Proceedings Volume 11386, 113860J (2020) https://doi.org/10.1117/12.2558585

KEYWORDS: Fluorescence lifetime imaging, Diffuse optical imaging, Luminescence, Stereoscopy, Tissues, In vivo imaging

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Proceedings Article | 9 March 2020 Presentation

Monitoring receptor-ligand interactions using fluorescence lifetime FRET imaging via deep learning (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Jason Smith, Xavier Intes

Proceedings Volume 11244, 1124419 (2020) https://doi.org/10.1117/12.2546342

KEYWORDS: Luminescence, Fluorescence resonance energy transfer, Near infrared, Visible radiation, Resonance energy transfer, In vitro testing, In vivo imaging, 3D acquisition, 3D image processing, 3D metrology

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Proceedings Article | 19 February 2020 Presentation + Paper

Quantification of anti-HER2 drug uptake into human breast cancer cells using fluorescence lifetime FRET imaging

Alena Rudkouskaya, Jason Smith, Marien Ochoa, Xavier Intes, Margarida Barroso

Proceedings Volume 11219, 112190C (2020) https://doi.org/10.1117/12.2544429

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Breast cancer, Fluorescence lifetime imaging, Confocal microscopy, Cancer, Near infrared, Microscopy, Plasma, Tumors

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Proceedings Article | 7 March 2019 Presentation + Paper

Handling negative patterns for fast single-pixel lifetime imaging

Antonio Lorente Mur, Marien Ochoa, Jérémy Cohen, Xavier Intes, Nicolas Ducros

Proceedings Volume 10862, 108620A (2019) https://doi.org/10.1117/12.2511123

KEYWORDS: Spatial light modulators, Matrices, Image compression, Wavelets, Cameras, Sensors, Reconstruction algorithms, Time metrology, Hyperspectral imaging

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Proceedings Article | 7 March 2019 Presentation

Accelerating Monte Carlo forward model with structured light illumination via “photon sharing” (Conference Presentation)

Ruoyang Yao, Shijie Yan, Xavier Intes, Qianqian Fang

Proceedings Volume 10874, 108740B (2019) https://doi.org/10.1117/12.2510291

KEYWORDS: Monte Carlo methods, Structured light, Photon transport, Computer simulations, Diffuse optical tomography, Signal to noise ratio, Optical tomography, Tomography, Data acquisition, Whole body imaging

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Proceedings Article | 4 March 2019 Presentation

MFLI-FRET as an analytical tool to monitor drug distribution and penetration in tumor xenografts, liver and bladder in intact, live animals (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes

Proceedings Volume 10859, 108590D (2019) https://doi.org/10.1117/12.2507523

KEYWORDS: Tumors, Liver, Bladder, Breast cancer, Fluorescence resonance energy transfer, Receptors, Near infrared, Microfluidic imaging, Microfluidics, Blood circulation

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Proceedings Article | 4 March 2019 Presentation

Deep learning for quantitative bi-exponential fluorescence lifetime imaging (Conference Presentation)

Jason Smith, Ruoyang Yao, Sez-Jade Chen, Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Pingkun Yan, Xavier Intes

Proceedings Volume 10871, 108710J (2019) https://doi.org/10.1117/12.2509857

KEYWORDS: Fluorescence lifetime imaging, Biomedical optics, Super resolution, Microscopy, Whole body imaging, Resonance energy transfer, Fluorescence resonance energy transfer, Neural networks, Luminescence

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Proceedings Article | 4 March 2019 Presentation

Fusion of optical coherence tomography and mesoscopic fluorescence molecular tomography via Laplacian spatial priors (Conference Presentation)

Denzel Faulkner, Ruoyang Yao, David Kingsley, David Corr, Xavier Intes

Proceedings Volume 10871, 108710C (2019) https://doi.org/10.1117/12.2508819

KEYWORDS: Optical coherence tomography, Luminescence, Fluorescence tomography, Tomography, Molecular imaging, Tissues, Inverse optics, Inverse problems, Optical tomography, Preclinical imaging

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Proceedings Article | 4 March 2019 Presentation

IRDye QC-1 as a near-infrared dark acceptor for fluorescence lifetime FRET measurements in cells and in live intact animals (Conference Presentation)

Sez-Jade Chen, Alena Rudkouskaya, Joseph Mazurkiewicz, Marien Ochoa Mendoza, Nattawut Sinsuebphon, Margarida Barroso, Xavier Intes

Proceedings Volume 10882, 108820N (2019) https://doi.org/10.1117/12.2508056

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Near infrared, In vivo imaging, Multiplexing, Confocal microscopy, Fluorescence lifetime imaging, Resonance energy transfer, Organisms, Absorbance

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Proceedings Article | 1 March 2019 Presentation + Paper

Dynamic macroscopic in vivo FRET for the quantitative monitoring of targeted receptor engagement

Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes

Proceedings Volume 10877, 108770F (2019) https://doi.org/10.1117/12.2510695

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, In vivo imaging, Receptors, Physiology, Imaging systems, Picosecond phenomena, Molecular imaging

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SPIE Journal Paper | 14 September 2018 Open Access

Review of structured light in diffuse optical imaging

Joseph Angelo, Sez-Jade Chen, Marien Ochoa, Ulas Sunar, Sylvain Gioux, Xavier Intes

JBO, Vol. 24, Issue 07, 071602, (September 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.7.071602

KEYWORDS: Imaging systems, Tomography, Structured light, Diffuse optical imaging, Sensors, Tissue optics, Luminescence, Scattering, Spatial frequencies, Photons

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Proceedings Article | 14 March 2018 Presentation

Fast in vivo quantification of receptor engagement by phasor analysis of NIR fluorescence lifetime (Conference Presentation)

Sez-Jade Chen, Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes, Xavier Michalet

Proceedings Volume 10487, 104870I (2018) https://doi.org/10.1117/12.2289084

KEYWORDS: In vivo imaging, Near infrared, Luminescence, Fluorescence resonance energy transfer, Absorption, Receptors, Preclinical imaging, Fluorescent markers, Molecular imaging, Image-guided intervention

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Proceedings Article | 14 March 2018 Presentation

Deep tissue imaging of target engagement in live animals (Conference Presentation)

Margarida Barroso, Xavier Intes, Nattawut Sinsuebphon, Alena Rudkouskaya

Proceedings Volume 10475, 104750A (2018) https://doi.org/10.1117/12.2290807

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Receptors, Cancer, Optical imaging, Tumors, Imaging systems, Deep tissue imaging, Luminescence, Oncology

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Proceedings Article | 14 March 2018 Presentation

Near infrared fluorescence lifetime FRET imaging of target engagement at multiscale (Conference Presentation)

Margarida Barroso, Alena Rudkouskaya, Jamie Ward, Joseph Mazurkiewicz, Nattawut Sinsuebphon, Sez-Jade Chen, Xavier Intes

Proceedings Volume 10498, 104980R (2018) https://doi.org/10.1117/12.2297567

KEYWORDS: Near infrared, Luminescence, Fluorescence resonance energy transfer, Receptors, Microscopy, In vivo imaging, Cancer, In vitro testing, Proteins, Therapeutic antibodies

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Proceedings Article | 14 March 2018 Presentation

Novel platform for optically guided head and neck robotic surgery (Conference Presentation)

Brett Miles, Xavier Intes, Sylvain Gioux

Proceedings Volume 10469, 1046918 (2018) https://doi.org/10.1117/12.2297463

KEYWORDS: Head, Neck, Robotic surgery, Tissue optics, Tissues, Tumors, Robotics, Cancer, Real time imaging, Endoscopy

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SPIE Journal Paper | 20 September 2017 Open Access

Optical tomographic imaging for breast cancer detection

Wenxiang Cong, Xavier Intes, Ge Wang

JBO, Vol. 22, Issue 09, 096011, (September 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.9.096011

KEYWORDS: Tumors, Tissues, Absorption, Breast, Image restoration, Breast cancer, Mammography, Optical imaging, Tomography, Tissue optics

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Proceedings Article | 24 August 2017 Paper

Compressive hyperspectral time-resolved wide-field fluorescence lifetime imaging

Xavier Intes

Proceedings Volume 10394, 1039404 (2017) https://doi.org/10.1117/12.2273926

KEYWORDS: Data acquisition, Luminescence, In vivo imaging, Fluorescence lifetime imaging, Biomedical optics, Imaging systems, Fluorescence resonance energy transfer, Digital micromirror devices, Hyperspectral imaging, Monte Carlo methods, Optical tomography

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SPIE Journal Paper | 2 June 2017 Open Access

Dental optical tomography with upconversion nanoparticles—a feasibility study

Feixiao Long, Xavier Intes

JBO, Vol. 22, Issue 06, 066001, (June 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.6.066001

KEYWORDS: Upconversion, Nanoparticles, Optical tomography, Near infrared, Tomography, Visible radiation

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Proceedings Article | 19 April 2017 Presentation

Fluorescence lifetime FRET non-invasive imaging of breast cancer xenografts provides a measure of target engagement in vivo (Conference Presentation)

Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes, Margarida Barroso

Proceedings Volume 10049, 1004908 (2017) https://doi.org/10.1117/12.2257114

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Fluorescence lifetime imaging, Breast cancer, Receptors, Cancer, Luminescence, Near infrared, Mammography, Tumors

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Proceedings Article | 21 February 2017 Presentation + Paper

Fluorescence lifetime FRET imaging of receptor-ligand complexes in tumor cells in vitro and in vivo

Alena Rudkouskaya, Nattawut Sinsuebphon, Xavier Intes, Joseph Mazurkiewicz, Margarida Barroso

Proceedings Volume 10069, 1006917 (2017) https://doi.org/10.1117/12.2258231

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Fluorescence lifetime imaging, Therapeutics, Receptors, Optical imaging, Resonance energy transfer, Oncology, Near infrared, Microscopy, Tumors, Cancer

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Proceedings Article | 21 October 2016 Paper

Innovation and fusion of x-ray and optical tomography for mouse studies of breast cancer

Ge Wang, Wenxiang Cong, Qingsong Yang, Qi Pian, Shouping Zhu, Jimin Liang, Margarida Barroso, Xavier Intes

Proceedings Volume 9967, 99671R (2016) https://doi.org/10.1117/12.2238188

KEYWORDS: X-rays, Imaging systems, X-ray optics, Optical tomography, Breast cancer, X-ray imaging, Tomography, Tissue optics, Receptors, Tumors

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Proceedings Article | 10 March 2016 Paper

Gate-width impact on NIR FRET lifetime fitting using gated ICCD

Sez-Jade Chen, Xavier Intes

Proceedings Volume 9701, 970117 (2016) https://doi.org/10.1117/12.2217780

KEYWORDS: Fluorescence resonance energy transfer, Near infrared, In vivo imaging, Resonance energy transfer, In vitro testing, Visualization, Fluorescence lifetime imaging, Molecular interactions, Absorption, Light scattering, Photons, Picosecond phenomena, Tumors, Liver, Tissues, Charge-coupled devices

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Proceedings Article | 10 March 2016 Paper

Time-resolved hyperspectral single-pixel camera implementation for compressive wide-field fluorescence lifetime imaging

Qi Pian, Ruoyang Yao, Xavier Intes

Proceedings Volume 9701, 970115 (2016) https://doi.org/10.1117/12.2217686

KEYWORDS: Data acquisition, Digital micromirror devices, Cameras, Signal to noise ratio, Image quality, Liver, Image restoration, Modulation, Luminescence, Fluorescence lifetime imaging

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Proceedings Article | 10 March 2016 Paper

Sparse temporal sampling for fast time-domain wide-field fluorescence molecular tomography

Ruoyang Yao, Lingling Zhao, Xavier Intes

Proceedings Volume 9701, 970116 (2016) https://doi.org/10.1117/12.2217760

KEYWORDS: Neon, Kidney, Luminescence, Tomography, Fluorescence tomography, Sensors, Optical tomography, Monte Carlo methods, Signal to noise ratio, Multiplexing

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SPIE Journal Paper | 8 March 2016 Open Access

Radiative transfer equation modeling by streamline diffusion modified continuous Galerkin method

Feixiao Long, Fengyan Li, Xavier Intes, Shiva Kotha

JBO, Vol. 21, Issue 03, 036003, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.3.036003

KEYWORDS: Diffusion, Optical properties, Computer simulations, Radiative transfer, Optical simulations, Scattering, 3D modeling, Chemical elements, Monte Carlo methods, Finite element methods

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Proceedings Article | 29 February 2016 Paper

Wide-field lifetime-based FRET imaging for the assessment of early functional distribution of transferrin-based delivery in breast tumor-bearing small animals

Nattawut Sinsuebphon, Alena Rudkouskaya, Margarida Barroso, Xavier Intes

Proceedings Volume 9689, 968945 (2016) https://doi.org/10.1117/12.2217845

KEYWORDS: Fluorescence resonance energy transfer, Breast cancer, Cancer, Resonance energy transfer, Tumors, Data acquisition, Receptors

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SPIE Journal Paper | 28 August 2014 Open Access

Reduced temporal sampling effect on accuracy of time-domain fluorescence lifetime Förster resonance energy transfer

Travis Omer, Lingling Zhao, Xavier Intes, Juergen Hahn

JBO, Vol. 19, Issue 08, 086023, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086023

KEYWORDS: Luminescence, Fluorescence resonance energy transfer, In vivo imaging, Data modeling, Picosecond phenomena, In vitro testing, Error analysis, Resonance energy transfer, Imaging systems, Fluorescence lifetime imaging

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Proceedings Article | 17 February 2014 Paper

Dental imaging using laminar optical tomography and micro CT

Feixiao Long, Mehmet Ozturk, Xavier Intes, Shiva Kotha

Proceedings Volume 8937, 89370P (2014) https://doi.org/10.1117/12.2037766

KEYWORDS: Teeth, Luminescence, Optical tomography, Tissues, Optical imaging, X-ray computed tomography, Sensors, Image resolution, Computed tomography, Capillaries

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Proceedings Article | 17 February 2014 Paper

High resolution 3D image reconstruction in laminar optical tomography based on compressive sensing

Fugang Yang, Mehmet Ozturk, Wenxiang Cong, Ge Wang, Xavier Intes

Proceedings Volume 8937, 89370R (2014) https://doi.org/10.1117/12.2037890

KEYWORDS: Inverse problems, Optical tomography, Compressed sensing, Data modeling, Image resolution, Image restoration, Luminescence, Monte Carlo methods, Sensors, 3D image reconstruction

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Proceedings Article | 17 February 2014 Paper

Mesh optimization for fluorescence molecular tomography

Andrew Edmans, Cameron Smith, Xavier Intes

Proceedings Volume 8937, 89370S (2014) https://doi.org/10.1117/12.2038140

KEYWORDS: Luminescence, Monte Carlo methods, 3D modeling, Data modeling, Fluorescence tomography, Tomography, Optimization (mathematics), Optical tomography, Photons, Performance modeling

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Proceedings Article | 17 February 2014 Paper

Comparison of lp-regularization-based reconstruction methods for time domain fluorescence molecular tomography on early time gates

Lingling Zhao, He Yang, Wenxiang Cong, Ge Wang, Xavier Intes

Proceedings Volume 8937, 89370V (2014) https://doi.org/10.1117/12.2038662

KEYWORDS: Luminescence, Tomography, Monte Carlo methods, Spatial resolution, Reconstruction algorithms, Fluorescence tomography, Inverse problems, Kidney, 3D modeling, Data modeling

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Proceedings Article | 17 February 2014 Paper

Comparison of NIR FRET pairs for quantitative transferrin-based assay

Nattawut Sinsuebphon, Travis Bevington, Lingling Zhao, Abe Ken, Margarida Barroso, Xavier Intes

Proceedings Volume 8937, 89370X (2014) https://doi.org/10.1117/12.2040097

KEYWORDS: Fluorescence resonance energy transfer, Near infrared, In vivo imaging, Luminescence, Picosecond phenomena, Cancer, Quantum efficiency, In vitro testing, Photons, Iron

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Proceedings Article | 17 February 2014 Paper

Structured light based hyperspectral time-resolved diffuse optical tomography system

Qi Pian, Xavier Intes

Proceedings Volume 8937, 89370T (2014) https://doi.org/10.1117/12.2038546

KEYWORDS: Data acquisition, Absorption, Digital Light Processing, Imaging systems, Monte Carlo methods, Diffuse optical tomography, Luminescence, Scattering, Digital micromirror devices, Structured light

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SPIE Journal Paper | 3 October 2013 Open Access

Mesoscopic fluorescence molecular tomography of reporter genes in bioprinted thick tissue

Mehmet Ozturk, Vivian Lee, Lingling Zhao, Guohoa Dai, Xavier Intes

JBO, Vol. 18, Issue 10, 100501, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.100501

KEYWORDS: Tissues, Green fluorescent protein, Luminescence, Tomography, Microscopy, Fluorescence tomography, Tissue engineering, Tissue optics, Optical coherence tomography, 3D image processing

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Proceedings Article | 18 June 2013 Paper

Active illumination for wide-field time-resolved fluorescence imaging

Lingling Zhao, Ken Abe, Margarida Barroso, Xavier Intes

Proceedings Volume 8801, 88010D (2013) https://doi.org/10.1117/12.2033425

KEYWORDS: Luminescence, Photon counting, Signal to noise ratio, Signal detection, Time resolved spectroscopy, Fluorescence lifetime imaging, Sensors, Optimization (mathematics), Fluorescence resonance energy transfer, Ranging

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Proceedings Article | 18 June 2013 Paper

Near infrared FRET using wide-field fluorescence lifetime imaging in live animals

Lingling Zhao, Ken Abe, Margarida Barroso, Xavier Intes

Proceedings Volume 8801, 88010A (2013) https://doi.org/10.1117/12.2033588

KEYWORDS: Fluorescence resonance energy transfer, Near infrared, Fluorescence lifetime imaging, Tumors, In vivo imaging, In vitro testing, Luminescence, Imaging systems, Cancer, Target detection

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Proceedings Article | 14 June 2013 Paper

Mesoscopic tomography imaging of reporter genes in thick printed tissue constructs

Mehmet Ozturk, Vivian Lee, Lingling Zhao, Guohoa Dai, Xavier Intes

Proceedings Volume 8799, 87990Y (2013) https://doi.org/10.1117/12.2032539

KEYWORDS: Tissues, Green fluorescent protein, Tomography, Luminescence, 3D image processing, Ocean optics, 3D image reconstruction, Tissue engineering, Fluorescence tomography, 3D modeling

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Proceedings Article | 25 March 2013 Paper

Robust imaging strategies in time-resolved optical tomography

Vivek Venugopal, Jin Chen, Xavier Intes

Proceedings Volume 8578, 857827 (2013) https://doi.org/10.1117/12.2005084

KEYWORDS: Luminescence, Optical tomography, Signal to noise ratio, Electronic filtering, Error analysis, Tomography, Sensors, Photon counting, RGB color model, Time correlated photon counting

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SPIE Journal Paper | 8 March 2013 Open Access

Adaptive wide-field optical tomography

Vivek Venugopal, Xavier Intes

JBO, Vol. 18, Issue 03, 036006, (March 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.036006

KEYWORDS: Photons, Luminescence, Tomography, Animal model studies, Optical tomography, Optimization (mathematics), Signal detection, Sensors, Transmittance, Quantum efficiency

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SPIE Journal Paper | 1 October 2012 Open Access

Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography

Jin Chen, Qianqian Fang, Xavier Intes

JBO, Vol. 17, Issue 10, 106009, (October 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.106009

KEYWORDS: Monte Carlo methods, Luminescence, Tomography, Sensors, Computer simulations, Photon transport, Picosecond phenomena, Fluorescence tomography, Data modeling, In vivo imaging

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Proceedings Article | 10 February 2011 Paper

In vivo reconstruction of NIR FRET using full-field time resolved optical tomography

Vivek Venugopal, Jin Chen, Margarida Barroso, Xavier Intes

Proceedings Volume 7892, 78920I (2011) https://doi.org/10.1117/12.881798

KEYWORDS: Fluorescence resonance energy transfer, Molecules, Animal model studies, Near infrared, 3D modeling, Magnetic resonance imaging, Data modeling, Quantum efficiency, Optical tomography, Luminescence

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SPIE Journal Paper | 1 January 2010 Open Access

Real-time diffuse optical tomography based on structured illumination

Samuel Bélanger, Maxime Abran, Xavier Intes, Christian Casanova, Frederic Lesage

JBO, Vol. 15, Issue 01, 016006, (January 2010) https://doi.org/10.1117/12.10.1117/1.3290818

KEYWORDS: Digital micromirror devices, Diffuse optical tomography, Sensors, Diffusion, Computer simulations, Tomography, Cameras, Imaging systems, Monte Carlo methods, Mirrors

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Proceedings Article | 20 February 2009 Paper

Diffuse optical tomography with time-gated perturbation Monte Carlo method

Jin Chen, Vivek Venugopal, Xavier Intes

Proceedings Volume 7171, 717113 (2009) https://doi.org/10.1117/12.822556

KEYWORDS: Photons, Monte Carlo methods, Scattering, Diffusion, Absorption, Tissue optics, Optical properties, Sensors, 3D modeling, Inverse optics

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Proceedings Article | 20 February 2009 Paper

Quantifying optical properties in small animals using MR-guided multispectral time-resolved imaging

Vivek Venugopal, Jin Chen, Xavier Intes

Proceedings Volume 7171, 717114 (2009) https://doi.org/10.1117/12.822557

KEYWORDS: Optical properties, Error analysis, Magnetic resonance imaging, Multispectral imaging, Imaging systems, Picosecond phenomena, Tissues, Sensors, Absorption, Tissue optics

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Proceedings Article | 20 February 2009 Paper

Unmixing multiple markers with spectral lifetime measurements

Krenar Tasimi, Xavier Intes, Badrinath Roysam

Proceedings Volume 7171, 717112 (2009) https://doi.org/10.1117/12.822555

KEYWORDS: Dysprosium, Image segmentation, Luminescence, Computer simulations, Multispectral imaging, Tissues, Diagnostics, Breast, Data modeling, Systems modeling

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Proceedings Article | 13 February 2007 Paper

Pharmacokinetic assessment of a polymersome-based molecular beacon by in vivo fluorescence monitoring

Ulas Sunar, P. Peter Ghoroghchian, Xavier Intes, Michael Therien, Daniel Hammer, Arjun Yodh

Proceedings Volume 6434, 64342I (2007) https://doi.org/10.1117/12.700802

KEYWORDS: Tumors, Luminescence, Polymers, Optical filters, Tissues, In vivo imaging, Sensors, Semiconductor lasers, Liver, Blood

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Proceedings Article | 22 February 2006 Paper

Spatially resolved pharmacokinetic rate images of ICG using near-infrared optical methods

Burak Alacam, Birsen Yazici, Xavier Intes, Shoko Nioka, Britton Chance

Proceedings Volume 6088, 60881N (2006) https://doi.org/10.1117/12.647205

KEYWORDS: Tumors, Plasma, Absorption, Near infrared, Capillaries, Breast cancer, Breast, Tissues, Sensors, Filtering (signal processing)

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Proceedings Article | 13 February 2006 Paper

Fast CW imager for ICG and Gd kinetics

David Busch, Zhongyao Zhao, Shoko Nioka, Arjun Yodh, Mitchell Schnall, Britton Chance, Xavier Intes

Proceedings Volume 6081, 60810R (2006) https://doi.org/10.1117/12.649400

KEYWORDS: Gadolinium, Sensors, Breast, Optical fibers, Magnetic resonance imaging, Radio optics, Absorption, Tissues, Imaging systems

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Proceedings Article | 28 April 2005 Paper

Extended Kalman filtering for the modeling and analysis of ICG pharmacokinetics using NIR optical methods

Burak Alacam, Birsen Yazici, Xavier Intes, Britton Chance

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.589751

KEYWORDS: Tumors, Filtering (signal processing), Near infrared, Plasma, Tissues, Systems modeling, Capillaries, Electronic filtering, Tumor growth modeling, Error analysis

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Proceedings Article | 9 December 2004 Paper

Time-domain optical mammography Softscan: initial results on detection and characterization of breast tumors

Xavier Intes, Salim Djeziri, Zahia Ichalalene, Niculae Mincu, Yong Wang, Philippe St.-Jean, Frédéric Lesage, David Hall, David Boas, Margaret Polyzos

Proceedings Volume 5578, (2004) https://doi.org/10.1117/12.593755

KEYWORDS: Breast, Tissues, Tissue optics, Absorption, Mammography, Scattering, Optical properties, Blood, Tumors, Optical fibers

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Proceedings Article | 9 December 2004 Paper

Time domain fluorescent diffuse optical tomography

Sirithy Lam, Frederic Lesage, Xavier Intes

Proceedings Volume 5578, (2004) https://doi.org/10.1117/12.593754

KEYWORDS: Neodymium, Tissue optics, Near infrared, Diffuse optical tomography, Inverse problems, Photons, 3D modeling, Luminescence, Molecules, Sensors

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Proceedings Article | 20 August 2004 Paper

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

Yu Chen, Gang Zheng, Zhihong Zhang, Dana Blessington, Xavier Intes, Samuel Achilefu, Britton Chance

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578379

KEYWORDS: Tumors, Luminescence, Imaging systems, Tissues, Photons, Breast, In vivo imaging, Phased arrays, Signal detection, Near infrared

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Proceedings Article | 8 December 2003 Paper

Assessment of tumor angiogenesis using fluorescence contrast agents

Yu Chen, Qian Liu, Ping Huang, Shay Hyman, Xavier Intes, William Lee, Britton Chance

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546210

KEYWORDS: Tumors, Tissues, Luminescence, Indocyanine green, Data modeling, Animal model studies, Interference filters, Blood, Tissue optics, Optical imaging

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Proceedings Article | 15 October 2003 Paper

Three-dimensional diffuse optical tomography with a priori anatomical information

Murat Guven, Birsen Yazici, Xavier Intes, Britton Chance

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.500834

KEYWORDS: Inverse problems, 3D image processing, Absorption, Image analysis, Image restoration, Spatial resolution, Reconstruction algorithms, Diffuse optical tomography, Inverse optics, 3D modeling

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Proceedings Article | 12 September 2003 Paper

Simulation of delivery of indocynanine green injected intravenously into the human subject for breast cancer detection

Ping Huang, Xavier Intes, Britton Chance, Shoko Nioka

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476527

KEYWORDS: Tumors, Breast cancer, Tumor growth modeling, Human subjects, Cancer, Tissues, Data modeling, Luminescence, Capillaries, Ordinary differential equations

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Proceedings Article | 29 July 2003 Paper

Determination of subsurface tumor localization in animal models with near-infrared (NIR) fluorescence imaging

Yu Chen, Dana Blessington, Zhihong Zhang, Qian Liu, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel Achilefu, Hui Li, Min Zhang, Gang Zheng, Britton Chance

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478187

KEYWORDS: Tumors, Luminescence, Animal model studies, Scattering, Near infrared, Phased arrays, In vivo imaging, Breast, Signal detection, Imaging systems

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Proceedings Article | 29 July 2003 Paper

Application of I&Q detection system in scouting the curative effect of neck squamous cell carcinoma

Jun Zhang, Tao Tu, Ulas Sunar, Xavier Intes, Shoko Nioka, Zhihong Zhang, Alex Kilger, Robert Lustig, Laurie Loevner, Britton Chance

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478177

KEYWORDS: Neck, Tissue optics, Cancer, Blood, Tumors, Near infrared spectroscopy, Radiotherapy, Imaging spectroscopy, Absorption, Skin

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Proceedings Article | 29 July 2003 Paper

Diffuse optical tomography with a priori anatomical information

Murat Guven, Birsen Yazici, Xavier Intes, Britton Chance

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.479799

KEYWORDS: Absorption, Tissue optics, Spatial resolution, Inverse problems, Signal to noise ratio, Magnetic resonance imaging, Diffuse optical tomography, Diffusion, Image restoration, Optical imaging

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SPIE Journal Paper | 1 October 2002 Open Access

Analysis on performance and optimization of frequency-domain near-infrared instruments

Tao Tu, Yu Chen, Zhang Jun, Xavier Intes, Britton Chance

JBO, Vol. 7, Issue 04, (October 2002) https://doi.org/10.1117/12.10.1117/1.1501562

KEYWORDS: Signal to noise ratio, Instrument modeling, Signal detection, Modulation, Signal attenuation, Interference (communication), Diffusion, Sensors, Performance modeling, Light

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Proceedings Article | 12 September 2002 Paper

Phase cancellation system for tumor imaging using targeted fluorescent contrast agents

Yu Chen, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel Achilefu, Britton Chance

Proceedings Volume 4916, (2002) https://doi.org/10.1117/12.482934

KEYWORDS: Tumors, Imaging systems, Phased arrays, Luminescence, Tissues, Signal detection, Phase only filters, Modulation, Phase measurement, Scattering

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Proceedings Article | 12 April 2002 Paper

Combining various projection access schemes with the algebraic reconstruction technique for diffuse optical tomography

Xavier Intes, Vasilis Ntziachristos, Arjun Yodh, Britton Chance

Proceedings Volume 4536, (2002) https://doi.org/10.1117/12.462533

KEYWORDS: Reconstruction algorithms, Absorption, Tissues, Diffuse optical tomography, Image quality, Diffusion, Sensors, Inverse problems, Image restoration, Chromophores

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Proceedings Article | 12 April 2002 Paper

Method and application for imaging breast cancer using a contrast agent

Ping Huang, Xavier Intes, Shoko Nioka, Toshiyuki Kitai, Britton Chance

Proceedings Volume 4536, (2002) https://doi.org/10.1117/12.462549

KEYWORDS: Absorption, Breast cancer, Reconstruction algorithms, Tissues, Sensors, Breast, Near infrared, Diffusion, Photons, Cancer

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Proceedings Article | 12 April 2002 Paper

Diffuse optical tomography using dual-interfering source

Yu Chen, Chenpeng Mu, Xavier Intes, Britton Chance

Proceedings Volume 4536, (2002) https://doi.org/10.1117/12.462559

KEYWORDS: Sensors, Phased arrays, Absorption, Modulation, Imaging systems, Image restoration, Diffuse optical tomography, Tomography, Scattering, Signal detection

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Proceedings Article | 29 June 2001 Paper

Imaging with dual-interfering sources

Xavier Intes, Vasilis Ntziachristos, Arjun Yodh, Britton Chance

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434471

KEYWORDS: Phased arrays, Sensors, Diffusion, Inverse problems, Absorption, Scattering media, Tissue optics, Scattering, Mathematical modeling, Data modeling

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Proceedings Article | 29 June 2001 Paper

Detection sensitivity and optimization of a phased-array system

Yu Chen, Xavier Intes, Shuoming Zhou, Chenpeng Mu, Monica Holboke, Arjun Yodh, Britton Chance

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434492

KEYWORDS: Absorption, Phased arrays, Scattering, Signal detection, Signal to noise ratio, Phase shift keying, Interference (communication), Diffusion, Modulation, Tissue optics

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Proceedings Article | 22 November 2000 Paper

Dual interfering sources with a fluorescent object

Xavier Intes, K. Kang, Monica Holboke, Arjun Yodh, Britton Chance

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407628

KEYWORDS: Sensors, Breast, Phased arrays, Diffusion, Signal detection, Optical properties, Scattering media, Finite difference methods, Light wave propagation, Tissues

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Proceedings Article | 15 July 1999 Paper

Localization of the virtual point source used in the diffusion approximation to model collimated beam source

Xavier Intes, Bernard Le Jeune, Fabrice Pellen, Yves Guern, Jack Cariou, Jean Lotrian

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356796

KEYWORDS: Collimation, Scattering, Diffusion, Protactinium, Virtual point source, Modulation, Laser scattering, Signal detection, Modeling, Reflectivity

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SPIE Conference Volume | 3 April 2024

Multimodal Biomedical Imaging XIX

SPIE Conference Volume | 30 March 2023

Multimodal Biomedical Imaging XVIII

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Multimodal Biomedical Imaging XVII

SPIE Conference Volume | 1 April 2021

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SPIE Conference Volume | 6 March 2020

Multimodal Biomedical Imaging XV

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Multimodal Biomedical Imaging XIX

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Multimodal Biomedical Imaging XVIII

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